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Conclusions: ,QWKLVFRKRUWRISDWLHQWVRI)6FRXOGKDYHEHHQDYRLGDEOHRQ WKHVLWHRIWKHSURVWDWHZKHUH7&8QRUELRSV\FRUHVZHUHSRVLWLYHIRUFDQFHURXV WLVVXH7KHVHGDWDHQFRXUDJHIRUIXUWKHULQYHVWLJDWLRQ/LPLWDWLRQVRIWKLVVWXG\DUH DVPDOOVDPSOHVL]H7KHUHIRUHWKHXVHRI7&8IRUGHFLVLRQPDNLQJXSRQQHUYH VSDULQJSURFHGXUHFDQQRWEHPDGH\HW
104
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105
PCA3: A MULTICENTER EXPERIENCE FROM SOUTHERN ITALY
$XWRULQR5'DPLDQR5'H6LR03L]]XWL00XVFDULHOOR5 'H'RPHQLFR54XDUWR*$]]DULWR**DOOR/*DOOR$'ಬ$UPLHQWR0 'L/RUHQ]R*3HUGRQD6 1 Second University of Naples, Dept. of Urology, Naples, Italy, 2Magna Greacia University, Dept. of Urology, Catanzaro, Italy, 3Magna Graecia University, Dept. of Urology, Catanzaro, Italy, 4National Tumor Institute - G. Pascale Foundation, Dept. of Urology, Naples, Italy, 5Federico II University, Dept. of Oncology, Naples, Italy Introduction & Objectives: 8ULQDU\ SURVWDWH FDQFHU JHQH 3&$ KDV VKRZQ WR EH D SURPLVLQJ QRYHO PDUNHU RI SURVWDWH FDQFHU GHWHFWLRQ $LP RI WKH FXUUHQW VWXG\ ZDV WR HYDOXDWH WKH DELOLW\ RI 3&$ DGGHG WR PHDVXUHPHQWV RI VHUXP SURVWDWHVSHFLᚏF DQWLJHQ 36$ WR SUHGLFW FDQFHU GHWHFWLRQ LQ D VRXWKHUQ ,WDOLDQ SRSXODWLRQ Material & Methods: %HWZHHQ6HSWHPEHUWR-XO\ZKROHXULQHVDPSOHV ZHUHFROOHFWHGDIWHUDWWHQWLYHGLJLWDOUHFWDOH[DPLQDWLRQVIURPPHQEHIRUHWKH\ XQGHUZHQWXOWUDVRXQGJXLGHGFRUHSURVWDWHELRSV\LQRXWSDWLHQWFOLQLFLQWKUHH UHIHUUDOFHQWHUV,171DSROL6811DSROL80*&DWDQ]DUR 8ULQH3&$P51$ OHYHOVDIWHUGLJLWDOUHFWDOH[DPLQDWLRQZHUHGHWHUPLQHGXVLQJWUDQVFULSWLRQPHGLDWHG DPSOLᚏFDWLRQ7KHFXWRᚎIRUDSRVLWLYH3&$VFRUHZDVSUHHVWDEOLVKHGDW7KH 3&$UHVXOWVZHUHFRUUHODWHGZLWKWKHVHUXP36$OHYHOSUHYLRXVELRSV\KLVWRU\ DQGWKHSURVWDWHELRSV\ᚏQGLQJV Results: 2IWHVWHGSDWLHQWVKDGSUHYLRXVO\XQGHUJRQH!SURVWDWHELRSV\ KDGD36$OHYHO!QJP/7KH3&$WHVWLQIRUPDWLYHUDWHZDV7KH PHDQDQGPHGLDQ3&$VFRUHZDVDQGUHVSHFWLYHO\2ISDWLHQWVIRU ZKRPKLVWRU\ZDVDYDLODEOH KDGXQGHUJRQHSUHYLRXVSURVWDWHELRSVLHV 7KH ᚏQGLQJV RI