- Email: [email protected]
Association between dietary patterns and cognitive impairment in the elderly
P594 P2-268
Poster Presentations: P2 ASSOCIATION BETWEEN DIETARY PATTERNS AND COGNITIVE IMPAIRMENT IN THE ELDERLY
Kai-Ting Chang1, Jen-Hau Chen2, Meei-Shyuan Lee3, Chi-Dan Chen1, Jeng-Min Chiou4, Ta-Fu Chen5, Ya-Fang Chen6, Sung-Chun Tang5, ShinJoe Yeh5, Yen-Ching Chen1, 1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; 2Department of Geriatrics and Gerontology, National Taiwan University, Taipei, Taiwan; 3Department of Public Health, School of Public Health, National Defense Medical Center, Taipei, Taiwan; 4Institute of Statistical Science, Academia Sinica, Taipei, Taiwan; 5Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; 6 Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. Contact e-mail: [email protected] Background: Previous studies on western diet and cognitive impairment were inconsistent. Significant differences were observed between the eastern and western diets, this study aimed to assess the relationship between dietary patterns and cognitive impairment in the elderly. Methods: This is a cross-sectional study. A total of 566 elders (age65) were recruited from a teaching hospital in Taipei, Taiwan from 2011 to 2013. Cognitive impairment was assessed by the Montreal Cognitive Assessment with a score <24 indicates cognitive impairment. Dietary information in the past year was collected based on a semi-quantitative food frequency questionnaire. Principal component analysis and logistic regression model were performed to identify dietary patterns and their association with cognitive impairment. Results: Higher tertiles of the “traditional Chinese” dietary pattern (fermented foods and pickled vegetables) protected against cognitive impairment [T2: adjusted odds ratio (AOR)¼0.30–0.34; T3: AOR¼0.33–0.39] as compared to the lowest tertile. After stratification by age groups (age<75 and 75) or sex, similar protective effects were observed (AOR¼0.25–0.40). In addition, higher tertiles of “traditional Chinese” dietary pattern protected against cognitive impairment among APOE e4 non-carriers (T2: AOR¼0.36, T3: AOR ¼ 0.38), APOE e4 carriers (T2: AOR¼0.05), and supplement users (AOR¼0.31 and 0.33). Conclusions: “Traditional Chinese” dietary pattern protected against cognitive impairment in the elderly.
P2-269
DECREASED PHYSICAL ACTIVITY ASSOCIATED WITH EXECUTIVE DYSFUNCTION CORRELATES WITH COGNITIVE IMPAIRMENT AMONG OLDER ADULTS IN THE COMMUNITY: A RETROSPECTIVE ANALYSIS FROM THE KURIHARA PROJECT — IMPLICATION FOR EXERCISE INTERVENTION FOR DEMENTIA PREVENTION
Yoritoshi Kobayashi1, Keiichi Kumai1, Mari Kasai1, Kei Nakamura1, Masahiro Nakatsuka1, Kenichi Meguro1 The Kurhara Project Members, 1 Tohoku University, Sendai, Japan. Contact e-mail: y-kobayashi@med. tohoku.ac.jp Background: Although physical activity (PA) may be reduced due to
cognitive impairment in older adults, no previous studies have clarified the relationship with executive dysfunction. Using the database of the Kurihara Project, a community-based prevention program of stroke and dementia in Kurihara, the PA of healthy aging adults and adults with dementia was analyzed retrospectively. Methods: We retrospectively evaluated the Basic Information of Users (BUI) of 590 subjects aged 75 years who had participated
in the Kurihara Project 2008. Among these participants, 221 had a Clinical Dementia Rating (CDR) of 0 (healthy), 295 had CDR 0.5 (mild cognitive impairment), and 74 had CDR 1+ (dementia). PA was estimated by motor intensity and time duration from 23 items in daily activities. After classifying their PA into high (3 METs) or low (< 3METs) motor intensities, together with simple or complicated tasks by executive function level, we investigated the relationships with CDR levels. Results: In the complicated task, whether the motor intensity was high (e.g. farming) or low (e.g. shopping), the PA exhibited an inverse relationship with CDR level. By contrast, simple tasks showed different results. Specifically, for PA with a high motor intensity (e.g. walking), there were no CDR group differences; however, for PA with low motor intensity (e.g. cleaning), the CDR 1+ group exhibited decreased levels compared with the same PA level in the CDR 0 and 0.5 groups. Conclusions: PA was related to the burden of executive function for CDR 0.5; however, dementia was related to both burden of executive function and level of motor intensity. Since previous reports on “exercise” interventions for dementia prevention have not considered the burden of executive function, we should be cautious in our interpretation of such results.
