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Abstract: P1251 EVOLUTION AND IMPROVEMENT OF HEMATOLOGIC PROFILE IN MORBID OBESE PATIENTS AFTER BARIATRIC SURGERY
Poster - EPIDEMIOLOGY OF CVD - Cardiometabolic Risk Abstract: P1251 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
EVOLUTION AND IMPROVEMENT OF HEMATOLOGIC PROFILE IN MORBID OBESE PATIENTS AFTER BARIATRIC SURGERY E Pardina1, R Ferrer2, J Baena-Fustegueras2, J Fort2, R Catalán2, R Galard2, A Lecube2, H Allende2, V Vargas2, J Peinado-Onsurbe1 1
Biochemistry Department, Biology Faculty, Barcelona University, Barcelona; 2Institut de Recerca Vall D'Hebron, Universitat Autònoma Barcelona, Barcelona Objectives: An elevated (even within the normal range) leukocyte count is associated with cardiovascular risk factors and, an association between an increase in plasminogen activator inhibitor type 1 (PAI-1) and obesity has been described. Bariatric surgery is shown to be one of the most effective ways to reduce or eliminate these risk factors. We studied different haematological parameters in morbid obese patients and its change after bariatric surgery. Methods: 35 patients with BMI>40 were submitted to bariatric surgery. Haematological parameters (white and red blood cells, hemostasis and PAI-1) were monitored in each patient from obese and one, three, six, nine and twelve months after surgery. Results: Most of the haematological parameters studied are within the range of normality. One month after surgery patients lost 14% of body weight, and simultaneously white blood cells and platelets decreased 17% and reticulocytes 28%. After six months body weight lost was around 29%, and all parameters achieved the values that they will have one year after surgery. PAI-1 obese value was 162±17 ng/mL and decreased 37% during first month until arrive to 35±6 ng/mL one year after surgery. Conclusions: Surgery leads to a normalization of haematological profile and a decrease in PAI1 levels which entail a decrease of risk for cardiovascular disease. Funding: Fondo de Investigación Sanitaria del Instituto de Salud Carlos III of the Spanish Ministry for Health and Consumer Affairs (PI030042, PI030024 and PI070079).
EVOLUTION AND IMPROVEMENT OF HEMATOLOGIC PROFILE IN MORBID OBESE PATIENTS AFTER BARIATRIC SURGERY E Pardina1, R Ferrer2, J Baena-Fustegueras2, J Fort2, R Catalán2, R Galard2, A Lecube2, H Allende2, V Vargas2, J Peinado-Onsurbe1 1
Biochemistry Department, Biology Faculty, Barcelona University, Barcelona; 2Institut de Recerca Vall D'Hebron, Universitat Autònoma Barcelona, Barcelona Objectives: An elevated (even within the normal range) leukocyte count is associated with cardiovascular risk factors and, an association between an increase in plasminogen activator inhibitor type 1 (PAI-1) and obesity has been described. Bariatric surgery is shown to be one of the most effective ways to reduce or eliminate these risk factors. We studied different haematological parameters in morbid obese patients and its change after bariatric surgery. Methods: 35 patients with BMI>40 were submitted to bariatric surgery. Haematological parameters (white and red blood cells, hemostasis and PAI-1) were monitored in each patient from obese and one, three, six, nine and twelve months after surgery. Results: Most of the haematological parameters studied are within the range of normality. One month after surgery patients lost 14% of body weight, and simultaneously white blood cells and platelets decreased 17% and reticulocytes 28%. After six months body weight lost was around 29%, and all parameters achieved the values that they will have one year after surgery. PAI-1 obese value was 162±17 ng/mL and decreased 37% during first month until arrive to 35±6 ng/mL one year after surgery. Conclusions: Surgery leads to a normalization of haematological profile and a decrease in PAI1 levels which entail a decrease of risk for cardiovascular disease. Funding: Fondo de Investigación Sanitaria del Instituto de Salud Carlos III of the Spanish Ministry for Health and Consumer Affairs (PI030042, PI030024 and PI070079).