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20 P Correlations between model for end-stage liver disease and 13C aminopyrine breath test in patients with liver cirrhosis
ABLATION CARCINOMA
TN PRF”,O”SLY
,‘RtATFD
AliD
UNTREATED
KEPATOCFl
I LXAR
Hackground and am I” patients wth liver crrhoitr. proiemenergy malnutmi”” ii a frequenf findIng and a nsk factor ~n”ue”c~“g suwwal Auns were to assess both ““tntional status and dtetary mtake I” pabents with Child A or B cmhasis, and to esf,mate the etTect< of a regular oral dtet on thar mal”utnt,on and cbmcal outcome Pments and methods Twenty-six con~ecufwe pattents (b”F=l5111) w”h lbver curhorns. 1” m Chtld cI.ss A and 16 in class 8, were evaluated by anamnesis. c,,“,cal exam,“atio”. emrmt~o” ofdady caloric >“take and mea~ureme”, ofanthropometrical and hmchemxai Indexes A” oral regular dtet w”h an average 30-40 Kc&l& ofdertderable body weight was staned one week after the first exam,“at,o” The follow-q war performed after 3 and 6 months Results A? basehe, lbptd malnutritm”, assessed by traps sktnfold thickness v&es. was ievere I” 34 6% of paoentr, moderate ,” 7 7%. and mdd m 19 2%. and unproved at the end of the study (o-0 06, “rota” malnutnt~o”. assessed by creattnme-haah, Index KHI,. that
18 oc CORRELATIONS AMINOPYRTNE t
Scalice.
4 ROCCO. I. Cimm,
Dipadmento dl Medana Fed&co II, Napob
G Buddlon,
Cbnnca
G Nardone
e Spenmentale,
Canedra
dl Fastroenterologm,
U”wers”a
.,
. :. :
I:.
.
-*;;+ .‘c:: . ..a
A48 11_-_-__--11__-_-l_l.
E Ciannini, F. Bona. A Fasoli, P Romagnoli. Polegsto, A Fumagalh, R Testa. Catedra
l”troduct,o” The i3C.amlnopynne breath test (ABT) ts the only “0” m”~si”e. I” Yi”” method exploring her mlCr”l”ml*l “lass ABT meas”reS hepatocellular iimct~onal reserve and has bee” wdely used for the t”m”g ofonhotopx lbver transplant Untd now, no data are available on the rehablbty of ABT I” chrontc liver disease patients wthout chnc~t, laboratory, endascop~c and ultrasound markers of advanced dnsease Am To evaluate the reliability of ABT I” the d~scmmnattng chronx hepatitis (CH) and early crrhor~r (LC) Patients and methods The study population was consmuted of69 suhjeas (M/F 36133, mean age 52 years) referred to our department for characterization of poa-vsal liver dnease In each patient laborataly tests, endascopy, ultrasound, lwer bxopsy and ABT analyses were pelformed Alcoholic abuse was excluded m all cases Lwer disease was ixrtologdty scowi according to lshak crxteria ABT was performed admnntstrat~ng I X-aminopyrine 2 @kg m 200 ml ofwater *er an overnight fasting Breath samples were collected baseline and every 30 mi” for 2 h after oral load The samples were examlnated by an mtope mass spectrometer (Europe ABCA 2000) Results \yere expressed as %1X dose/h al the peak and %13C cumulatwe dose 120 ““n Results CH was detected I” 55 patents (80 %), and LC I” the rematntng 14 (20%) The two groups did “ot dnffer for laboratory tests nor for endoscoprc and ultrasound tindtngs ABT was xnpaired in 5 out of 55 (9%) of CH, and I” 9 out of 14 (64%) ofL.C (p
,.. ‘.~..
BETWEEN MODEL FOR END-STAGE BREATH TEST IN PATIENTS WITH
di Gastroentrrologm.
D!partlme”to
E Testa.
di Medwna
LIVER DISEASE LIVER CIRXHOSlS B Chiarbonello.
