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Neonatal renal tumours
ABSTRACTS
determination of homovanillic acid failed to return to normal, there was 100~ fatality. Returning to normal gave about an 80~ survival. The degree of cellular differentiation improved prognosis.--S. Kim Combination Therapy of Urogenital Embryonal Rhabdomyosarcoma in Children. F. Ghavimi, P.R. Exelby, G.J. D'Angio, W.F. Whitmore, Jr., P.H. Lieberman, J.L. Lewis. Jr.. 1I. Mike. and M.L. Murphy. Cancer 32, 1178 1185 (November), 1973. This is a review of 27 patients under 15 yr of age with tumors arising from all urogenital sources. The 17 survivors for 18 129 mo include 12/13 stage I, 3/6 stage 11, 2/5 stage I11, and 0/3 stage IV. The urogenital group showed significantly better survival rates when compared to the 107 cases of all types of rhabdomyosarcoma in children less than 15 yr of age from 1960 to 1970. Treatment is primarily surgical extirpation with radio- and chemotherapy. The authors advocate total or partial pelvic exenteration for tumors of bladder, prostate, or vagina. For uterine lesions, total hysterectomy, bilateral salpingooophorectomy, vaginectomy, and a pelvic lymph node dissection is the surgical treatment.--S. Kim Surgery of Bladder and Prostatic Neoplasms in Children. H. W. Clatworthy, Jr., 11".Braren, and J.P. Smith. Cancer 32, 1157 1160 (November), 1973. A review of 67 cases of rhabdomyosarcoma of all types revealed 29/38 patients are living and on a triple-therapy protocol. This is in contrast to four survivors in the first 29 cases. Of the 12 cases involving bladder and prostate, there were nine males and three females, ages 5 mo to 6 yr. The results showed two of eight survivors prior to 1967 and four of four since that time. There were three of three with stage I disease living and well, three of seven with stage II, and none of two with stage III tumors. Only one patient had a clean surgical excision, yet with actinomycin D and vincristine and radiotherapy, there are five other survivors living and well.--S. Kim Sarcoma of the Bladder and Prostate in Children. M. Tefft, and N. Jaffe. Cancer 32, 11611177 (November), 11973. The authors reviewed 125 cases of bladder and
929
prostatic rhabdomyosarcomas. In 37 cases arising from the bladder, only four patients survived when less than total cystectomy was carried out. All four, incidentally, had total cystectomy done as a second procedure. This compares to 22/31 survivors with total cystectomy initially. Five of 25 patients with rhabdomyosareoma arising from the prostate are living after operation. All had some form of chemotherapy, and three survivors had radiotherapy. In the authors' series, seven of 12 with bladder tumors are living and well 1 18 yr. The series included one patient with prostatic rhabdomyosarcoma and he is now the sixth survivor in the literature. The authors feel that radiotherapy in the treatment of these lesions is most important because of the high local recurrence rate. S. Kim
Neonatal Renal Tumours. C. Hilton and J.M. Keeling. Br. J. Urol. 46, 157-161, 1974. Seven cases of neonatal renal tumor are reviewed. Six were successfully treated with surgery alone. The seventh patient died consequent to chemotherapy. The characteristic histologic appearance of neonatal renal tumor is contrasted with that o f nephroblastoma. Because of the rarity of nephroblastoma in children under the age of 1 yr, the hazards o f radiotherapy and chemotherapy in neonates and the more favorable prognosis of renal tumors discovered during the first year o f life, the authors advocate surgical therapy alone for these hamartomatous renal tumors of the neonate.--R.L. Kroovand
Wilms' Tumor Metastasis to U n c o m m o n Sites. N. Mavassaghi, S. Leikin and R. Chandra. J. of Pediatr. 84, 416 (March), 1974. The common sites of metastases in Wilms' tumor are regional lymph nodes, lungs, and liver. The authors report a child with metastases to unusual sites including bones, bone marrow, parotid gland, and tonsils. The authors have suggested that skeletal survey and bone marrow aspiration should be an integral part of the routine study o f any child with a solid t u m o r . George Holcomb
