Abstracts / Schizophrenia Research 102/1–3, Supplement 2 (2008) 1–279
Orhan Z.(2004), Aging and schizophrenia: the relation of age to clinical symptoms and cognitive functions in schizophrenia. Turk Psikiyatri Derg. 15(2):91-7.  Möller-Leimkühler AM. (2005), Burden of relatives and predictors of burden. Baseline results from the Munich 5-year-follow-up study on relatives of ﬁrst hospitalized patients with schizophrenia or depression. European Archives of Psychiatry & Clinical Neuroscience.255(4):223-31.  Karow A, Pajonk FG. (2006), Insight and quality of life in schizophrenia: recent ﬁndings and treatment implications. Current Opinions in Psychiatry, 19(6):637-41.
530 – QUALITY OF LIFE & FAMILY BURDEN IN CAREGIVERS OF PATIENTS WITH SCHIZOPHRENIA: A STUDY FROM INDIA Selwyn Stanley Univ. of Plymouth, Plymouth, UK [email protected]
Introduction: The study was conducted at the community care center, Gunaseelam, in Tamilnadu, India which is attached to a Hindu temple. The site is a known place for religious healing of the mentally ill for the past 200 years. Now a modiﬁed integrated treatment approach is offered here exclusively for schizophrenic patients, which is a blend of traditional temple rituals and modern psychiatric intervention. A comparative pre and post intervention analysis to determine the extent of change in caregivers of schizophrenic patients attending a community based rehabilitation program with regard to their family burden and perceived quality of life was undertaken. Methods: An integrated intervention package comprising of pharmacotherapy, psychosocial therapies and spiritual therapy was provided for a period of 48 days to the patients and their caregivers. Thirty primary caregivers were included as respondents. The Family Burden Scale by Pai and Kapur (1981) and the Perceived Quality of Life Scale by Patrick et al. (2004), were administered at the point of admission of the patients to their primary caregivers as well as 90 days after discharge during the ﬁrst follow up contact. Results: Results indicate signiﬁcant reduction in caregiver burden and enhanced QOL following intervention. Further, a signiﬁcant negative correlation between the family burden and QOL scores of the caregivers was obtained indicating that these two dimensions mutually inﬂuence one another. Conclusions: It is suggested on the basis of this study that spiritual therapy speciﬁc to the religious orientation of patients combined with pharmacotherapy and other psychosocial therapies may enhance the QOL of caregivers in schizophrenia. References  Pai S & Kapur R (1981) The burden on the family of a psychiatric patient development of an interview schedule British Journal of Psychiatry 138, 332–335.  Patrick, D. & Danis, M. (2004), Perceived Quality of Life Scale http://depts.washington.edu/yqol/d ocs/PQOL_Info.pdf
531 – COMPUTERIZED AMBULATORY ASSESSMENT OF QUALITY OF LIFE IN SCHIZOPHRENIA Joel Swendsen, Antoinette Prouteau, Jean-Marc Destaillats, Olivier Grondin, Valérie Bergua, Jack Doron National Scientiﬁc Research Center (CNRS 5231), Bordeaux, France [email protected]
Introduction: Improving the quality of life of persons with schizophrenia is an important treatment objective, but research on this topic has been hindered by low patient insight and retrospective memory problems. Recent applications of Ecological Momentary Assessment (EMA) and the Experience Sampling Method (ESM) provide opportunities to assess quality of life directly while also permit ting the evaluation of traditional instruments.
Methods: Structured clinical interviews and the Lancashire Quality Of Life Proﬁle were administered to 43 patients with schizophrenia and 43 healthy control participants. All participants then completed a weeklong phase of computerized ambulatory monitoring using PDA microcomputers that assessed momentary experiences and quality of life 5 times per day. Results: Compliance with ambulatory monitoring procedures was high (85% of 2995 program med interviews were completed) and, as would be expected, patients with schizophrenia reported lower overall quality of life than controls (B=-1,199, p=0,005). In both groups, however, only moderate correlations were found between traditional retrospective measures and daily life evaluations of this concept (schizophrenia: r=0,42, p=0,01; controls: r=0,47, p=0,001). Discrepancies between traditional and daily life measures of quality of life were generally greater for patients with schizophrenia in comparison to controls. Conclusions: Methodological constraints have favored clinical assessments based on retrospective questionnaires or interviews, but their pertinence for understanding daily life experience has remained an important consideration for schizophrenia research. Novel ambulatory monitoring techniques provide new opportunities to collect ecologically valid information that should improve our understanding of the daily experience and clinical status of patients with this disorder. References  Granholm E, Loh C, Swendsen J. Feasibility and Validity of Computerized Ecological Momentary Assessment in Schizophrenia. Schizophrenia Bulletin (in press)  Prouteau A, Verdoux H, Briand C, Lesage A, Lalonde P, Nicole L, Reinharz D, Stip E. Cognitive predictors of psychosocial functioning outcome in schizophrenia: a follow-up study of subjects participating in a rehabilitation program. Schizophrenia Research 2005; 77: 343-53.  Husky M, Grondin O, Swendsen J. The relation between social behavior and negative affect in psychosis-prone individuals: An experience sampling investigation. European Psychiatry. 2004; 19: 1-7.
532 – VALIDITY OF THE SPANISH VERSION OF THE PERSONAL AND SOCIAL PERFORMANCE SCALE IN SCHIZOPHRENIC PATIENTS Rogelio Apiquian 1 , Rosa Elena Ulloa 2 , Sandra Erosa 1 , Miguel Herrera-Estrella 3 , Araceli Moreno-Gomez 3 , Humberto Nicolini 1 1 Grupo Medico Carracci, Mexico; 2 Child Psychiatry J.N.Navarro, Mexico; 3 Psychiatry Hospital Fray Bernardino Alvarez, Mexico [email protected]
Introduction: The main goal of current treatments of schizophrenia is to improve the cognitive functioning of the patients. The Personal Social Performance (PSP) scale was created as an indirect measure of cognition through the assessment of the patient’s functioning. The objective was to determine the validity of the Spanish version of the PSP. Methods: The scale was translated to Spanish and back translated to English. One hundred patients with DSM-IVTR diagnosis of schizophrenia were assessed using the PSP, GAF and PANSS. Correlations between PSP and these scales were obtained. Results: The sample included 41% of males, most patients were diagnosed with paranoid (58%) and undifferentiated (25%) types of schizophrenia; 62% were on atypical antipsychotics and 59% were inpatients. The mean scores of total PANSS, GAF and PSP were 57.5 (+ 19.9), 55.4 (+ 18.7) and 57.5 (+ 19.9), respectively. Inpatients showed lower scores of PSP than outpatients 52.6 (14.7) vs. 64.5 (24.06); t= 3.05, p=0.003. Total PSP showed signiﬁcant correlations with GAF (0.66), and dimensions of the PANSS including:positive (r=-0.63), negative (r=0-.74), cognitive (r=0-.72), excitability (r=-0.52) and depressive (r= -0.32). Conclusions: The Spanish version of PSP is able to assess the