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Thiophene and Its Derivatives. By Howard D. Hartough. Interscience Publishers, Inc., New York, 1952. xvii + 533 pp. 16 × 23.5 cm. Subscription price $15; list price $16.50
Book Reviews
Thiophene and Its Derivatives. By HOWARDD. HARTOUGH.Interscience Publishers, Iric., New York, 1952. xvii 533 pp. 16 x 23.5 cm. Subscription price $15; list price $16.50. This is the third volume to appear of a series of monographs devoted to a modern detailed and comprehensive presentation of heterocyclic chemistry by a group of authorities. The subdivisions have been designed t o cover the field in its entirety by monographs which reflect the importance and the interrelations of the various compounds. This treatise, according to the author, was designed to cover critically all phases of thiophene chemistry and to point out some of the existing problems yet to be solved. Even a casual examination of Dr Hartough’s book will indicate to the reader that the author’s aim in writing it has beean eminently successful. The book is of special interest to research workers in organic pharmaceutical chemistry because of the use of thiophene derivatives as intermediates in the synthesis of certain antihistaminic drugs, and the possibility of using them for the development of other new drugs in addition to the antihistaminics. The biological and pharmacological activity of thiophene and its derivatives is adequately reviewed in a chapter contributed by Professor F. F. Blicke of the College of Pharmacy of the University of Michigan. The scope of the book can best be visualized from an examination of the chapter titles, which are: General Discussion ; Biological and Pharmacological Activity of Thiophene and Its Dcrivatives; Synthesis and Physical Properties of Thiophene and I t s Homologs; Molecular Structure and Spectroscopy of Thiophene and Its Derivatives; Factors Affecting Substitution Reactions in the Thiophene Nucleus; Alkylation. Polymerization, Hydrogenation and Miscellaneous Reactions of Thiophene ; Halothiophenes and Haloalkylthiophenes; The Nitro- and Aminothiophenes ; Thiophene Compounds Containing Nitrogen in the Side Chain; Hydroxythiophenes, Thienylalkanols, Alkoxythiophenes, and Thienylalkyl Ethers; Aldo and Keto Derivatives of Thiophene; Carboxy Derivatives of Thiophene; Sulfur Derivatives of Thiopbene; Metal and Miscellaneous Mefalloid Derivatives of Thiophene; Synthesis and Properties of Di- and Polythienyls and Arylthiophenes ; and Selenophene, Tetrahydroselenophene, Tellurophene, and Tetrahydrotellurophene. Since the discovery of thiophene in 1882, by Victor Meyer, many publications concerning it and its derivatives have appeared. The most active period of research in the field of thiophene chemistry, however, has been since 1945, when it first became commercially available. As an example of the recent acceleration of research during this period, the author points out that since October 1, 1949. when the manuscript for the text was completed, about 400 additional articles and patents
+
have been published.
Thiophcne and Its Dcriva-
lives should find wide appeal and create much in-
terest among research workers in organic chemistry, and particularly those interestcd in drugs, resins, or dyes. It is interesting to note that the main commercial use for thiophene derivatives at the present time is as intermediates in the production of antihistaminic drugs. It is predicted, however, that other commercial applications will develop rapidly in the future. The book is completely documented with references through October 1, 1949. Its value is enhanced by an adequate Dubjcct index, and an appendix in which established and tested preparative methods for thiophcne derivatives useful as intermediates are given. The format of the book is attractive, and the printing and binding are of excellent quality. The 1951 Year Book of Drug Therapy. Edited by HARRYBECKMAN.The Year Book Publishers, Inc., Chicago, 1951. 502 pp. Illustrated. 20 x 13 cm. Price $5. This book is composed of a series of abstracts of essentially significant articles dealing with drug therapy which were published between August, 1950, and September, 1951. No attempt is made to present an annotated bibliography on the various conditions and treatments discussed, but it appears that the most significant publications are covered. The references to the original articles cited will enable the reader to locate additional information if he so desires. While the book is mainly of interest to physicians, some pharmacists who are frcquently called upon for advice on recent developments in drug therapy will find the book useful as a ready reference. The value of the book is enhanced by an index to authors and an adequate sdbject index. The Physiological Foundution of Dental Practice. By L. L. LANGLEY and E. CHERASKIN.C. V. Mosby Company, St. Louis, Mo., 1951. 511 pp. Illustrated. 18 x 25.5 cm. Price $8.25. This relatively concise textbook on physiology has been designed to meet the special needs of dental students by specially emphasizing the parts of the subject of particular dental interest. For example, the physiology of the nervous system is first considered, and comprises about a third of the entire book. The authors explain that this is justified because the dentist is concerned more intimately with the nervous system than with any of the other systems. The book is clearly written, well illustrated, and suitably documented a t the end of each chapter with references to supplementary readings. It is quite possible that it could be used advantageously as a textbook for students in pharmacy or as a reference book for supplementary reading in that subject