WKH FRQFXUUHQW ELRSVLHV ZHUH DV IROORZV %3+ IRU SRVLWLYHIRU&D3IRU DQG$6$3+*3,1LQ 8VLQJWKHSUHGHᚏQHG FXWRᚎRIWKH3&$WHVWZDVQHJDWLYHLQRISDWLHQWVZLWK%3+EXWZDV SRVLWLYH LQ RI SDWLHQWV ZLWK SRVLWLYH FRQFXUUHQW ELRSV\ ᚏQGLQJV ([FOXGLQJ $6$3+*3,1FDVHVWKHVHQVLWLYLW\RI3&$IRU&D3RQELRSV\ZDVDQGWKH VSHFLᚏFLW\ZDV%\XVLQJUHFHLYHURSHUDWLQJFKDUDFWHULVWLFFXUYHDQDO\VLVD FRPELQHG 36$ DQG 3&$ VFRUH UHVXOWHG LQ DQ $8& RI ZKLFK ZDV KLJKHU WKDQ36$DORQH/LNHOLKRRGRISURVWDWHFDQFHUGHWHFWLRQURVHZLWKLQFUHDVLQJ3&$ VFRUHUDQJHV Conclusions: 8ULQH3&$WHVWLQJSHUIRUPHGZHOODVDODERUDWRU\GHYHORSHGWHVW ,WVKLJKVSHFLᚏFLW\RI3&$ZDVFRQᚏUPHGLQWKLVVWXG\SRSXODWLRQ,QSDWLHQWVZLWK HOHYDWHG36$OHYHOVDQGQHJDWLYHELRSV\ᚏQGLQJV3&$WHVWLQJPLJKWEHXVHIXOLQ IXUWKHUFOLQLFDODGYLFH
106
SHOULD WE CHANGE NUMBER OF SAMPLING CORES ACCORDING TO CLINICAL VARIABLES AT AN INITIAL PROSTATE BIOPSY?
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Eur Urol Suppl 2010;9(2):66
Introduction & Objectives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aterial & Methods: %HWZHHQ-XQHDQG6HSWHPEHUPHQZLWK SURVWDWHVSHFLᚏF DQWLJHQ 36$ OHVV WKDQ QJPO RU GLJLWDO UHFWDO H[DPLQDWLRQ '5( ᚏQGLQJVVXJJHVWLYHRIRUJDQFRQᚏQHGGLVHDVHXQGHUZHQWWKUHHGLPHQVLRQDO FRUH ELRSV\ '3%[ RU PRUH H[WHQGHG ELRSVLHV LQFOXGLQJ '3%[ DV DQ LQLWLDO ELRSV\ '3%[ LV D FRPELQDWLRQ RI WUDQVSHULQHDO FRUH ELRSV\ DQG WUDQVUHFWDOIDUODWHUDOFRUHELRSV\753%[ ,QWKLVDQDO\VLVZHXVHGWKHGDWD REWDLQHGIURP'3%[RU'3%[SDUWRIPRUHH[WHQGHGELRSVLHV:HIXUWKHU GHᚏQHG 753%[ SOXV IRXU SRVWHULRU VDPSOLQJV RI WUDQVSHULQHDO FRUH ELRSV\ DV '3%[DVXEVHWRI'3%[ 8VLQJWKHGDWDREWDLQHGIURP753%['3%[ DQG'3%[ZHHYDOXDWHGDEVROXWHLQFUHDVHLQFDQFHUGHWHFWLRQUDWHLQSDWLHQW VXEJURXSVGHᚏQHGE\36$SURVWDWHYROXPH39 RU'5(ᚏQGLQJVZKHQZHDGGHG IRXUFRUHVVDPSOLQJ36$DQG39ZHUHGLYLGHGLQWRTXDUWLOHV Results: &DQFHUGHWHFWLRQUDWHVRI753%['3%[DQG'3%[ZDV DQG UHVSHFWLYHO\ 7KH WDEOH GLVSOD\V FDQFHU GHWHFWLRQ UDWHV RI WKH ELRSV\ VFKHPHV DQG DEVROXWH LQFUHDVH LQ FDQFHU GHWHFWLRQ UDWHV DPRQJ WKH ELRSV\ VFKHPHVLQHDFKVXEJURXS7KHUHZHUHQRVLJQLᚏFDQWWUHQGVLQDEVROXWHLQFUHDVH LQ FDQFHU GHWHFWLRQ UDWHV LQ VXEJURXSV GHᚏQHG E\ 36$ 39 DQG '5( ᚏQGLQJV &RFKUDQ$UPLWDJH WUHQG WHVW ,W GLG QRW UHDFK VWDWLVWLFDO VLJQLᚏFDQFH DEVROXWH LQFUHDVHLQFDQFHUGHWHFWLRQUDWHVWHQGHGWREHKLJKHULQVPDOOHUSURVWDWHDQGLQ KLJKHU36$OHYHO753%[WR'3%[ &DQFHUGHWHFWLRQ UDWH
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107
PREOPERATIVE NOMOGRAMS FOR PREDICTING EXTRACAPSULAR EXTENSION IN RADICAL PROSTATECTOMY WITH LOCALIZED PROSTATE CANCER: A MULTI-INSTITUTIONAL CLINICOPATHOLOGIC STUDY
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108
TEMPLATE TRANSPERINEAL PROSTATE MAPPING BIOPSIES FOR PROSTATE CANCER RISK STRATIFICATION AND CANCER LOCALIZATION
6LQJK3%$KPHG+86WHYHQV'*XUXQJ3)UHHPDQ$(PEHUWRQ0 1 University College London, Dept. of Surgery and Interventional Sciences, London, United Kingdom, 2University College London Hospitals Nhs Trust, Dept. of Histopathology, London, United Kingdom Introduction & Objectives: 0HQZLWKDSURVWDWHFDQFHUGLDJQRVLVZKRDUHVXLWDEOH IRU DFWLYH VXUYHLOODQFH UHTXLUH DFFXUDWH ULVN VWUDWLᚏFDWLRQ 7HPSODWH WUDQVSHULQHDO SURVWDWHPDSSLQJ730 ELRSVLHVPD\VHUYHWKLVSXUSRVH Material & Methods: PHQXQGHUZHQWWHPSODWHELRSVLHVEHWZHHQDQG RIWKHVHPHQKDG730DVDFRQVHTXHQFHRIUHFODVVLᚏFDWLRQUHTXLUHPHQW LQ WKH FRQWH[W RI D SULRU QHJDWLYH 7586 ELRSV\ Q RU ORZLQWHUPHGLDWH ULVN SURVWDWH FDQFHU Q 730 ZHUH FRQGXFWHG WR D PP VDPSOLQJ IUDPH UHIHUHQFHG WR D JULG ZLWK DSLFDO DQG EDVDO QHHGOH GHSOR\PHQWV WR VDPSOH WKH = D[LV 7KH SURFHGXUH ZDV SHUIRUPHG LQ DQ DPEXODWRU\ FDUH VHWWLQJ XVLQJ HLWKHU UHJLRQDORUJHQHUDODQDHVWKHVLD Results: 0HDQDJHZDV\HDUVUDQJH\ DQGPHDQ36$QJPOUDQJH 1XPEHURIELRSV\FRUHVWDNHQDW7586DQGSURVWDWHPDSSLQJZDVPHDQ UDQJH DQGUDQJH UHVSHFWLYHO\6LGHHᚎHFWVDWWULEXWHGWR730 LQFOXGHGPLOGHFFK\PRVHVLQDOOSDWLHQWVXULQDU\UHWHQWLRQKDHPDWXULD UHTXLULQJDGPLVVLRQ1RHSLVRGHVRIVHSVLVZHUHUHFRUGHG*OHDVRQXSJUDGLQJRQ SURVWDWHPDSSLQJRFFXUUHGLQRIWKRVHZLWK*OHDVRQVFRUHFDQFHURQWKH