determination of homovanillic acid failed to return to normal, there was 100~ fatality. Returning to normal gave about an 80~ survival. The degree of cellular differentiation improved prognosis.--S. Kim Combination Therapy of Urogenital Embryonal Rhabdomyosarcoma in Children. F. Ghavimi, P.R. Exelby, G.J. D'Angio, W.F. Whitmore, Jr., P.H. Lieberman, J.L. Lewis. Jr.. 1I. Mike. and M.L. Murphy. Cancer 32, 1178 1185 (November), 1973. This is a review of 27 patients under 15 yr of age with tumors arising from all urogenital sources. The 17 survivors for 18 129 mo include 12/13 stage I, 3/6 stage 11, 2/5 stage I11, and 0/3 stage IV. The urogenital group showed significantly better survival rates when compared to the 107 cases of all types of rhabdomyosarcoma in children less than 15 yr of age from 1960 to 1970. Treatment is primarily surgical extirpation with radio- and chemotherapy. The authors advocate total or partial pelvic exenteration for tumors of bladder, prostate, or vagina. For uterine lesions, total hysterectomy, bilateral salpingooophorectomy, vaginectomy, and a pelvic lymph node dissection is the surgical treatment.--S. Kim Surgery of Bladder and Prostatic Neoplasms in Children. H. W. Clatworthy, Jr., 11".Braren, and J.P. Smith. Cancer 32, 1157 1160 (November), 1973. A review of 67 cases of rhabdomyosarcoma of all types revealed 29/38 patients are living and on a triple-therapy protocol. This is in contrast to four survivors in the first 29 cases. Of the 12 cases involving bladder and prostate, there were nine males and three females, ages 5 mo to 6 yr. The results showed two of eight survivors prior to 1967 and four of four since that time. There were three of three with stage I disease living and well, three of seven with stage II, and none of two with stage III tumors. Only one patient had a clean surgical excision, yet with actinomycin D and vincristine and radiotherapy, there are five other survivors living and well.--S. Kim Sarcoma of the Bladder and Prostate in Children. M. Tefft, and N. Jaffe. Cancer 32, 11611177 (November), 11973. The authors reviewed 125 cases of bladder and
929
prostatic rhabdomyosarcomas. In 37 cases arising from the bladder, only four patients survived when less than total cystectomy was carried out. All four, incidentally, had total cystectomy done as a second procedure. This compares to 22/31 survivors with total cystectomy initially. Five of 25 patients with rhabdomyosareoma arising from the prostate are living after operation. All had some form of chemotherapy, and three survivors had radiotherapy. In the authors' series, seven of 12 with bladder tumors are living and well 1 18 yr. The series included one patient with prostatic rhabdomyosarcoma and he is now the sixth survivor in the literature. The authors feel that radiotherapy in the treatment of these lesions is most important because of the high local recurrence rate. S. Kim
Neonatal Renal Tumours. C. Hilton and J.M. Keeling. Br. J. Urol. 46, 157-161, 1974. Seven cases of neonatal renal tumor are reviewed. Six were successfully treated with surgery alone. The seventh patient died consequent to chemotherapy. The characteristic histologic appearance of neonatal renal tumor is contrasted with that o f nephroblastoma. Because of the rarity of nephroblastoma in children under the age of 1 yr, the hazards o f radiotherapy and chemotherapy in neonates and the more favorable prognosis of renal tumors discovered during the first year o f life, the authors advocate surgical therapy alone for these hamartomatous renal tumors of the neonate.--R.L. Kroovand
Wilms' Tumor Metastasis to U n c o m m o n Sites. N. Mavassaghi, S. Leikin and R. Chandra. J. of Pediatr. 84, 416 (March), 1974. The common sites of metastases in Wilms' tumor are regional lymph nodes, lungs, and liver. The authors report a child with metastases to unusual sites including bones, bone marrow, parotid gland, and tonsils. The authors have suggested that skeletal survey and bone marrow aspiration should be an integral part of the routine study o f any child with a solid t u m o r . George Holcomb