P2-270
FEAR OF FALLING ASSOCIATED WITH DEPRESSION, HIGH-RISK MEDICATIONS, AND DECLINES IN WORD LIST MEMORY
Andrew J. Revell1, Clarissa W. Iuchno2, Rayna C. Campbell3, Carla P. Vertentes1, Christi L. Nelson1, 1University of Massachusetts Dartmouth, North Dartmouth, MA, USA; 2Federal University of Health Sciences of Porto Alegre, Rio Grande do Sul, Brazil; 3University of Wisconsin-Eau Claire, Eau Claire, WI, USA. Contact e-mail: arevell@ umassd.edu Background: Falls in older adults are the leading cause of fatal and non-fatal injuries (CDC, 2013). Fear of falling (FOF) is more common among those who have previously fallen (Scheffer et al., 2008) and in those with MCI (Borges et al., 2014), yet few studies have investigated resulting consequences in a community-dwelling sample. Methods: The Southcoast Cognitive Aging Study (SCAS), a cross-sectional study, composed of middle-aged and older adults (Mean age ¼ 71.50; SD age ¼ 9.24, range 50-94; 77% female) from Southeastern Massachusetts were administered vascular health, neuropsychological, and psychosocial assessments. Results: Multiple regression analyses indicate FOF is associated with higher depression levels (b¼.047, t¼2.33, p¼.023), more frequent highrisk medications for falls (b¼.33, t¼2.13, p¼.037), and lower self-rated physical health (b¼.37, t¼-2.66, p¼.009). Secondary regression analyses indicated FOF predicted lowered word list memory recognition performance (p¼.029). Contrary to recent large-scale research (e.g., Clemson et al., 2014), frequency of past falls did predict FOF (b¼.56, t¼3.61, p¼.001). Differences by cultural groups common in the region were also assessed. Portuguese-Americans reported being less able to anticipate falls (p¼.007), which are the most common cause of fatal and non-fatal injuries in older adults (CDC, 2013). Grip force strength as a proxy for physical ability, as well as objective vascular health measurements, such as mean arterial pressure, were not significantly associated with FOF. Conclusions: These factors need replication in longitudinal studies while investigating additional consequences and potential treatment interventions to minimize future fall incidents in those with memory loss.
Poster Presentations: P2 ASSOCIATION BETWEEN DIETARY PATTERNS AND COGNITIVE IMPAIRMENT IN THE ELDERLY
Kai-Ting Chang1, Jen-Hau Chen2, Meei-Shyuan Lee3, Chi-Dan Chen1, Jeng-Min Chiou4, Ta-Fu Chen5, Ya-Fang Chen6, Sung-Chun Tang5, ShinJoe Yeh5, Yen-Ching Chen1, 1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; 2Department of Geriatrics and Gerontology, National Taiwan University, Taipei, Taiwan; 3Department of Public Health, School of Public Health, National Defense Medical Center, Taipei, Taiwan; 4Institute of Statistical Science, Academia Sinica, Taipei, Taiwan; 5Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; 6 Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. Contact e-mail: [email protected] Background: Previous studies on western diet and cognitive impairment were inconsistent. Significant differences were observed between the eastern and western diets, this study aimed to assess the relationship between dietary patterns and cognitive impairment in the elderly. Methods: This is a cross-sectional study. A total of 566 elders (age65) were recruited from a teaching hospital in Taipei, Taiwan from 2011 to 2013. Cognitive impairment was assessed by the Montreal Cognitive Assessment with a score <24 indicates cognitive impairment. Dietary information in the past year was collected based on a semi-quantitative food frequency questionnaire. Principal component analysis and logistic regression model were performed to identify dietary patterns and their association with cognitive impairment. Results: Higher tertiles of the “traditional Chinese” dietary pattern (fermented foods and pickled vegetables) protected against cognitive impairment [T2: adjusted odds ratio (AOR)¼0.30–0.34; T3: AOR¼0.33–0.39] as compared to the lowest tertile. After stratification by age groups (age<75 and 75) or sex, similar protective effects were observed (AOR¼0.25–0.40). In addition, higher tertiles of “traditional Chinese” dietary pattern protected against cognitive impairment among APOE e4 non-carriers (T2: AOR¼0.36, T3: AOR ¼ 0.38), APOE e4 carriers (T2: AOR¼0.05), and supplement users (AOR¼0.31 and 0.33). Conclusions: “Traditional Chinese” dietary pattern protected against cognitive impairment in the elderly.