RULJLQDO7586ELRSVLHV7ZRWKLUGVRIWKRVHZLWKXQLODWHUDOFDQFHURQ7586KDG ELODWHUDOGLVHDVHRQWHPSODWHPDSSLQJ Conclusions: 3URVWDWHPDSSLQJJLYHVSUHFLVHULVNVWUDWLᚏFDWLRQZLWKORZPRUELGLW\ 7KHVHRXWFRPHVKDYHLPSOLFDWLRQVIRUXVLQJGLDJQRVWLF7586ELRSV\WRGHFLGHRQ DFWLYH VXUYHLOODQFH RYHU DFWLYH WKHUDS\ $OWKRXJK WKH XSIURQW KHDOWKFDUH EXUGHQ DQGFRVWLVVLJQLᚏFDQWWKHJUHDWHUSUHFLVLRQPRUHDFFXUDWHULVNVWUDWLᚏFDWLRQDQG ZLWKWLPHPRUHDSSURSULDWHWUHDWPHQWDOORFDWLRQPD\LQGLFDWHWKDWWKHRYHUDOOFRVWV RILOOQHVVDUHUHGXFHG
109
VALUE OF REAL-TIME ELASTOGRAPHY TARGETED AND SYSTEMATIC TRANSRECTAL ULTRASOUND-GUIDED BIOPSY FOR PROSTATE CANCER DETECTION
9RLJW6*ULPP02:LUWK03 Technical University of Dresden, Dept. of Urology, Dresden, Germany Introduction & Objectives: :HSHUIRUPHGWKLVSURVSHFWLYHVWXG\WRVHHZKHWKHU FRPELQLQJUHDOWLPHHODVWRJUDSK\WDUJHWHGDQGV\VWHPDWLFWUDQVUHFWDOXOWUDVRXQG JXLGHG7586 ELRSV\FDQLPSURYHSURVWDWHFDQFHUGHWHFWLRQDQGWRDVVHVVWKH YDOXHRIHODVWRJUDSK\WDUJHWHGELRSV\DORQH Material & Methods: %HWZHHQ-XQHDQG0D\SDWLHQWVXQGHUZHQW 7586ELRSV\DQGHODVWRJUDSK\$OOH[DPLQDWLRQDQGELRSVLHVZHUHFDUULHGRXWZLWK WKH (%8+9 +LWDFKL PHGLFDO 7KH PHGLDQ QXPEHU RI V\VWHPDWLF ELRSVLHV ZDV 7KHPHGLDQQXPEHURIDGGLWLRQDOHODVWRJUDSK\WDUJHWHGELRSVLHV WDNHQIURPVXVSLFLRXVDUHDVZDV
Results: 0HDQ DJH ZDV \HDUV 0HDQ 36$ ZDV QJPO ,Q FDVHV ZH KDG VXVSLFLRXV ᚏQGLQJV LQ WKH GLJLWDO UHFWDO H[DPLQDWLRQ ,QFDVHVWKHUHZDVDWOHDVWRQHPHDQ SULRUELRSV\RIWKHSURVWDWH ,Q FDVHV SURVWDWH FDQFHU ZDV KLVWRORJLFDOO\ FRQᚏUPHG 7KHUHE\ FDQFHU ZDV IRXQGLQ RIWKHV\VWHPDWLFFRUHVDQGLQ RIWKH HODVWRJUDSK\ WDUJHWHG FRUHV &DQFHU ZDV GLDJQRVHG LQ FDVHV E\V\VWHPDWLFELRSV\ RQO\DQGLQ FDVHVE\HODVWRJUDSK\ WDUJHWHG ELRSV\RQO\,Q FDVHVFDQFHUZDVIRXQGSDUDOOHOLQELRSVLHVRIERWK PHWKRGVᚏJXUH Conclusions: &RPSDULQJ ERWK PHWKRGV WKHUH LV QR VWDWLVWLFDO GLᚎHUHQFH IRU SURVWDWHFDQFHUGHWHFWLRQ+RZHYHUPRVWRIWKHFDVHVZLWKSURVWDWHFDQFHUZHUH GHWHFWHGE\V\VWHPDWLFELRSV\$OWKRXJKZHGLDJQRVHGDGGLWLRQDOFDUFLQRPDVLW LVQRW\HWSRVVLEOHWRVWDWLVWLFDOO\GHPRQVWUDWHWKDWFRPELQLQJV\VWHPDWLF7586DQG HODVWRJUDSK\WDUJHWHGELRSV\FDQLPSURYHFDQFHUGHWHFWLRQ
