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Rare cause of airway obstruction in neonate
Free Papers—Poster Presentations no permanent facial nerve dysfunction. Aesthetic results were very extremely satisfactory. Conclusion: The aesthetic incision for parotidectomy provides the surgeon the opportunity to perform the surgery safely with an optimal cosmetic scar, thus improving patient satisfaction. doi:10.1016/j.ijom.2009.03.532
P60 Application of pedicle flap transfer for head and neck functional reconstruction G.Y. Zheng ∗ , D.P. Ren, X.D. Qiu, L.B. Sun Department of Oral and Maxillofacial Surgery, Mianyang Stomatological Hospital, China
Background and Objectives: To assess the results of different pedicle flaps in functional reconstruction of oral and maxillofacial defects. Methods: 32 patients with 36 flaps treated between 2001 and 2008 with pedicle flaps were involved in this retrospective study. Pedicle flaps included forehead skin flap, sternocleidomastoid myocutaneous flap, pectoralis major myocutaneous flap, submental island flap, subhyoid myocutaneous flap and thoracoacromial flap, etc. These flaps were used to reconstruct the defects of the tongue, palate, cheek, floor of mouth, fossa orbitalis, maxilla and mandible. Results: After 3 to 12 months follow-up, the flaps survived with primary healing with good appearance and function. One pectoralis major myocutaneous flap had partial necrosis. Conclusions: Pedicle flap transfer has the features of easy obtaining and high survival rate. It is an ideal material for repairing oral and maxillofacial region defects. doi:10.1016/j.ijom.2009.03.533
P61 Rare cause of airway obstruction in neonate M.Y.S. Chong 1,∗ , Z.A. Rahman 1 , D. Ganesan 2 , V. Waran 2 1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia 2 Division of Neurosurgery, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
Encephalocele is an uncommon congenital malformation with involvement of the central nervous system structures
characterised by tissues that herniates through skull defect. Herniation of encephaloceles can cause various problems and may be undiagnosed in some cases. This poster illustrates a case of sphenoid meningoencephalocele herniating through the anterior skull defect into the median cleft palate, presenting as a cystic lesion intraorally obstructing the airway. The patient also at the same time presented with various features suggestive of median cleft face syndrome or frontonasal dysplasia. doi:10.1016/j.ijom.2009.03.534
P62 Role of the decoy bone morphogenetic protein receptor in craniofacial morphogenesis M. Lu ∗ , F. Ping, J. Hong Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA, United States
Background and Objectives: Cleft lip with or without cleft palate is a frequent birth defect in humans requiring several surgery and extensive dental treatment. The genetic and molecular causes of cleft lip and palate are poorly understood. Recently studies shown that the epithelial and mesenchymal signals, such as bone morphogenetic protein (BMP), are important for outgrowth and the epithelial changes prior to lip fusion. This study is focused on a recently discovered decoy receptor for BMPs, BAMBI (BMP and activin membrane-bound inhibitor) that is expressed in the fusing areas of the lip. The goal is to over-express the BAMBI virus in the developing chicken face in order to study the effect on craniofacial morphogenesis. Methods: Xenopus construct of full-length BAMBI was cloned in frame into a shuttle vector, and finally into a retrovirus using the RACS system. The virus, RACS with BMABI and the control virus, RACS with green fluorescent protein (GFP) were grown up and ready for injection. Fertilised white leghorn eggs were incubated to the appropriate stage. The viral particles were microinjected into stage 15 check embryo face. Craniofacial morphogenesis was examined at stage 38. Results: There was clear deceased upper beak outgrowth in the group with microinjection of virus containing BAMBI. No abnormalities in the control group with virus containing GFP, which illustrated the viral infection itself does not affect development.
