- Email: [email protected]
#19 Anterior cingulate activation and error processing during interferon-α treatment: A pathway to cytokine-induced behavioral symptoms
e10
Abstracts / Brain, Behavior, and Immunity 19 (2005) e1–e42
icantly by day 2 after the initiation of FS, and then gradually decreased; there were no significant differences between HC and FS mice by week 3. Repeated locomotor activity testing indicated that FS mice exhibited hyperactivity in a variety of movements (including ambulatory, stereotypic, vertical movements, and jump) and spent significantly more time in the center area of the testing field. However, no differences were observed between HC and FS animals in anxiety/depression-related tests (open field test, lightdark exploration, and forced swimming test). Significant increases in brain and spleen tissue arginase levels were detected in FS mice at week 3, which may suggest an ongoing anti-inflammatory response initiated during chronic FS. Additionally, FS mice immunized with KLH at week 3 showed significant decreases in antibody responses 7 and 14 days later (total serum IgM, IgG, IgG1, and IgG2a). However, in vitro KLH stimulation of splenocytes from FS mice did not indicate reduced production of cytokines, including no changes in IFNc, IL-2, IL-4, and IL-10 levels, compared to HC. Altogether, chronic FS induced transient activation of the hypothalamic–pituitary–adrenal (HPA) axis and a distinct type of hyperactivity, which are associated with decreased antibody responses to KLH and increased brain arginase activity. The involvement of inflammatory responses in behavioral and immune changes is under investigation.
the dorsal part of the anterior cingulate cortex (ACC), which highly correlated with the number of task-related errors. No such correlation was found in controls. Consistent with the role of the ACC in conflict monitoring, ACC activation during IFN-a administration suggests that cytokines may increase processing conflict or reduce the threshold for conflict detection, thereby signaling the need to exert greater mental effort to maintain performance. Such alterations in ACC activity may in turn contribute to cytokine-induced behavioral changes. Acknowledgments Supported by the Centers for Disease Control and Prevention, the National Institute of Mental Health (MH067990 and MH069124), the National Institute of Biomedical Imaging and Bioengineering (EB002635) and the National Institute of Drug Abuse (DA00367). doi:10.1016/j.bbi.2005.10.025
#20 Relationships between sleep quality, endocrine status, and stress and mood in breast cancer patients Linda E. Carlson a,b,c, Tavis S. Campbell c, Paul Grossman d a
Acknowledgment Supported by PHS 1 R01 AI47288. doi:10.1016/j.bbi.2005.10.024
#19 Anterior cingulate activation and error processing during interferon-a treatment: A pathway to cytokine-induced behavioral symptoms Lucile Capuron Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA There has been increasing interest in the role of immunological processes, notably cytokines, in the development of behavioral alterations, especially in medically ill patients. Interferon (IFN)-a therapy is notorious for causing behavioral symptoms including depression, fatigue, and cognitive dysfunction and has been used to investigate the effects of cytokines on the brain. The present study assessed the effects of low dose IFN-a on brain activity using fMRI during a task of visuo-spatial attention in patients infected with hepatitis C virus (HCV). Despite endorsing symptoms of impaired concentration and fatigue, IFN-a-treated patients exhibited task performance and activation of parietal and occipital brain regions similar to HCV-infected controls. Interestingly, however, in contrast to controls, IFN-a-treated patients exhibited significant activation in
University of Calgary, Department of Oncology, Canada Tom Baker Cancer Centre, Alberta Cancer Board, Canada c University of Calgary, Department of Psychology, Canada d Freiburg Institute for Mindfulness Research, Germany b
Objectives. (1) To assess the extent of circadian dysregulation in neuroendocrine and sleep systems in women with breast cancer; (2) to measure the degree of association among measures in these biological systems; and (3) to measure associations between circadian dysregulation and psychological measures of stress and mood disturbance. Methods. Women with breast cancer who had completed cancer treatments provided urine samples for 24 h catecholamines, four salivary cortisol samples (30 min from waking, 12:00, 17:00, before bed), and completed questionnaires assessing quality of life (FACT-G), sleep (PSQI), stress (SOSI), mood (POMS), depression (CES-D), and anxiety (STAI). Results. Subjects were 33 women with breast cancer, an average of 51 years of age, 14 years education, 1.4 years since diagnosis, 88% Caucasian, 61% married, 27% stage I, 39% stage II, and 33% stage III cancer. Creatinine-corrected NE and E levels were in the normal range, as were CRT levels. Scores indicate mild mood disturbance and moderate stress levels, with anxiety similar to a working adult population. Half the sample was over the PSQI cutoff of 8, indicating significant sleep disturbance. Morning CRT was negatively associated with NE levels (p < .05), but otherwise measures of endocrine function were not related to one another or to self-reported measures of mood, sleep or stress. Sleep disturbance was positively associated with
Abstracts / Brain, Behavior, and Immunity 19 (2005) e1–e42
icantly by day 2 after the initiation of FS, and then gradually decreased; there were no significant differences between HC and FS mice by week 3. Repeated locomotor activity testing indicated that FS mice exhibited hyperactivity in a variety of movements (including ambulatory, stereotypic, vertical movements, and jump) and spent significantly more time in the center area of the testing field. However, no differences were observed between HC and FS animals in anxiety/depression-related tests (open field test, lightdark exploration, and forced swimming test). Significant increases in brain and spleen tissue arginase levels were detected in FS mice at week 3, which may suggest an ongoing anti-inflammatory response initiated during chronic FS. Additionally, FS mice immunized with KLH at week 3 showed significant decreases in antibody responses 7 and 14 days later (total serum IgM, IgG, IgG1, and IgG2a). However, in vitro KLH stimulation of splenocytes from FS mice did not indicate reduced production of cytokines, including no changes in IFNc, IL-2, IL-4, and IL-10 levels, compared to HC. Altogether, chronic FS induced transient activation of the hypothalamic–pituitary–adrenal (HPA) axis and a distinct type of hyperactivity, which are associated with decreased antibody responses to KLH and increased brain arginase activity. The involvement of inflammatory responses in behavioral and immune changes is under investigation.
