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Animal models in AIDS
90
VIRUS 00694
Animal Models in AIDS, edited by H. Schellekens and M. Horzinek. Elsevier Science Publishers, 1990, 400 pages. ISBN O-444-812644. US$ 114.50/Dfl. 200.00. This book is a comprehensive and current summary of the “state-of-the-art” of animal models of the acquired immunodeficiency syndrome (AIDS). The book is a selected summary of an international meeting organized by the Netherlands Organization for Applied Research (TNO). It is a collection of well written papers which range in topic from the biosafety aspects of AIDS research to detailed research articles concerning the pathogenesis of lentivirus infections in primates. The book is divided by model types and covers the range of animal models for AIDS from mice to primates. Because the book is a summary of research presentations there is a certain amount of inconsistency between individual chapters; however, this does not interfere with the overall readability of the book. The editors begin their collection by providing research summaries of “direct” HIV models (those that use HIV-l and HIV-2 as inocula). The data presentation varies between articles but is easy to find and relate to the text of each article. Especially well written are articles concerned with HIV-2 infection of various primate species; these findings also illustrate the frustration, at times, of researchers in a desperate search for a reproducible and accurate model of an HIV disease model. Excellent ultrastructural figures highlight the book chapter by Dr. H.R. Gelderblom and colleagues concerning the morphogenesis and fine structure of lentiviruses. The chapters about feline retrovirus models (both feline leukemia virus and feline immunodeficiency virus) are examples which illustrate the utility of the book. Each chapter is concisely written and provides details of experimental results from pathogenic mechanisms to clinical symptoms. Particularly useful are the numerous, well organized tables and graphs. Like all endeavors involving multiple participants, some of the efforts by individual authors appeared limited with scant details of experimental results. Overall, this book is a unique collection that reviews and compares animal models of AIDS. As such, the book provides a single and complete reference source for those interested in comparing knowledge gained by rather divergent animal models of AIDS. Michael
D. Lairmore
VIRUS 00694
Animal Models in AIDS, edited by H. Schellekens and M. Horzinek. Elsevier Science Publishers, 1990, 400 pages. ISBN O-444-812644. US$ 114.50/Dfl. 200.00. This book is a comprehensive and current summary of the “state-of-the-art” of animal models of the acquired immunodeficiency syndrome (AIDS). The book is a selected summary of an international meeting organized by the Netherlands Organization for Applied Research (TNO). It is a collection of well written papers which range in topic from the biosafety aspects of AIDS research to detailed research articles concerning the pathogenesis of lentivirus infections in primates. The book is divided by model types and covers the range of animal models for AIDS from mice to primates. Because the book is a summary of research presentations there is a certain amount of inconsistency between individual chapters; however, this does not interfere with the overall readability of the book. The editors begin their collection by providing research summaries of “direct” HIV models (those that use HIV-l and HIV-2 as inocula). The data presentation varies between articles but is easy to find and relate to the text of each article. Especially well written are articles concerned with HIV-2 infection of various primate species; these findings also illustrate the frustration, at times, of researchers in a desperate search for a reproducible and accurate model of an HIV disease model. Excellent ultrastructural figures highlight the book chapter by Dr. H.R. Gelderblom and colleagues concerning the morphogenesis and fine structure of lentiviruses. The chapters about feline retrovirus models (both feline leukemia virus and feline immunodeficiency virus) are examples which illustrate the utility of the book. Each chapter is concisely written and provides details of experimental results from pathogenic mechanisms to clinical symptoms. Particularly useful are the numerous, well organized tables and graphs. Like all endeavors involving multiple participants, some of the efforts by individual authors appeared limited with scant details of experimental results. Overall, this book is a unique collection that reviews and compares animal models of AIDS. As such, the book provides a single and complete reference source for those interested in comparing knowledge gained by rather divergent animal models of AIDS. Michael
D. Lairmore