549
Conclusion: The phenotypes in RACSBAMBI were due to a failure of outgrowth of the facial prominences secondary to abnormal BMP signal. Further investigation is needed to identify the novel role for the decoy BMP receptor BAMBI in the lip fusion and novel interactions with other signals found in the fusing primary palate. doi:10.1016/j.ijom.2009.03.535
P63 Management of cleft lip and plate in ectrodactyly-ectodermal dysplasia-clefting syndrome K. Turkoglu ∗ , N. Tuncer, K. Orhan Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey
Introduction: Cleft lip and palate is closely associated with different embryological, functional and genetic entities. It may be an isolated anomaly or a part of a syndrome. It is important to differentiate syndromic or non-syndromic forms for following up of the patient. Case Report: A male newborn infant, admitted to our department with cleft lip and palate. Physical examination and radiological findings showed us the presence of cleft lip, palate. Further examinations revealed ectrodactyly, thin hair and precardial deviation with p63 gene anomaly. This findings correlate with ectrodactylyectodermal dysplasia-clefting (EEC) syndrome. The patient treated with surgery with a prosthetic rehabilitation appliance to overcome his feeding and aesthetic problems. Conclusion: The clinical features of the EEC syndrome with management issues of the cleft lip and are discussed and stress the capability of the combined therapies. doi:10.1016/j.ijom.2009.03.536
P64 Orthopaedic and surgical approach of a late-stage severe complete bilateral cleft lip and palate patient—a rare condition E. C ¸ imen ∗ , A.M. Tüzüner-Öncül, F. Atıl, U. Öz, M. Cambazo˘glu Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey
Cleft Lip Palate is the most common congenital craniofacial deformity, affecting about one baby out of every 700
P60 Application of pedicle flap transfer for head and neck functional reconstruction G.Y. Zheng ∗ , D.P. Ren, X.D. Qiu, L.B. Sun Department of Oral and Maxillofacial Surgery, Mianyang Stomatological Hospital, China
Background and Objectives: To assess the results of different pedicle flaps in functional reconstruction of oral and maxillofacial defects. Methods: 32 patients with 36 flaps treated between 2001 and 2008 with pedicle flaps were involved in this retrospective study. Pedicle flaps included forehead skin flap, sternocleidomastoid myocutaneous flap, pectoralis major myocutaneous flap, submental island flap, subhyoid myocutaneous flap and thoracoacromial flap, etc. These flaps were used to reconstruct the defects of the tongue, palate, cheek, floor of mouth, fossa orbitalis, maxilla and mandible. Results: After 3 to 12 months follow-up, the flaps survived with primary healing with good appearance and function. One pectoralis major myocutaneous flap had partial necrosis. Conclusions: Pedicle flap transfer has the features of easy obtaining and high survival rate. It is an ideal material for repairing oral and maxillofacial region defects. doi:10.1016/j.ijom.2009.03.533
P61 Rare cause of airway obstruction in neonate M.Y.S. Chong 1,∗ , Z.A. Rahman 1 , D. Ganesan 2 , V. Waran 2 1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia 2 Division of Neurosurgery, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
Encephalocele is an uncommon congenital malformation with involvement of the central nervous system structures
characterised by tissues that herniates through skull defect. Herniation of encephaloceles can cause various problems and may be undiagnosed in some cases. This poster illustrates a case of sphenoid meningoencephalocele herniating through the anterior skull defect into the median cleft palate, presenting as a cystic lesion intraorally obstructing the airway. The patient also at the same time presented with various features suggestive of median cleft face syndrome or frontonasal dysplasia. doi:10.1016/j.ijom.2009.03.534
P62 Role of the decoy bone morphogenetic protein receptor in craniofacial morphogenesis M. Lu ∗ , F. Ping, J. Hong Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA, United States
Background and Objectives: Cleft lip with or without cleft palate is a frequent birth defect in humans requiring several surgery and extensive dental treatment. The genetic and molecular causes of cleft lip and palate are poorly understood. Recently studies shown that the epithelial and mesenchymal signals, such as bone morphogenetic protein (BMP), are important for outgrowth and the epithelial changes prior to lip fusion. This study is focused on a recently discovered decoy receptor for BMPs, BAMBI (BMP and activin membrane-bound inhibitor) that is expressed in the fusing areas of the lip. The goal is to over-express the BAMBI virus in the developing chicken face in order to study the effect on craniofacial morphogenesis. Methods: Xenopus construct of full-length BAMBI was cloned in frame into a shuttle vector, and finally into a retrovirus using the RACS system. The virus, RACS with BMABI and the control virus, RACS with green fluorescent protein (GFP) were grown up and ready for injection. Fertilised white leghorn eggs were incubated to the appropriate stage. The viral particles were microinjected into stage 15 check embryo face. Craniofacial morphogenesis was examined at stage 38. Results: There was clear deceased upper beak outgrowth in the group with microinjection of virus containing BAMBI. No abnormalities in the control group with virus containing GFP, which illustrated the viral infection itself does not affect development.
549
Conclusion: The phenotypes in RACSBAMBI were due to a failure of outgrowth of the facial prominences secondary to abnormal BMP signal. Further investigation is needed to identify the novel role for the decoy BMP receptor BAMBI in the lip fusion and novel interactions with other signals found in the fusing primary palate. doi:10.1016/j.ijom.2009.03.535
P63 Management of cleft lip and plate in ectrodactyly-ectodermal dysplasia-clefting syndrome K. Turkoglu ∗ , N. Tuncer, K. Orhan Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey
Introduction: Cleft lip and palate is closely associated with different embryological, functional and genetic entities. It may be an isolated anomaly or a part of a syndrome. It is important to differentiate syndromic or non-syndromic forms for following up of the patient. Case Report: A male newborn infant, admitted to our department with cleft lip and palate. Physical examination and radiological findings showed us the presence of cleft lip, palate. Further examinations revealed ectrodactyly, thin hair and precardial deviation with p63 gene anomaly. This findings correlate with ectrodactylyectodermal dysplasia-clefting (EEC) syndrome. The patient treated with surgery with a prosthetic rehabilitation appliance to overcome his feeding and aesthetic problems. Conclusion: The clinical features of the EEC syndrome with management issues of the cleft lip and are discussed and stress the capability of the combined therapies. doi:10.1016/j.ijom.2009.03.536
P64 Orthopaedic and surgical approach of a late-stage severe complete bilateral cleft lip and palate patient—a rare condition E. C ¸ imen ∗ , A.M. Tüzüner-Öncül, F. Atıl, U. Öz, M. Cambazo˘glu Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey
Cleft Lip Palate is the most common congenital craniofacial deformity, affecting about one baby out of every 700