110
TISSUE SAMPLING IS NOT ADEQUATE IN THE DETECTION OF PROSTATE CANCER IN TRANSITION ZONE
'RJDQ%6HUHIRJOX(&$WPDFD$)&DQGD$($NEXOXW=%DOED\0' Ankara Atatürk Training and Research Hospital, Dept. of 1st Urology, Ankara, Turkey Introduction & Objectives: 7RDVVHVVLIWUDQVLWLRQDO]RQHVDPSOLQJRIWKHSURVWDWH LVQHFHVVDU\GXULQJUHSHDWSURVWDWHELRSV\3%[ SURFHGXUHV Material & Methods: %HWZHHQ $SULO -XO\ SDWLHQWV ZKR XQGHUZHQW WUDQVXUHWKUDO UHVHFWLRQ RIWKHSURVWDWH 7853 DQG ZKR KDG SULRU QHJDWLYH 3%[ UHVXOWVZHUHUHWURVSHFWLYHO\HYDOXDWHG5HVXOWVRIKLVWRSDWKRORJLFDOHYDOXDWLRQVRI VXUJLFDOVSHFLPHQVDQGFDQFHUGHWHFWLRQUDWHVZHUHDVVHVVHG Results: $WRWDORISDWLHQWVXQGHUZHQW7853DQGKDGDWOHDVWQHJDWLYH3%[ 2YHUDOO ELRSV\ SURFHGXUHV ZHUH SHUIRUPHG KDG RQO\ RQH KDG WZR KDG WKUHH DQG KDG IRXU 3%[ 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV SHUIRUPHG LQ 3%[ SHUIRUPHG RQ SDWLHQWV DQG SURVWDWH FDQFHU 3&D ZDV GHWHFWHG LQ WKH VXUJLFDO VSHFLPHQ RI RQH SDWLHQW 7UDQVLWLRQDO ]RQH VDPSOLQJ ZDV QRW LQFOXGHGLQSURVWDWHELRSVLHVSHUIRUPHGRQSDWLHQWV DQG3&DZDVGHWHFWHG LQWKHVXUJLFDOVSHFLPHQRISDWLHQWV 0HDQSDWLHQWDJHZDV\HDUV PHDQ VHUXP SURVWDWH VSHFLᚏF DQWLJHQ 36$ ZDV QJP/ PHDQ SURVWDWH YROXPHZDVFF3DWKRORJ\UHVXOWVRIWKH3%[ZHUHDVIROORZVEHQLJQ LQᚐDPPDWLRQ KLJKJUDGH SURVWDWLF LQWUDHSLWKHOLDO QHRSODVLD +*3,1 3&D 3DWKRORJ\UHVXOWVRIWKH7853SURFHGXUHVZHUHDVIROORZV EHQLJQ LQᚐDPPDWLRQ +*3,1 3&D Conclusions: 6LQFH WKHUH ZDV QR VLJQLᚏFDQW GLᚎHUHQFH EHWZHHQ SDWLHQW JURXSV ZLWK RU ZLWKRXW WUDQVLWLRQDO ]RQH ELRSVLHV LQ GHWHFWLRQ RI 3&D LQ WUDQVLWLRQ ]RQH VWUDWHJLHVLQFOXGLQJLQFUHDVLQJQXPEHURIFDVHVWREHWDNHQIURPWUDQVLWLRQ]RQHRI WKHSURVWDWHVKRXOGEHFRQVLGHUHG
111
FRACTAL DIMENSION AS A NOVEL MEASURE OF PROSTATE CANCER GRADING