the dorsal part of the anterior cingulate cortex (ACC), which highly correlated with the number of task-related errors. No such correlation was found in controls. Consistent with the role of the ACC in conflict monitoring, ACC activation during IFN-a administration suggests that cytokines may increase processing conflict or reduce the threshold for conflict detection, thereby signaling the need to exert greater mental effort to maintain performance. Such alterations in ACC activity may in turn contribute to cytokine-induced behavioral changes. Acknowledgments Supported by the Centers for Disease Control and Prevention, the National Institute of Mental Health (MH067990 and MH069124), the National Institute of Biomedical Imaging and Bioengineering (EB002635) and the National Institute of Drug Abuse (DA00367). doi:10.1016/j.bbi.2005.10.025
#20 Relationships between sleep quality, endocrine status, and stress and mood in breast cancer patients Linda E. Carlson a,b,c, Tavis S. Campbell c, Paul Grossman d a
Acknowledgment Supported by PHS 1 R01 AI47288. doi:10.1016/j.bbi.2005.10.024
#19 Anterior cingulate activation and error processing during interferon-a treatment: A pathway to cytokine-induced behavioral symptoms Lucile Capuron Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA There has been increasing interest in the role of immunological processes, notably cytokines, in the development of behavioral alterations, especially in medically ill patients. Interferon (IFN)-a therapy is notorious for causing behavioral symptoms including depression, fatigue, and cognitive dysfunction and has been used to investigate the effects of cytokines on the brain. The present study assessed the effects of low dose IFN-a on brain activity using fMRI during a task of visuo-spatial attention in patients infected with hepatitis C virus (HCV). Despite endorsing symptoms of impaired concentration and fatigue, IFN-a-treated patients exhibited task performance and activation of parietal and occipital brain regions similar to HCV-infected controls. Interestingly, however, in contrast to controls, IFN-a-treated patients exhibited significant activation in
University of Calgary, Department of Oncology, Canada Tom Baker Cancer Centre, Alberta Cancer Board, Canada c University of Calgary, Department of Psychology, Canada d Freiburg Institute for Mindfulness Research, Germany b
Objectives. (1) To assess the extent of circadian dysregulation in neuroendocrine and sleep systems in women with breast cancer; (2) to measure the degree of association among measures in these biological systems; and (3) to measure associations between circadian dysregulation and psychological measures of stress and mood disturbance. Methods. Women with breast cancer who had completed cancer treatments provided urine samples for 24 h catecholamines, four salivary cortisol samples (30 min from waking, 12:00, 17:00, before bed), and completed questionnaires assessing quality of life (FACT-G), sleep (PSQI), stress (SOSI), mood (POMS), depression (CES-D), and anxiety (STAI). Results. Subjects were 33 women with breast cancer, an average of 51 years of age, 14 years education, 1.4 years since diagnosis, 88% Caucasian, 61% married, 27% stage I, 39% stage II, and 33% stage III cancer. Creatinine-corrected NE and E levels were in the normal range, as were CRT levels. Scores indicate mild mood disturbance and moderate stress levels, with anxiety similar to a working adult population. Half the sample was over the PSQI cutoff of 8, indicating significant sleep disturbance. Morning CRT was negatively associated with NE levels (p < .05), but otherwise measures of endocrine function were not related to one another or to self-reported measures of mood, sleep or stress. Sleep disturbance was positively associated with