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1103 poster A comparative dataset of six cancers in European Countries
Posters
S463
1103 poster
A comparative dataset of six cancers in European Countries
L. Maher, M. McGarry, A.L. McMahon, R. Sheehan, Y. Slowey, K.D. Stacey Trinity College Dublin, School of Radiation Therapy, Dublin, Ireland Introduction : Cancer Registries are vital in understanding the extent and impact of cancer on a country, and are fast becoming more common. We looked at six cancers listed in the EUCAN database: oesophageal cancer, colon/rectal cancer, bronchus/lung cancer, prostate cancer, breast cancer, and cancer of the cervix uteri. These cancers are diverse in their treatment, screening and aetiology. Materials and Methods : The data used in this paper was obtained from the EUCAN Database found at the following web address: http://www-dep.iarc.fr/eucan/eucan.htm. The data on this website represented cancer statistics for all European Union Countries for the year 1998. We extracted data on the incidence, and mortality of the above diseases and calculated the mortality:incidence ratio (M:I). Results: The
countries with
the highest
incidence
of
oesophageal cancer are Ireland and the United Kingdom, while Greece has the lowest incidence rate. Oesophageal cancer carries a high mortality (M:I above 0.84:1 in all countries). Ireland has the highest incidence of colon~rectal cancer in males but an overall M:I ratio of 0.46, lower than the EU average. Greece has the lowest incidence once again. This may be due in part to the Mediterranean diet. Overall, Denmark has the highest M:I ratio and incidence. Belgium and Ireland present with the highest incidence of
lung cancer in Europe. There are considerable differences betweeh the incidences in males and females. The M:I ratio is extremely high for lung cancer. Ireland is second only to Sweden in terms of the worst survival from lung cancer. Spain has the lowest M:I ratio for both sexes of lung cancer. Denmark has the highest incidence of breast cancer in the EU. Ireland has the highest M:I ratio in Europe - over 35% of women diagnosed with breast cancer in Ireland die from the disease. There is approximately a three-fold increase in the rate of cervical cancer from the country with the lowest incidence to the country with the highest incidence. Finland has the lowest incidence and M:I ratio, possibly attributable to an established national cervical cancer screening programme. Although Denmark has the highest incidence it features sixth highest in Europe for M:I ratio. The U.K has the highest M:I ratio in Europe. Finland has the highest incidence of prostate cancer while Greece has the lowest. The very high level in Finland is possibly due to screening.
Conclusion: Our study confirms that cancer is a major concern to the National Health Services within EU countries. It is likely that cancer registries will play a greater role in treatment, research and prevention. More information will be required on epidemiological factors to better shape cancer treatment. The effectiveness of screening programmes is one instance where this applies.
1104 poster The conception and development radiotherapy research facility
of
a
dedicated
J. Davies ~, J, Stratford, C. McCarthj, B. Porritt ~, C. Moore 2, J. S ~ , A. Amer2, C. McBain 3, A. Henry3, P. Price 3 ~Christie Hospital Manchester, Wade Centre for Radiotherapy Research, Manchester, United Kingdom 2Christie Hospiptal, Developing Technology Group Nrothwest Medical Physics, Manchester, United Kingdom 3Christie Hospital, Academic Department of Radiation Oncology, Manchester, United Kingdom The Christie Hospital Manchester was the first in the UK and one of four worldwide to install a Synergy System (ELEKTA Oncology Systems). This is sited within a dedicated Radiotherapy Research Facility. The Wade Centre became fully operational in 2002. The primary aims of this centre were to undertake technical radiotherapy research, implement new technologies, and provide staff with time, education and opportunity to develop new ideas. The facility comprises a Synergy Medical Linear Accelerator with Electronic Portal Imaging, and X Ray volumetric Imaging (Cone Beam CT) ELEKTA Oncology Systems. Planning systems used are Plato and Pinnacle. Our current programme includes, research and development of Image Guided Radiotherapy (IGRT) using X-ray Volumetric Imaging. This allows 3D visualisation of internal organs whilst in treatment position. Tumour tracking is also possible using kV fluoroscopy. IMRT trials are ongoing at various anatomical sites with the recent completion of a hypo-fractionation prostate IMRT trial. Projects involving novel ideas such as patient surface sensing during treatment are being developed, and some national and international trials are treated within the Wade. Radiographers employed within the facility have become an integral part in the research process from developing protocols and strategies, to the analysis of study data; they have expanded their role to be part of a fully multi-disciplinary team. There have been many challenges in the development of this facility and its unique technology. Experience has shown that new equipment and staff does not guarantee success. Issues of training, patient throughput and multidisciplinary teamwork have all been addressed, The practicalities and constraints encountered by the operation and performance of new equipment and translation into a clinical working environment has been challenging. The support from other disciplines and departments, educational and academic requirements, firm commitment to skill mix, a structured organised business plan and clear vision is imperative. These issues will be discussed. 1105 poster Effect of CT Data Acquisition on Dose Calculation by Radiation Treatment Planning System
S. Takahashi ~, K. Omoto 1, 7-. Nishimura ~, A. Matsumura ~, S. Okui 1, A. Komatsu ~, N. Uchida 2, M. Notanf , N. Yamamoto 2, H. Kitagakf ~Shimane University Hospital, Radiology, Izumo, Japan 2Shimane University School of Medicine Univercity, Radiology, Izumo, Japan Purpose: With recent radiotherapy system development, three-dimensional radiation treatment planning (3D-RTP) system based on CT imaging has become essential. The 3DRTP system requires CT data, such as geometrical position and the volume of each target organ, as well as CT numbers for dose calculation. However, CT data can be influenced by the type of equipment and scanning parameters. The purpose of this experimental study was to evaluate factors