P2-269
DECREASED PHYSICAL ACTIVITY ASSOCIATED WITH EXECUTIVE DYSFUNCTION CORRELATES WITH COGNITIVE IMPAIRMENT AMONG OLDER ADULTS IN THE COMMUNITY: A RETROSPECTIVE ANALYSIS FROM THE KURIHARA PROJECT — IMPLICATION FOR EXERCISE INTERVENTION FOR DEMENTIA PREVENTION
Yoritoshi Kobayashi1, Keiichi Kumai1, Mari Kasai1, Kei Nakamura1, Masahiro Nakatsuka1, Kenichi Meguro1 The Kurhara Project Members, 1 Tohoku University, Sendai, Japan. Contact e-mail: y-kobayashi@med. tohoku.ac.jp Background: Although physical activity (PA) may be reduced due to
cognitive impairment in older adults, no previous studies have clarified the relationship with executive dysfunction. Using the database of the Kurihara Project, a community-based prevention program of stroke and dementia in Kurihara, the PA of healthy aging adults and adults with dementia was analyzed retrospectively. Methods: We retrospectively evaluated the Basic Information of Users (BUI) of 590 subjects aged 75 years who had participated
in the Kurihara Project 2008. Among these participants, 221 had a Clinical Dementia Rating (CDR) of 0 (healthy), 295 had CDR 0.5 (mild cognitive impairment), and 74 had CDR 1+ (dementia). PA was estimated by motor intensity and time duration from 23 items in daily activities. After classifying their PA into high (3 METs) or low (< 3METs) motor intensities, together with simple or complicated tasks by executive function level, we investigated the relationships with CDR levels. Results: In the complicated task, whether the motor intensity was high (e.g. farming) or low (e.g. shopping), the PA exhibited an inverse relationship with CDR level. By contrast, simple tasks showed different results. Specifically, for PA with a high motor intensity (e.g. walking), there were no CDR group differences; however, for PA with low motor intensity (e.g. cleaning), the CDR 1+ group exhibited decreased levels compared with the same PA level in the CDR 0 and 0.5 groups. Conclusions: PA was related to the burden of executive function for CDR 0.5; however, dementia was related to both burden of executive function and level of motor intensity. Since previous reports on “exercise” interventions for dementia prevention have not considered the burden of executive function, we should be cautious in our interpretation of such results.
P2-270
FEAR OF FALLING ASSOCIATED WITH DEPRESSION, HIGH-RISK MEDICATIONS, AND DECLINES IN WORD LIST MEMORY
Andrew J. Revell1, Clarissa W. Iuchno2, Rayna C. Campbell3, Carla P. Vertentes1, Christi L. Nelson1, 1University of Massachusetts Dartmouth, North Dartmouth, MA, USA; 2Federal University of Health Sciences of Porto Alegre, Rio Grande do Sul, Brazil; 3University of Wisconsin-Eau Claire, Eau Claire, WI, USA. Contact e-mail: arevell@ umassd.edu Background: Falls in older adults are the leading cause of fatal and non-fatal injuries (CDC, 2013). Fear of falling (FOF) is more common among those who have previously fallen (Scheffer et al., 2008) and in those with MCI (Borges et al., 2014), yet few studies have investigated resulting consequences in a community-dwelling sample. Methods: The Southcoast Cognitive Aging Study (SCAS), a cross-sectional study, composed of middle-aged and older adults (Mean age ¼ 71.50; SD age ¼ 9.24, range 50-94; 77% female) from Southeastern Massachusetts were administered vascular health, neuropsychological, and psychosocial assessments. Results: Multiple regression analyses indicate FOF is associated with higher depression levels (b¼.047, t¼2.33, p¼.023), more frequent highrisk medications for falls (b¼.33, t¼2.13, p¼.037), and lower self-rated physical health (b¼.37, t¼-2.66, p¼.009). Secondary regression analyses indicated FOF predicted lowered word list memory recognition performance (p¼.029). Contrary to recent large-scale research (e.g., Clemson et al., 2014), frequency of past falls did predict FOF (b¼.56, t¼3.61, p¼.001). Differences by cultural groups common in the region were also assessed. Portuguese-Americans reported being less able to anticipate falls (p¼.007), which are the most common cause of fatal and non-fatal injuries in older adults (CDC, 2013). Grip force strength as a proxy for physical ability, as well as objective vascular health measurements, such as mean arterial pressure, were not significantly associated with FOF. Conclusions: These factors need replication in longitudinal studies while investigating additional consequences and potential treatment interventions to minimize future fall incidents in those with memory loss.