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The salicylates. By Martin Gross and Leon A. Greenberg. Hillhouse Press, New Haven, 1948. xvii + 380 pp. 15 × 23.5 cm. Price $6.00
SCIENTIFIC EDITION
57
TABLE I.-RESULTS OF ASSAYOF PHENOBARBITAL preparations. It illustrates the adaptability of this COMPOUNDED IN VARIOUS MEDICINAL COMBINA- method t o control laboratory procedure. TIONS
Active Ingredients in Tablets
Atropine sulfate and phenobarbital Mannitol hexanitrate and phenobarbital Extract of stramonium and phenobarbital Extract of hyoscyamus and phenobarbital Hexestrol and phenobarbital Atropine sulfate, magnesium trisilicate, and phenobarbital Aluminum hydroxide, kaolin, homatropine, methylbromide, and phenobarbital
SUMMARY
Theoretical Amount of Phenobarbital per Tablet,
Colori-
0.25
0.250
0.25
0.250
0.25
0.247
0.25 0.25
0.254 0.257
0.125
0.128
0.167
0.166
Gr.
metric Assay,
Gr.
The Salicylates. B y MARTINGROSSand LEON A. GREENBERG.Hillhouse Press, New Haven, 1948. xvii 4- 380 pp. 15 x 23.5 cm. Price
$6.00. The Salicylates is the second of a series of monographs published under the auspices of the Institute for the Study of Analgesic and Sedative Drugs. The Institute is t o be congratulated upon the issuance of this monograph which is a genuine contribution t o the pharmacological and medical literature. The listing of 4093 references gives some evidence of the thoroughness of the task. Because of the use of salicylates in relatively large doses in rheumatic fever during recent years i t is particularly pertinent that such a monograph be assembled. After a short historical introduction the authors discuss the physical and chemical properties of the chief salicylates used in medicine. The properties of 39 salicylates are here tabulated. An extensive chapter on the fate of salicylates in the body then follows. This is one of the most significant chapters in the book and it is aided by the use of graphs selected from the best research papers in the literature. The material from this chapter forms the basis for the present consideration of salicylate dosage. Chapters on the pharmacology and toxicology and therapeutic uses of salicylates then follow. Full discussions on methods of measuring analgesic and antipyretic action, side effects, lethal doses, etc., are t o be found here. A chapter of nearly 40 pages on salicylate poisoning is of considerable interest. The basic data are taken from Census Bureau reports and the data are tabulated many ways. T o physicians the brief abstract of all 144 cases of poisoning recorded in the literature will be helpful. Each case is recorded
A colorimetric method for the determination of barbiturates in pharmaceutical preparations is described. Extracted residues containing barbiturates are dissolved i n an anhydrous solvent and reacted with cobaltous acetate in anhydrous isopropylamine solutions t o form color complexes. REFERENCES (1) Dille, J. M., and Koppanyi. T . , THISJOURNAL, 23,1079
(~-”--,. lQR41
(2) Linegar. C. R., Dille, J. M., and Koppanyi, T., ibid., 24, 847(1935). (3) Green, M.W.,Vietch, F. P., and Koppanyi, T., i b i d . , 32,309(1943). (4) Cohen. E. L.. Am. J . Pharm., 118, 40(1946).
along with the date and pertinent facts. Also recorded are 14 questionable cases. The bibliographic author index and the carefully prepared subject index combine to make this book a “must” for pharmaceutical libraries.
Repetitorium aus der Allgemeinen und Anorganischen Chemie j f i r Mediziner. By A. SIROTENKO. Akademischer Verlag der Auslandischen Wissenschaftler, Munich. xii 315 pp. 14 x 20.5.cm. This is a brief recapitulation of general and inorganic chemistry written in German for physicians. In addition t o the usual statements concerning occurrence, preparation, and properties of inorganic substances, a brief statement of medical use is appended.
+
Richter’s Organic Chemistry, Volume I V . By F. REINDELand L. ANSCH~~TZ. Translated by M. F. DARKENand A. J. MEE. Elsevier Publishing Company, New York, 1947. xv 498 pp. 13.5x 21.5 cm. Price $12.50. Volume IV of Richter, which is concerned with heterdcyclic compounds and free radicals, follows the general pattern of other volumes. (For a review of Volume 111 see THISJOURNAL, 35, 351. 1946.) Compounds covered are furans, thiophenes, pyrroles, indoles, azoles, pyrazoles, triazoles, oxadiazoles, pyrans, pyridines, oxazines, plant alkaloids and countless other heterocycles. The reader will find recorded here the basic chemistry of these heterocycles and free radicals, but he will not find a catalogue of the many hundreds of heterocycles developed during recent years, especially in the United States, for possible use as drugs.
