S104 8th European Congress on Menopause (EMAS) / Maturitas 63, Supplement 1 (2009) S1–S136 Postmenopausal urogenital atrophy symptoms induced a pres...

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8th European Congress on Menopause (EMAS) / Maturitas 63, Supplement 1 (2009) S1–S136

Postmenopausal urogenital atrophy symptoms induced a prestudy QoL mean score of 36.44±11.78/36.93±12.05/36.62±12.48, and after 6 months 45.25±8.545/45.5±9.72/35.88±7.47. There was statistical significant increase in QoL scores after promestriene (p<0.0005, mean increase 8.81points, 95% CI, 7.27-10.35), and estriol (p<0.0005, mean increase 8.57points, 95%CI, 7.15-10), and no statistical difference in placebo (p=0.396). When compared to placebo, there was statistical increase (p<0.0005) in QoL at 6 month scores in both promestriene/estriol groups. Conclusions: Vaginal treatment influenced positively the QoL, and when compared vs placebo; the restoration of vaginal and urinary symptoms are observed after 3 months with best results at 6 months. Keywords: Urogenital atrophy, quality of life, postmenopause.

410 A DOUBLE BLIND CLINICAL TRIAL: TREATMENT OF FIBROMYALGIA IN POST-MENOPAUSAL WOMEN WITH EVISTA S. Sadreddini. Tabriz University Faculty of Medicine, Rheumatology, Tabriz, Iran, Islamic Republic of Objectives: This study compared Raloxifen (Evista) with placebo in the treatment of fibromyalgia. Methods: A total of 100 menopausal women with fibromyalgia enrolled a double blind randomized study comparing Raloxifen, and placebo over 16 weeks of treatment.Fifty patients received Raloxifen and 49 (98%) completed the study, 50 received Placebo and 47 (94%) completed the study.Raloxifen in doses of 60 mg/every other day or identical placebo were given over 16 weeks of follows up.Improved recovery for treatment group was assessed by measurment of Stanford Health Assessment Questionnaire (HAQ); Iranian version of hospital anxiety and depression questionnaire (IHAD); sleep disturbance; number of tender points; reduction of pain and fatigue based on visual analogue score. Results: Raloxifen produced a significantly higher response rate than placebo in treating fibromyalgia, in improving pain and fatigue symptoms, reduction in the number of tender points, sleep disturbance and recovery of activities in daily living as measured by the Stanford Health Assessment Questionnaire (HAQ). The mean age of Raloxifen group was lower than placebo group but the mean duration of disease and menopause was not significantly different between them so it doesn’t seem that the difference of age can explain the better effect of Raloxifen in this study.There was no effect of Raloxifen on HAD score among fibromyalgia patients. Conclusions: Given the doses of medication used in this study, Raloxifen was superior to placebo in the treatment of menopausal patients with fibromyalgia. Keywords: Fibromyalgia, Raloxifen, Menopause.

411 QUALITY OF LIFE AMONG CHILEAN MIDDLE AGED MEN A. Salazar, T. Paravic. University of Concepción, Nursing, Concepción, Chile Objective: To know the associated factors with quality of life in men during their andropause period. Methods: Quantitative, descriptive and correlational design. A studied population was composed of 49 men, among 40-65 year old who were members of a Heath Center located in Concepcion, Chile. Those people were assessed (tested) using a questionnaire created by the authors and Aging Males’ Symptoms Scale (Heinemann et al., 1999). In order to process the data, descriptive and interferential statistics were used. Values of p<0,05 were considered to be statistics significance. Results: The age average was 53,2 (DE= 8). 45,2% of tested men did not show any alteration in their quality of life, while 35,7% suffered a slight alteration. Predictable facts which explain the 38% of the variance in the quality of life during this period were age, use of medicine and perception men have about their partners’ psychological symptoms that appear in climacteric period. Conclusions: There is an important percentage of men who suffer alterations in their quality of life and has relation to described predictable factors. Therefore, it is necessary to develop effective intervention programs to provide health care services for them. Keywords: Aging males’ Symptoms, Quality of Life, Male Climacteric.

412 QUALITY OF LIFE RELATED TO COUPLES’ HEALTH DURING MALE AND FEMALE CLIMACTERIC PERIODS A. Salazar, T. Paravic. University of Concepción, Nursing, Concepción, Chile Objective: To know the quality of life related to couples’ health during male and female climacteric periods. Methods: Studied population was composed of 49 couples, formed by age range 40-60 years in women and 40-65 years in men who were members of a Health Center located in Concepcion, Chile. Women were assessed using the Specific Menopause Quality of Life Questionnaire and for men Aging Males’ Symptoms Scale was used. Descriptive statistics was used. Results: Age average was 50,7 and 53,2 for women and men respectively. Most of tested women showed a slight alteration in their quality of life, having more deterioration in physical and sexual domain. Most frequent manifestations in women were: depression, muscular and articular pain and physical tiredness. Almost half of men did not suffer any alteration in quality of life, while more than the 35,7% showed a slight alteration. Most frequent manifestations in men were: physical exhaustion in somatic area and muscular strength decrease and sexual performance decrease. Conclusion: Alteration in quality of life is presented in men and women at this period. Future analysis will permit to know associated variables. Keywords: Menopause-specific Quality of Life, Aging Male’s Symptoms Climacteric Scale, Andropause, Quality of Life.

413 PHYSICAL ACTIVITY AND RELATED FACTORS AMONG POST MENOPAUSAL WOMEN N. Sarafraz, A. Bagheri, F. Abbaszadeh, M. Kafaie. Kashan University of Medical Science, Kashan-Isfahan, Iran, Islamic Republic of Objectives: The purpose of this study was to examine physical activity among the elderly women with Barthel Index (BI)that has been recommended for the functional assessment of older people. Methods: The sample was obtained every women from the entire nursing home population (n = 190) in the city of Kashan, in 2008. Information was eventually collected by interview from persons and nurses. Activity was assessed using the Barthel Index (BI) test. Data analysis was performed with SPSS. Results: The results indicated the following: The More than 30% of the women reported decreased physical activity during their stay in the nursing home. Barthel Index score was>75 in 15%, 51-75 in 24% and <50 in 61% of women. Age, total number of medical conditions, and presence of cardiovascular were significant with low Barthel Index score (p<0.001). Conclusions: The results suggest that living conditions and factors related to health and functional capacity affect the level of physical activity among nursing home residents. In order to encourage this population to be physically active, attention should be paid not only to physical exercise but also to associated factors, such as satisfaction with everyday life and health. Keywords: Barthel Index, physical activity, elderly women.

414 THE RELATION OF PERSONAL AND SOCIAL FACTORS WITH PATTERNS AND SYMPTOMS OF MENOPAUSE M. Sayyah Melli 1 , M. Alizadeh 2 , H. Ebrahimi Bakhtavar 2 . 1 Tabriz University (Medical Sciences), Ob & Gyn, Tabriz, Iran, Islamic Republic of; 2 Tabriz University (Medical Sciences), Comunity Medicine, Tabriz, Iran, Islamic Republic of Objectives: To determine a relation between personal, social and reproductive factors with the frequency of mental and physical symptoms of menopause, quality of life, and women’s attitude toward menopause, a cross-sectional study was carried out. Methods: In this study, which conducted in the Clinics and Health Centers of Tabriz, Iran from April 2005 to April 2006. Three hundred women aged 40-60, filled a questionnaire about background details, history of pregnancy, mental and physical symptoms of menopause and women’s attitude toward menopause.