:DOLV]HZVNL3$EX(LG5.ULEXV66FKDIKDXVHU:6WHQ]O$ 1 St. Elisabeth Klinikum, Dept. of Urology, Straubing, Germany, 2University of Aberdeen, School of Dentistry, Aberdeen, United Kingdom, 3Pathology Office, Dept. of Pathology, Hof, Germany, 4Prostate Cancer Center, Dept. of Urology, Marktredwitz, Germany, 5Eberhard-Karls University of Tübingen, Dept. of Urology, Tübingen, Germany Introduction & Objectives: %RWKGLᚎHUHQWLDWLRQRISURVWDWHFDQFHUFHOOVDQGWKHLU RUJDQL]DWLRQ LQWR WLVVXH VWUXFWXUHV RI WKH KLJKHU RUGHU VXFK DV JODQGV LV VFRUHG DFFRUGLQJ WR WKH VXEMHFWLYH *OHDVRQ V\VWHP 7KHUH LV D QHHG IRU DQ REMHFWLYH PHDVXUHRIWXPRXUJUDGLQJ Material & Methods: 7RUHDFKWKDWJRDODVSDWLDOGLVWULEXWLRQRIDVHWRIQRUPDORU FDQFHUFHOOQXFOHLDVZHOODVVRPHJHRPHWULFDOIHDWXUHVRIVLQJOHFHOOVVXFKDVWKH DUHDSHULPHWHU GLPHQVLRQ WKHLU VSDWLDO IUDFWDO GLPHQVLRQ FHOO DUHD )HUHW DQJOH FHOO EUHDGWK FRQYH[LW\ DQG VSKHULFLW\ ZHUH LQYHVWLJDWHG LQ WKH WZR GLPHQVLRQDO WLVVXHVOLGHVVWDLQHGZLWKKDHPDWR[\OLQHRVLQDIWHUDSSO\LQJDFRORXUGHFRQYROXWLRQ DOJRULWKP'HᚏQLHQV7LVVXH0DSZDVXVHGIRUWKHDXWRPDWLFLGHQWLᚏFDWLRQRI FHOOQXFOHL)UDFWDODQDO\VLVZDVGRQHZLWK%HQRLWDQG,PDJH-T Results: $ JHRPHWULFDO REMHFW SRVVHVVHV IUDFWDO VWUXFWXUH LI WKHUH LV D OLQHDU UHODWLRQVKLS EHWZHHQ WKH ORJDULWKP RI D ER[ VL]H DQG WKH ORJDULWKP RI D QXPEHU RI WKH ER[HV FRYHULQJ WKDW REMHFW 6XFK WKH OLQHDU UHODWLRQVKLS ZDV IRXQG LQ DOO FDVHVDQDO\]HG7KHVSDWLDOIUDFWDOGLPHQVLRQIRUWKHQRUPDODSSHDULQJSURVWDWH WLVVXHLV Q IRUWKH*OHDVRQSDWWHUQ Q IRUWKH *OHDVRQSDWWHUQ Q DQGIRUWKH*OHDVRQSDWWHUQ Q ,QDGGLWLRQGLᚎHUHQWDUHDVRIWKHVDPHWXPRXUSRVVHVVHGDVLPLODUYDOXH RIWKHVSDWLDOIUDFWDOGLPHQVLRQ7KHUHLVQRVWDWLVWLFDOO\VLJQLᚏFDQWGLᚎHUHQFHLQWKH DUHDSHULPHWHU GLPHQVLRQ EHWZHHQ WKH QRUPDO FHOO QXFOHL DQG FDQFHU FHOO QXFOHL RI DOO *OHDVRQ SDWWHUQV VWXGLHG :LWK UHJDUGV WR WKH PRUSKRPHWULF FHOO DQDO\VLV WKH PLQLPDO FHOO UDGLXV DVSHFW UDWLR FHOO URXQGQHVV DQG FRPSDFWQHVV ZHUH DOO VWDWLVWLFDOO\GLᚎHUHQWDFURVVDOO*OHDVRQVFRUHFDVHV$129$S 6SKHULFLW\ VROLGLW\ VKDSH DQG FLUFXODULW\ ZHUH VWDWLVWLFDOO\ GLᚎHUHQW EHWZHHQ FDVHV ZLWK *OHDVRQVFRUHDQGWKRVHZLWKDVFRUHRIDQG$129$S +RZHYHU WKHVHSDUDPHWHUVZHUHQRWGLᚎHUHQWEHWZHHQFDVHVZLWKD*OHDVRQVFRUHRIDQG
Eur Urol Suppl 2010;9(2):67