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Experimental and clinical observations on the effect of insulin and aminopaminee on acupuncture analgesia
-_. Poster 91 GREEN Mon-Tues Exhibit Hall
BXPWIMBNTAL AWB CLINICALOB3ERVATION9ON THE EFFBCT OF INSOLIN ABB AMINOPRyI&IBBON ACDPUNCTWRBAtJUESIA. , Guase;ai Tu*l, Weiqiu Huan@2, 3hiyu I&*2. *2, Bexiu Zhau@2 and Jingchq Zhou*2, Abs No 134 Laboratoryof Neurobiology1and AoupunotureAnalgesia Research Broup2, 3ushou Medical College, 3u%hou 21fioO7, People'sRepublio of cA%im There is evidence that insulin and aminophyllinecan tonia(S-HT)oontent,whioh aan enhfmae the amaQesic This studywasundertakento evaluate the infXuex%oe on aoupunoture Mt&ge8ia in experimenta8 Well of inmlin and aminop&ne as
in olinio. ME’pIyalls:
The analgesic effeot of electroacupuncture(Rem&hong"DE426" and Chengjiang "RX 24") was measured in adult rats with tail stimitationvooalisationtest. The brain 5-HT content was deterninedwith spectrophotofluorometer.Clinioal observationwas carried out on '315cases of abdomigal tuboligatlonunder acupunctureanesthesiawith double blind method. m: After injectionof insulin(l.4-1.6units/kg, i.p.1 a siguifioant inorease in aeupunotureanalgesiawas observed,and the brain 5-ET level was inorease in aou.unaturPr anal&esiawas inoreasedby 479%.A more significant observed after aminophyllineinjeotion(60m&g, i,p.), and the brain 5-RT level was increasedb 63%. Clinical observationrewealed a greater od rate sGrade I+II) in case9 pretreatedvlth ankinophylline .o.) than that in the placebo control oases. 't Bxperimntal results demonstratedthat insulin and aminophylhanoe the snalgeaic effeot of aoupm%oture. A beneficialeffect 1 of aminophyllineon acupuuotureanesthesiavas also demonstratedin olinic. The role of serotonerglo neuronal system underlying these effects was suggested.
STUDIESON THE CORRELATION BETUBEN THEACETYLCHOLINE(ACh> ANDTHE PRINARY SHNSORY INPUTOF Am ANALGESIA(M) X.W.Guaa, J.Zhang, J.shi,X. C.Liang and Y.W.Zhang,Reserch Departaent of Acupuncture Analgesic Wechaaisa, Tongj i Nedicat Uaivarsi ty, Wan, China.
GREEN Mon-Tues Exhibit Hall Abs No
135
AIN OF INYESTIGATION,In order to investigate the neurochsaical aech- aoisa of AA,the relationship between the ACh and the primary input of AA information was studied. NETEODS,Acupoints of rat(SD) corresponding to “Zhusanli ” and “Huantiao” were acupuactured by mans of “DN-A” type AA apparatus and pain threshold was expressed in ailtampere required for irrtating screuing of rat. The level of ACh,theactivities of acstylchotine esteraes( AChE) , choline acetylase (ChAc) aad ?? uscarinic receptor
BXPWIMBNTAL AWB CLINICALOB3ERVATION9ON THE EFFBCT OF INSOLIN ABB AMINOPRyI&IBBON ACDPUNCTWRBAtJUESIA. , Guase;ai Tu*l, Weiqiu Huan@2, 3hiyu I&*2. *2, Bexiu Zhau@2 and Jingchq Zhou*2, Abs No 134 Laboratoryof Neurobiology1and AoupunotureAnalgesia Research Broup2, 3ushou Medical College, 3u%hou 21fioO7, People'sRepublio of cA%im There is evidence that insulin and aminophyllinecan tonia(S-HT)oontent,whioh aan enhfmae the amaQesic This studywasundertakento evaluate the infXuex%oe on aoupunoture Mt&ge8ia in experimenta8 Well of inmlin and aminop&ne as
in olinio. ME’pIyalls:
The analgesic effeot of electroacupuncture(Rem&hong"DE426" and Chengjiang "RX 24") was measured in adult rats with tail stimitationvooalisationtest. The brain 5-HT content was deterninedwith spectrophotofluorometer.Clinioal observationwas carried out on '315cases of abdomigal tuboligatlonunder acupunctureanesthesiawith double blind method. m: After injectionof insulin(l.4-1.6units/kg, i.p.1 a siguifioant inorease in aeupunotureanalgesiawas observed,and the brain 5-ET level was inorease in aou.unaturPr anal&esiawas inoreasedby 479%.A more significant observed after aminophyllineinjeotion(60m&g, i,p.), and the brain 5-RT level was increasedb 63%. Clinical observationrewealed a greater od rate sGrade I+II) in case9 pretreatedvlth ankinophylline .o.) than that in the placebo control oases. 't Bxperimntal results demonstratedthat insulin and aminophylhanoe the snalgeaic effeot of aoupm%oture. A beneficialeffect 1 of aminophyllineon acupuuotureanesthesiavas also demonstratedin olinic. The role of serotonerglo neuronal system underlying these effects was suggested.
STUDIESON THE CORRELATION BETUBEN THEACETYLCHOLINE(ACh> ANDTHE PRINARY SHNSORY INPUTOF Am ANALGESIA(M) X.W.Guaa, J.Zhang, J.shi,X. C.Liang and Y.W.Zhang,Reserch Departaent of Acupuncture Analgesic Wechaaisa, Tongj i Nedicat Uaivarsi ty, Wan, China.
GREEN Mon-Tues Exhibit Hall Abs No
135
AIN OF INYESTIGATION,In order to investigate the neurochsaical aech- aoisa of AA,the relationship between the ACh and the primary input of AA information was studied. NETEODS,Acupoints of rat(SD) corresponding to “Zhusanli ” and “Huantiao” were acupuactured by mans of “DN-A” type AA apparatus and pain threshold was expressed in ailtampere required for irrtating screuing of rat. The level of ACh,theactivities of acstylchotine esteraes( AChE) , choline acetylase (ChAc) aad ?? uscarinic receptor