+
57
TABLE I.-RESULTS OF ASSAYOF PHENOBARBITAL preparations. It illustrates the adaptability of this COMPOUNDED IN VARIOUS MEDICINAL COMBINA- method t o control laboratory procedure. TIONS
Active Ingredients in Tablets
Atropine sulfate and phenobarbital Mannitol hexanitrate and phenobarbital Extract of stramonium and phenobarbital Extract of hyoscyamus and phenobarbital Hexestrol and phenobarbital Atropine sulfate, magnesium trisilicate, and phenobarbital Aluminum hydroxide, kaolin, homatropine, methylbromide, and phenobarbital
SUMMARY
Theoretical Amount of Phenobarbital per Tablet,
Colori-
0.25
0.250
0.25
0.250
0.25
0.247
0.25 0.25
0.254 0.257
0.125
0.128
0.167
0.166
Gr.
metric Assay,
Gr.
The Salicylates. B y MARTINGROSSand LEON A. GREENBERG.Hillhouse Press, New Haven, 1948. xvii 4- 380 pp. 15 x 23.5 cm. Price
$6.00. The Salicylates is the second of a series of monographs published under the auspices of the Institute for the Study of Analgesic and Sedative Drugs. The Institute is t o be congratulated upon the issuance of this monograph which is a genuine contribution t o the pharmacological and medical literature. The listing of 4093 references gives some evidence of the thoroughness of the task. Because of the use of salicylates in relatively large doses in rheumatic fever during recent years i t is particularly pertinent that such a monograph be assembled. After a short historical introduction the authors discuss the physical and chemical properties of the chief salicylates used in medicine. The properties of 39 salicylates are here tabulated. An extensive chapter on the fate of salicylates in the body then follows. This is one of the most significant chapters in the book and it is aided by the use of graphs selected from the best research papers in the literature. The material from this chapter forms the basis for the present consideration of salicylate dosage. Chapters on the pharmacology and toxicology and therapeutic uses of salicylates then follow. Full discussions on methods of measuring analgesic and antipyretic action, side effects, lethal doses, etc., are t o be found here. A chapter of nearly 40 pages on salicylate poisoning is of considerable interest. The basic data are taken from Census Bureau reports and the data are tabulated many ways. T o physicians the brief abstract of all 144 cases of poisoning recorded in the literature will be helpful. Each case is recorded
A colorimetric method for the determination of barbiturates in pharmaceutical preparations is described. Extracted residues containing barbiturates are dissolved i n an anhydrous solvent and reacted with cobaltous acetate in anhydrous isopropylamine solutions t o form color complexes. REFERENCES (1) Dille, J. M., and Koppanyi. T . , THISJOURNAL, 23,1079
(~-”--,. lQR41
(2) Linegar. C. R., Dille, J. M., and Koppanyi, T., ibid., 24, 847(1935). (3) Green, M.W.,Vietch, F. P., and Koppanyi, T., i b i d . , 32,309(1943). (4) Cohen. E. L.. Am. J . Pharm., 118, 40(1946).
along with the date and pertinent facts. Also recorded are 14 questionable cases. The bibliographic author index and the carefully prepared subject index combine to make this book a “must” for pharmaceutical libraries.
Repetitorium aus der Allgemeinen und Anorganischen Chemie j f i r Mediziner. By A. SIROTENKO. Akademischer Verlag der Auslandischen Wissenschaftler, Munich. xii 315 pp. 14 x 20.5.cm. This is a brief recapitulation of general and inorganic chemistry written in German for physicians. In addition t o the usual statements concerning occurrence, preparation, and properties of inorganic substances, a brief statement of medical use is appended.
+
Richter’s Organic Chemistry, Volume I V . By F. REINDELand L. ANSCH~~TZ. Translated by M. F. DARKENand A. J. MEE. Elsevier Publishing Company, New York, 1947. xv 498 pp. 13.5x 21.5 cm. Price $12.50. Volume IV of Richter, which is concerned with heterdcyclic compounds and free radicals, follows the general pattern of other volumes. (For a review of Volume 111 see THISJOURNAL, 35, 351. 1946.) Compounds covered are furans, thiophenes, pyrroles, indoles, azoles, pyrazoles, triazoles, oxadiazoles, pyrans, pyridines, oxazines, plant alkaloids and countless other heterocycles. The reader will find recorded here the basic chemistry of these heterocycles and free radicals, but he will not find a catalogue of the many hundreds of heterocycles developed during recent years, especially in the United States, for possible use as drugs.
+