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4990367 Canine distemper virus vaccine
New Patents Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials, substrates, and the like, wherein the immunostimulant properties of lipid A are desired.
4988630 MULTIPLE BEAM LASER INSTRUMENT FOR MEASURING AGGLUTINATION REACTIONS
4990367 CANINE DISTEMPER VACCINE
VIRUS
Edmund P Bass, William H Kelsey, Michael D McFarland assigned to Diamond Scientific Company A vaccine composition for animals susceptible to infection by canine distemper virus. The vaccine comprises a small but immunologically effective amount of an inactivated canine distemper virus in combination with a non-toxic pharmaceutically acceptable immunologic adjuvant. A preferred method of inactivation of canine distemper virus by either exposure of the virus to an inactivating effective amount of binary ethyleneimine or alternatively exposure of the virus to long wavelength ultraviolet light in the presence of a furocoumarin.
4990536 Fang-Chung Chen, Michael L Franklin assigned to Hoffmann-La Roche Inc There is described a unique instrument system employing a laser, having a polarized and collimated beam of radiation, which is split into a multitude of primary and secondary beams containing the same desirable properties of high collimation and monochromaticity. The secondary beams are used to measure simultaneously multiple antigen-antibody (Ag-Ab) agglutinations reactions involving latex particles.
4988676 CELLULAR PROLIFERATION T CELL SUPPRESSOR FACTOR Chris Platsoucas assigned to Sloan-Kettering Institute for Cancer Research New human T cell suppressor factors have been identified which suppress mitogen, antigen or alloantigen driven cellular proliferation of human peripheral blood leukocytes, as well as antibody synthesis and secretion and growth of human tumor cell lines. Such factors have potential use for the treatment of graft versus host disease, autoimmune disease and lympho-proliferative disorders such as leukemia as well as other malignancies.
IMMUNOPOTENTIATOR AND SPERGUALIN-RELATED COMPOUND THEREFOR Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda, Urawa, Japan assigned to Nippon Kayaku Kabushiki Kaisha; Takara Shuzo Co Ltd The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: See Patentfor Chemical Structure (I) wherein X represents See Patent for Chemical Structure or -(CH2)n-, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group, n is an integer of 3 or 5, and R represents -(CH2)4-RI (wherein RI is NH2 or -OH), -(CH2)3-R2 (wherein R2 is COOH or -CHO), -(CH2)4-NH-(CH2)3-OH or -(CH2)4-NH-(CH2)2-R2 (wherein R2 is as defined above).
4990596 SYNTHETIC PEPTIDE PRODUCING ANTIBODIES OF ENHANCED BINDING TO HUMAN LDH-C4 Erwin Goldberg assigned to Northwestern University
4988630 MULTIPLE BEAM LASER INSTRUMENT FOR MEASURING AGGLUTINATION REACTIONS
4990367 CANINE DISTEMPER VACCINE
VIRUS
Edmund P Bass, William H Kelsey, Michael D McFarland assigned to Diamond Scientific Company A vaccine composition for animals susceptible to infection by canine distemper virus. The vaccine comprises a small but immunologically effective amount of an inactivated canine distemper virus in combination with a non-toxic pharmaceutically acceptable immunologic adjuvant. A preferred method of inactivation of canine distemper virus by either exposure of the virus to an inactivating effective amount of binary ethyleneimine or alternatively exposure of the virus to long wavelength ultraviolet light in the presence of a furocoumarin.
4990536 Fang-Chung Chen, Michael L Franklin assigned to Hoffmann-La Roche Inc There is described a unique instrument system employing a laser, having a polarized and collimated beam of radiation, which is split into a multitude of primary and secondary beams containing the same desirable properties of high collimation and monochromaticity. The secondary beams are used to measure simultaneously multiple antigen-antibody (Ag-Ab) agglutinations reactions involving latex particles.
4988676 CELLULAR PROLIFERATION T CELL SUPPRESSOR FACTOR Chris Platsoucas assigned to Sloan-Kettering Institute for Cancer Research New human T cell suppressor factors have been identified which suppress mitogen, antigen or alloantigen driven cellular proliferation of human peripheral blood leukocytes, as well as antibody synthesis and secretion and growth of human tumor cell lines. Such factors have potential use for the treatment of graft versus host disease, autoimmune disease and lympho-proliferative disorders such as leukemia as well as other malignancies.
IMMUNOPOTENTIATOR AND SPERGUALIN-RELATED COMPOUND THEREFOR Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda, Urawa, Japan assigned to Nippon Kayaku Kabushiki Kaisha; Takara Shuzo Co Ltd The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: See Patentfor Chemical Structure (I) wherein X represents See Patent for Chemical Structure or -(CH2)n-, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group, n is an integer of 3 or 5, and R represents -(CH2)4-RI (wherein RI is NH2 or -OH), -(CH2)3-R2 (wherein R2 is COOH or -CHO), -(CH2)4-NH-(CH2)3-OH or -(CH2)4-NH-(CH2)2-R2 (wherein R2 is as defined above).
4990596 SYNTHETIC PEPTIDE PRODUCING ANTIBODIES OF ENHANCED BINDING TO HUMAN LDH-C4 Erwin Goldberg assigned to Northwestern University