338
Thiophene and Its Derivatives. By HOWARDD. HARTOUGH.Interscience Publishers, Iric., New York, 1952. xvii 533 pp. 16 x 23.5 cm. Subscription price $15; list price $16.50. This is the third volume to appear of a series of monographs devoted to a modern detailed and comprehensive presentation of heterocyclic chemistry by a group of authorities. The subdivisions have been designed t o cover the field in its entirety by monographs which reflect the importance and the interrelations of the various compounds. This treatise, according to the author, was designed to cover critically all phases of thiophene chemistry and to point out some of the existing problems yet to be solved. Even a casual examination of Dr Hartough’s book will indicate to the reader that the author’s aim in writing it has beean eminently successful. The book is of special interest to research workers in organic pharmaceutical chemistry because of the use of thiophene derivatives as intermediates in the synthesis of certain antihistaminic drugs, and the possibility of using them for the development of other new drugs in addition to the antihistaminics. The biological and pharmacological activity of thiophene and its derivatives is adequately reviewed in a chapter contributed by Professor F. F. Blicke of the College of Pharmacy of the University of Michigan. The scope of the book can best be visualized from an examination of the chapter titles, which are: General Discussion ; Biological and Pharmacological Activity of Thiophene and Its Dcrivatives; Synthesis and Physical Properties of Thiophene and I t s Homologs; Molecular Structure and Spectroscopy of Thiophene and Its Derivatives; Factors Affecting Substitution Reactions in the Thiophene Nucleus; Alkylation. Polymerization, Hydrogenation and Miscellaneous Reactions of Thiophene ; Halothiophenes and Haloalkylthiophenes; The Nitro- and Aminothiophenes ; Thiophene Compounds Containing Nitrogen in the Side Chain; Hydroxythiophenes, Thienylalkanols, Alkoxythiophenes, and Thienylalkyl Ethers; Aldo and Keto Derivatives of Thiophene; Carboxy Derivatives of Thiophene; Sulfur Derivatives of Thiopbene; Metal and Miscellaneous Mefalloid Derivatives of Thiophene; Synthesis and Properties of Di- and Polythienyls and Arylthiophenes ; and Selenophene, Tetrahydroselenophene, Tellurophene, and Tetrahydrotellurophene. Since the discovery of thiophene in 1882, by Victor Meyer, many publications concerning it and its derivatives have appeared. The most active period of research in the field of thiophene chemistry, however, has been since 1945, when it first became commercially available. As an example of the recent acceleration of research during this period, the author points out that since October 1, 1949. when the manuscript for the text was completed, about 400 additional articles and patents
+
have been published.
Thiophcne and Its Dcriva-
lives should find wide appeal and create much in-
terest among research workers in organic chemistry, and particularly those interestcd in drugs, resins, or dyes. It is interesting to note that the main commercial use for thiophene derivatives at the present time is as intermediates in the production of antihistaminic drugs. It is predicted, however, that other commercial applications will develop rapidly in the future. The book is completely documented with references through October 1, 1949. Its value is enhanced by an adequate Dubjcct index, and an appendix in which established and tested preparative methods for thiophcne derivatives useful as intermediates are given. The format of the book is attractive, and the printing and binding are of excellent quality. The 1951 Year Book of Drug Therapy. Edited by HARRYBECKMAN.The Year Book Publishers, Inc., Chicago, 1951. 502 pp. Illustrated. 20 x 13 cm. Price $5. This book is composed of a series of abstracts of essentially significant articles dealing with drug therapy which were published between August, 1950, and September, 1951. No attempt is made to present an annotated bibliography on the various conditions and treatments discussed, but it appears that the most significant publications are covered. The references to the original articles cited will enable the reader to locate additional information if he so desires. While the book is mainly of interest to physicians, some pharmacists who are frcquently called upon for advice on recent developments in drug therapy will find the book useful as a ready reference. The value of the book is enhanced by an index to authors and an adequate sdbject index. The Physiological Foundution of Dental Practice. By L. L. LANGLEY and E. CHERASKIN.C. V. Mosby Company, St. Louis, Mo., 1951. 511 pp. Illustrated. 18 x 25.5 cm. Price $8.25. This relatively concise textbook on physiology has been designed to meet the special needs of dental students by specially emphasizing the parts of the subject of particular dental interest. For example, the physiology of the nervous system is first considered, and comprises about a third of the entire book. The authors explain that this is justified because the dentist is concerned more intimately with the nervous system than with any of the other systems. The book is clearly written, well illustrated, and suitably documented a t the end of each chapter with references to supplementary readings. It is quite possible that it could be used advantageously as a textbook for students in pharmacy or as a reference book for supplementary reading in that subject
338