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Clinical significance of blood cholesterol
AMERICAN HEARTJOURNAL
474
CLINICAL
SIGNIFICANCE
OF BLOOD
CHOLESTEROL
HARRY E. UNGERLEIDERANDRICHARDGUBNER,NEWYORK,N.Y. Medical
Departmen!,
Equitable
Life
Assurance
Society
of the United
States
Several studies have indicated that hypercholesterolemia occurs frequently in arteriosclerotic heart disease, but it has not been ascertained whether hypercholesterolemia is an etiologic factor in human arteriosclerosis or merely a concomitant of associated metabolic disorders (such as diabetes mellitus) which are responsible for degenerative vascular changes. An analysis has been made of 104 insurance applicants with levels of blood cholesterol below 175 mg. per cent and 104 individuals with blood cholesterol above 260 mg. per cent. In addition to physical examination, blood sugar tolerance studies and electrocardiograms and teleroentgenograms were made on all subjects. Comparison is made between age, weight and body build, sugar tolerance, and the incidence of cardiovascular impairments in the group with low blood cholesterol values and the group with hypercholesterolemia. Included among cardiovascular impairment studied are abnormal blood pressure, heart murmurs, cardiac enlargement, electrocardiographic abnormalities, and roentgenologic evidence of arteriosclerosis of the aorta. No striking difference in the incidence of cardiovascular impairments between the two groups was found. Although there is much evidence that cholesterol plays an important role in arteriosclerosis, it appears that hypercholesterolemia must be protracted over many years before vascular damage results, and that cholesterol is not the sole factor in the genesisof arteriosclerosis. STUDIES ON THE CHOLESTEROL CONTENT OF THE CORONARY ARTERIES AND THE BLOOD IN ACUTE CORONARY THROMBOSIS LESTER M. MORRISON,ALBERT L. CHANEY,~HARI,ES LANGMADE,AND W. A. JOHNSON,Los ANGELES, CALIF. Los Angeles
County
Hospital
In this study two groups of patients who had died from (a) acute coronary deaths were examined, post-mortem, to thrombosis and (b) non-“coronary” determine (1) the cholesterol content of the occluded artery and (2) the cholesterol and ester fraction of the blood. Correlations are demonstrated between (1) and (2) and their significance discussed. CHANGES IN BLOOD CHOLESTEROL LEVELS IN PATIENTS WITH CORONARY OCCLUSION FOLLOWING CHOLINE THERAPY LESTER M. MORRISON, LILLIAN HALL,AND WILLIAM GONZALES, Los ANGELES,~ALIF. Los Angeles
County Hospital
Over 100 patients have been treated with choline at regular intervals over a two-year period. The changes in blood cholesterol levels are presented and their significance discussed.
474
CLINICAL
SIGNIFICANCE
OF BLOOD
CHOLESTEROL
HARRY E. UNGERLEIDERANDRICHARDGUBNER,NEWYORK,N.Y. Medical
Departmen!,
Equitable
Life
Assurance
Society
of the United
States
Several studies have indicated that hypercholesterolemia occurs frequently in arteriosclerotic heart disease, but it has not been ascertained whether hypercholesterolemia is an etiologic factor in human arteriosclerosis or merely a concomitant of associated metabolic disorders (such as diabetes mellitus) which are responsible for degenerative vascular changes. An analysis has been made of 104 insurance applicants with levels of blood cholesterol below 175 mg. per cent and 104 individuals with blood cholesterol above 260 mg. per cent. In addition to physical examination, blood sugar tolerance studies and electrocardiograms and teleroentgenograms were made on all subjects. Comparison is made between age, weight and body build, sugar tolerance, and the incidence of cardiovascular impairments in the group with low blood cholesterol values and the group with hypercholesterolemia. Included among cardiovascular impairment studied are abnormal blood pressure, heart murmurs, cardiac enlargement, electrocardiographic abnormalities, and roentgenologic evidence of arteriosclerosis of the aorta. No striking difference in the incidence of cardiovascular impairments between the two groups was found. Although there is much evidence that cholesterol plays an important role in arteriosclerosis, it appears that hypercholesterolemia must be protracted over many years before vascular damage results, and that cholesterol is not the sole factor in the genesisof arteriosclerosis. STUDIES ON THE CHOLESTEROL CONTENT OF THE CORONARY ARTERIES AND THE BLOOD IN ACUTE CORONARY THROMBOSIS LESTER M. MORRISON,ALBERT L. CHANEY,~HARI,ES LANGMADE,AND W. A. JOHNSON,Los ANGELES, CALIF. Los Angeles
County
Hospital
In this study two groups of patients who had died from (a) acute coronary deaths were examined, post-mortem, to thrombosis and (b) non-“coronary” determine (1) the cholesterol content of the occluded artery and (2) the cholesterol and ester fraction of the blood. Correlations are demonstrated between (1) and (2) and their significance discussed. CHANGES IN BLOOD CHOLESTEROL LEVELS IN PATIENTS WITH CORONARY OCCLUSION FOLLOWING CHOLINE THERAPY LESTER M. MORRISON, LILLIAN HALL,AND WILLIAM GONZALES, Los ANGELES,~ALIF. Los Angeles
County Hospital
Over 100 patients have been treated with choline at regular intervals over a two-year period. The changes in blood cholesterol levels are presented and their significance discussed.