S463
1103 poster
A comparative dataset of six cancers in European Countries
L. Maher, M. McGarry, A.L. McMahon, R. Sheehan, Y. Slowey, K.D. Stacey Trinity College Dublin, School of Radiation Therapy, Dublin, Ireland Introduction : Cancer Registries are vital in understanding the extent and impact of cancer on a country, and are fast becoming more common. We looked at six cancers listed in the EUCAN database: oesophageal cancer, colon/rectal cancer, bronchus/lung cancer, prostate cancer, breast cancer, and cancer of the cervix uteri. These cancers are diverse in their treatment, screening and aetiology. Materials and Methods : The data used in this paper was obtained from the EUCAN Database found at the following web address: http://www-dep.iarc.fr/eucan/eucan.htm. The data on this website represented cancer statistics for all European Union Countries for the year 1998. We extracted data on the incidence, and mortality of the above diseases and calculated the mortality:incidence ratio (M:I). Results: The
countries with
the highest
incidence
of
oesophageal cancer are Ireland and the United Kingdom, while Greece has the lowest incidence rate. Oesophageal cancer carries a high mortality (M:I above 0.84:1 in all countries). Ireland has the highest incidence of colon~rectal cancer in males but an overall M:I ratio of 0.46, lower than the EU average. Greece has the lowest incidence once again. This may be due in part to the Mediterranean diet. Overall, Denmark has the highest M:I ratio and incidence. Belgium and Ireland present with the highest incidence of
lung cancer in Europe. There are considerable differences betweeh the incidences in males and females. The M:I ratio is extremely high for lung cancer. Ireland is second only to Sweden in terms of the worst survival from lung cancer. Spain has the lowest M:I ratio for both sexes of lung cancer. Denmark has the highest incidence of breast cancer in the EU. Ireland has the highest M:I ratio in Europe - over 35% of women diagnosed with breast cancer in Ireland die from the disease. There is approximately a three-fold increase in the rate of cervical cancer from the country with the lowest incidence to the country with the highest incidence. Finland has the lowest incidence and M:I ratio, possibly attributable to an established national cervical cancer screening programme. Although Denmark has the highest incidence it features sixth highest in Europe for M:I ratio. The U.K has the highest M:I ratio in Europe. Finland has the highest incidence of prostate cancer while Greece has the lowest. The very high level in Finland is possibly due to screening.
Conclusion: Our study confirms that cancer is a major concern to the National Health Services within EU countries. It is likely that cancer registries will play a greater role in treatment, research and prevention. More information will be required on epidemiological factors to better shape cancer treatment. The effectiveness of screening programmes is one instance where this applies.
1104 poster The conception and development radiotherapy research facility
of
a
dedicated
J. Davies ~, J, Stratford, C. McCarthj, B. Porritt ~, C. Moore 2, J. S ~ , A. Amer2, C. McBain 3, A. Henry3, P. Price 3 ~Christie Hospital Manchester, Wade Centre for Radiotherapy Research, Manchester, United Kingdom 2Christie Hospiptal, Developing Technology Group Nrothwest Medical Physics, Manchester, United Kingdom 3Christie Hospital, Academic Department of Radiation Oncology, Manchester, United Kingdom The Christie Hospital Manchester was the first in the UK and one of four worldwide to install a Synergy System (ELEKTA Oncology Systems). This is sited within a dedicated Radiotherapy Research Facility. The Wade Centre became fully operational in 2002. The primary aims of this centre were to undertake technical radiotherapy research, implement new technologies, and provide staff with time, education and opportunity to develop new ideas. The facility comprises a Synergy Medical Linear Accelerator with Electronic Portal Imaging, and X Ray volumetric Imaging (Cone Beam CT) ELEKTA Oncology Systems. Planning systems used are Plato and Pinnacle. Our current programme includes, research and development of Image Guided Radiotherapy (IGRT) using X-ray Volumetric Imaging. This allows 3D visualisation of internal organs whilst in treatment position. Tumour tracking is also possible using kV fluoroscopy. IMRT trials are ongoing at various anatomical sites with the recent completion of a hypo-fractionation prostate IMRT trial. Projects involving novel ideas such as patient surface sensing during treatment are being developed, and some national and international trials are treated within the Wade. Radiographers employed within the facility have become an integral part in the research process from developing protocols and strategies, to the analysis of study data; they have expanded their role to be part of a fully multi-disciplinary team. There have been many challenges in the development of this facility and its unique technology. Experience has shown that new equipment and staff does not guarantee success. Issues of training, patient throughput and multidisciplinary teamwork have all been addressed, The practicalities and constraints encountered by the operation and performance of new equipment and translation into a clinical working environment has been challenging. The support from other disciplines and departments, educational and academic requirements, firm commitment to skill mix, a structured organised business plan and clear vision is imperative. These issues will be discussed. 1105 poster Effect of CT Data Acquisition on Dose Calculation by Radiation Treatment Planning System
S. Takahashi ~, K. Omoto 1, 7-. Nishimura ~, A. Matsumura ~, S. Okui 1, A. Komatsu ~, N. Uchida 2, M. Notanf , N. Yamamoto 2, H. Kitagakf ~Shimane University Hospital, Radiology, Izumo, Japan 2Shimane University School of Medicine Univercity, Radiology, Izumo, Japan Purpose: With recent radiotherapy system development, three-dimensional radiation treatment planning (3D-RTP) system based on CT imaging has become essential. The 3DRTP system requires CT data, such as geometrical position and the volume of each target organ, as well as CT numbers for dose calculation. However, CT data can be influenced by the type of equipment and scanning parameters. The purpose of this experimental study was to evaluate factors