- Email: [email protected]
College Fellowship Program
11 ()
Diseases of the Chest
COMMITTEE ON ALLERGY
TABLE 2 (Continued) FIGURE 5.
A HETEROGENOUS GROUP: cyproheptadine, meclizine and hydroxyzine could have been included here, but have been omitted purposely because they are not primarily indicated in allergy. Members of this group are claimed to have few, if any, side effects.
Generic Name 1. Chlorcyclizine
Trade Name Di-Paraline (Abbott)
Dose 50 mg. q. 12 h.
Perazil (Burroughs Wellcome & Co.)
50 mg. q. 12 h.
2. Phenindamine
Thephorin (Roche)
10 - 50 mg. q. 4 - 12 h.
3. Buclizine 4. Dyphenylpyraline
Softran (Stuart) Diafen (Riker) End Allergy (AmfreGrant) Hispril (Smith Kline & French) Forhistal (Ciba)
50 mg. t.i.d. 2 mg. 3 or 4 h. 2 mg. q. 4 h.
5. Dimethindene
Compounds Emprazil (Burroughs Wellcome & Co.) Fedrazil (Burroughs Wellcome & Co. ) Histalet (Scott-Lee) Nolamine (Carnrick) Thephorin-AC (Roche)
5 mg. q. 12 h.
1 mg. q. 4 h.
(Adapted from Harris, M. C. and Shure N., Sensitivity Chest Diseases, F. A. Davis Company, Philadelphia, 1964).
based on the conVIctIon that histamine is the sole chemical mediator of allergy. In a limited sense, this belief is justified for most symptoms are connected with some liberation of histamine. Studying the differences in the formulas and side effects of the antihistamines listed in Table 2 may be of help to the physician in prescribing them. For night time, for example, one may prefer to prescribe an antihistamine which produces drowsiness, to assure the patient a good night's rest; during the daytime such an antihistamine might well be avoided. If a particular antihistamine is ineffective and a change is desired, one may substitute an antihistamine from a different group rather than from the group originally prescribed. Occasionally, it may be worthwhile to combine two or three
antihistamines with different formulas for their synergistic effect. Several pharmaceutical firms have done this. There are many more and undoubtedly much more recent antihistamines than those mentioned in Table 2; also there are many multiple combinations made up in capsule, tablet, and liquid form. However, it is best to avoid using such combinations of drugs, if possible, and prescribe only the individual drugs that are warranted and indicated. For that reason, combinations of antihistamines have been listed but not stressed. M. COLEMAN HARRIS, M.D., San Francisco, California NORMAN SHURE, M.D. Los Angeles, California LEON UNGER, M.D., F.C.C.P.,. Chicago, Illinois, Chairman, Committee on Allergy
F.C.C.P.
COLLEGE FELLOWSHIP PROGRAM The American College of Chest Physicians is offering three fellowships, as indicated below: 1. Eudowood Fellowship for Tuberculosis with a grant of $2,500.00 per year for postgraduate training in the United States in tuberculosis. Candidates must hold the ECFMG certificate. 2. Li Shu-Fan Fellou1ship for Postgraduate Study in Chest Disease appropriates $1,000.00 annually for a t\\'elve month period of training in any country. If the postgraduate training is
taken in the United States, the ECFMG certificate would be required. 3. Alfred A. Richman Fellowship for Chest Disease offers $100.00 a month for a period of one year's postgraduate study in any country. Candidates must hold the ECFMG certificate if training in the United States. Physicians interested in these fellowships should contact Dr. Andrew L. Banyai, Chairman of the Council on International Affairs, at the Executive Offices of the College.
Diseases of the Chest
COMMITTEE ON ALLERGY
TABLE 2 (Continued) FIGURE 5.
A HETEROGENOUS GROUP: cyproheptadine, meclizine and hydroxyzine could have been included here, but have been omitted purposely because they are not primarily indicated in allergy. Members of this group are claimed to have few, if any, side effects.
Generic Name 1. Chlorcyclizine
Trade Name Di-Paraline (Abbott)
Dose 50 mg. q. 12 h.
Perazil (Burroughs Wellcome & Co.)
50 mg. q. 12 h.
2. Phenindamine
Thephorin (Roche)
10 - 50 mg. q. 4 - 12 h.
3. Buclizine 4. Dyphenylpyraline
Softran (Stuart) Diafen (Riker) End Allergy (AmfreGrant) Hispril (Smith Kline & French) Forhistal (Ciba)
50 mg. t.i.d. 2 mg. 3 or 4 h. 2 mg. q. 4 h.
5. Dimethindene
Compounds Emprazil (Burroughs Wellcome & Co.) Fedrazil (Burroughs Wellcome & Co. ) Histalet (Scott-Lee) Nolamine (Carnrick) Thephorin-AC (Roche)
5 mg. q. 12 h.
1 mg. q. 4 h.
(Adapted from Harris, M. C. and Shure N., Sensitivity Chest Diseases, F. A. Davis Company, Philadelphia, 1964).
based on the conVIctIon that histamine is the sole chemical mediator of allergy. In a limited sense, this belief is justified for most symptoms are connected with some liberation of histamine. Studying the differences in the formulas and side effects of the antihistamines listed in Table 2 may be of help to the physician in prescribing them. For night time, for example, one may prefer to prescribe an antihistamine which produces drowsiness, to assure the patient a good night's rest; during the daytime such an antihistamine might well be avoided. If a particular antihistamine is ineffective and a change is desired, one may substitute an antihistamine from a different group rather than from the group originally prescribed. Occasionally, it may be worthwhile to combine two or three
antihistamines with different formulas for their synergistic effect. Several pharmaceutical firms have done this. There are many more and undoubtedly much more recent antihistamines than those mentioned in Table 2; also there are many multiple combinations made up in capsule, tablet, and liquid form. However, it is best to avoid using such combinations of drugs, if possible, and prescribe only the individual drugs that are warranted and indicated. For that reason, combinations of antihistamines have been listed but not stressed. M. COLEMAN HARRIS, M.D., San Francisco, California NORMAN SHURE, M.D. Los Angeles, California LEON UNGER, M.D., F.C.C.P.,. Chicago, Illinois, Chairman, Committee on Allergy
F.C.C.P.
COLLEGE FELLOWSHIP PROGRAM The American College of Chest Physicians is offering three fellowships, as indicated below: 1. Eudowood Fellowship for Tuberculosis with a grant of $2,500.00 per year for postgraduate training in the United States in tuberculosis. Candidates must hold the ECFMG certificate. 2. Li Shu-Fan Fellou1ship for Postgraduate Study in Chest Disease appropriates $1,000.00 annually for a t\\'elve month period of training in any country. If the postgraduate training is
taken in the United States, the ECFMG certificate would be required. 3. Alfred A. Richman Fellowship for Chest Disease offers $100.00 a month for a period of one year's postgraduate study in any country. Candidates must hold the ECFMG certificate if training in the United States. Physicians interested in these fellowships should contact Dr. Andrew L. Banyai, Chairman of the Council on International Affairs, at the Executive Offices of the College.