Selective toxicity. By Adrien Albert. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. x + 233 pp. 14 × 21.5 cm

Selective toxicity. By Adrien Albert. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. x + 233 pp. 14 × 21.5 cm

Book Notices General Chemistry-Inorganic and Organic. By GARTHL. LEE and HARRIS0. VANORDEN. w . B. Saunders Co., West Washington Square, Philadelphia ...

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Book Notices General Chemistry-Inorganic and Organic. By GARTHL. LEE and HARRIS0. VANORDEN. w . B. Saunders Co., West Washington Square, Philadelphia 5, Pa., 1960. vi 637 pp. 15.5 X 23.5 cm. Price $7.25. This book covers a wide field in simple, concise, positive statements. It could be useful as a textbook in the general science course. The author might have omitted the use of 2 stacked nickels to represent 1 cubic centimeter in the illustration of volume apparatus. It might be difficult for a chemistry minor t o grasp the full text, but if he learned to use the book as a starting reference it could be stimulating. A good index is appended and the 1958 revision of atomic weights is included.

Einfache Versuche auf dem Gebiete der organischen Chemie. 8th ed. By A. F. HOLLEMANand LEONHARDSCHULER. Walter de Gruyter & Co., Genthner Strasse 13, Berlin W 35, Germany, 1960. xx 172 pp. 14 X 22 cm. Paperbound. This book is a teaching text (in German) of simple and basic chemical reactions of organic compounds and their functional groups.

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Metal-Binding in Medicine. Edited by MARVINJ. SEVENand L. AUDREYJOHNSON. J. B. Lippincott Co., East Washington Square, Philadelphia 5, Pa., 1960. xiii 400 pp. 18 X 25.5 cm. Price $13.75. This book includes the papers and panel discussions from a symposium held May 6-8, 1959, in Philadelphia. The term “metal-binding” is used t o indicate linkage between a binding agent and a metal, with “chelation” being reserved for the process of metal-binding in which the metal is incorporated into a ring structure. The material covers a wide field, starting with “The Relationship of Chemical Structure to Metal-Binding Action” and including pharmacological, physiological, clinical, and therapeutic considerations of natural and induced metal-binding forms in normal and pathologic systems. An index is appended.

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Analytische Trennung und Identijtzierung organischer Substanzen. By OTTO NEUNHOEPFER. Walter de Gruyter & Co., Genthner Strasse 13, Berlin W 35, Germany, 1960. xii 116 pp. 17.5 X 23.5 cm. Price DM 18. This book (in German) covers concisely the methods for analytical separation and identification o f organic substances as applied in a teaching laboratory.

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Synthetic Methods of Organic Chemistry. Yol. 14. By W. THEILHEIMER. Interscience Putlishers, Inc., 250 Fifth Ave., New York 1, N. Y., 1960. xvi 549 pp. 15 X 23 cm. Price $29.50. Most of the references in Vol. 14 of this compilation of new methods for the synthesis of organic compounds and improvements of known methods cover papers published between 1957 and 1959. A comprehensive and concise reference series.

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A n Introduction to the Chemistry of Heterocyclic Compounds. By R. M. ACHESON. Interscience Publishers, Inc., 250 Fifth Ave., New York 1, N. Y., 1960. xiv -I- 342 pp. 15 X 23 cm. Price $5. This book attempts t o present to the undergraduare student a concise account of the more important properties and chemical reactions oI the basic heterocyclic systems. It is admittedly incomplete, omitting sugars and alkaloids, which the author assumes have been covered in other courses. Included are pertinent physical data, electronic and mechanistic concepts where possible, and brief discussions of chemical discoveries concerning metabolism and biosynthesis of some important compounds. Compound and subject indexes are appended.

Lehrburh der organischen Chemie. 35-36 ed. Edited by A. F. HOLLEMAN and FRIEDRICH RICHTER. Walter de Gruyter & Co., Genthner Strasse 13, Berlin W 35, Germany, 1960. xii 646 pp. 17 X 24 cm. Price DM 28. This classic textbook (in German) has been revised and edited again by Friedrich Richter who has performed this task for at least 30 years. Its reference value has been long established in the U. S. and elsewhere.

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Methods in Medical Research. Vol. 8. Edited by H. D. BRUNER. The Year Book Publishers, Inc., 200 East Illinois St., Chicago, Ill., 1960. xiv 368 pp. 13.5 X 21.5 cm. Price $9.75. The subjects considered in the eighth volume of this series are grouped under the main headings: Life history of the erythrocyte, Measurement of responses of involuntary muscle, and Peripheral blood flow measurement. Subject and name indexes arc appended.

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Selective Toxicity. By ADRIEN ALBERT. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. x 233 pp. 14 X 21.5 cm. Beginning with a discussion of the biochemical differences between species which introduce the possibility of selectivity into toxicity, four introductory paragraphs of this text are designed for undergraduate students in biochemistry, medicine, pharmacy, and agriculture. Nine other chapters take up advanced material related to biologically-active substances, including absorption and distribution, pharmacodynamics, covalency, surface chemistry, and steric factors. Appendix 1 is a tabulation showing the connection between ionization and antibacterial activity in the acridine series (101 compounds). Appendix 2 tabulates calculated percentage ionized, given pKa and pH (if anion or cation). Appendix 3 lists physical effects cf organic substituents.

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