Intern”.
AND
F. M”lfattl,
13C S
&nova
Background. The Model for End-stage Liver Disease (MELD) has recently bee” (“trodwed as a promising tool Lo evaluate tic prognoses of crrhotlc pallems and overcome the rhartcomings oftbe Child-Pugh ‘s score (CPS). Lover foncttonal eval”afio” by means of ‘C Ammopyrine Breath Test (ABT) has prewously bee” ndentlfied as parameter predictive of sunwd m cirhotlc patients. Ams. To assess the relatlonshqx among the MELD, CPS, and ABT in a scrics of mrrhotlc m,ents. batients and Methods. We wdicd 73 cirrhooc patients (malelfemale=56ll7, age=60 +12 yews) Pony-four patients were CP class A, 2 I B, and 8 C. MELD was calculated according to the formula proposed by the Mayo Chnx, not considering aetiology of dtsease. ABT was performed m each patient (ABT, 2 mgiKg body wetght of ’ ‘C Armnopyrine per OS, substrates I ‘C labelled, supphed by Cortex, Milan, Italy) and / ‘CO2 concenfratio” 1” breath samples was detected every 30 minutes from t0 to tl20 by means of mass spectrometer. ABT Results are expressed as cumulative percentage of administered dose of ’ ‘C recovered over Ume (% I ‘C cum) and percentage of administered dose of 1 ‘C recovered per hour (9~ C D/hr). Correlations between varmbles were analysed by means of Pearson ‘s correlation coefficient or Spearman ‘s rank correlation test: differences among parameters were evaluated by Analysns of the “anance (ANOVA). Results MELD was s,gnlficantly ,“versely corn&ted to both ABT % ’ ‘C cum (, from 0.33Oto -0.219 and p ftom O.OMto&OOS) and% I 1C Di?lr (I from -d415to -0 238, p from 0.0003100.042) at each samphng ume. Moreover, MELD was significantly different among the various Child-Pugh ‘s classes (p
TN PRF”,O”SLY
,‘RtATFD
AliD
UNTREATED
KEPATOCFl
I LXAR
Hackground and am I” patients wth liver crrhoitr. proiemenergy malnutmi”” ii a frequenf findIng and a nsk factor ~n”ue”c~“g suwwal Auns were to assess both ““tntional status and dtetary mtake I” pabents with Child A or B cmhasis, and to esf,mate the etTect< of a regular oral dtet on thar mal”utnt,on and cbmcal outcome Pments and methods Twenty-six con~ecufwe pattents (b”F=l5111) w”h lbver curhorns. 1” m Chtld cI.ss A and 16 in class 8, were evaluated by anamnesis. c,,“,cal exam,“atio”. emrmt~o” ofdady caloric >“take and mea~ureme”, ofanthropometrical and hmchemxai Indexes A” oral regular dtet w”h an average 30-40 Kc&l& ofdertderable body weight was staned one week after the first exam,“at,o” The follow-q war performed after 3 and 6 months Results A? basehe, lbptd malnutritm”, assessed by traps sktnfold thickness v&es. was ievere I” 34 6% of paoentr, moderate ,” 7 7%. and mdd m 19 2%. and unproved at the end of the study (o-0 06, “rota” malnutnt~o”. assessed by creattnme-haah, Index KHI,. that
18 oc CORRELATIONS AMINOPYRTNE t
Scalice.
4 ROCCO. I. Cimm,
Dipadmento dl Medana Fed&co II, Napob
G Buddlon,
Cbnnca
G Nardone
e Spenmentale,
Canedra
dl Fastroenterologm,
U”wers”a
.,
. :. :
I:.
.
-*;;+ .‘c:: . ..a
A48 11_-_-__--11__-_-l_l.
E Ciannini, F. Bona. A Fasoli, P Romagnoli. Polegsto, A Fumagalh, R Testa. Catedra
l”troduct,o” The i3C.amlnopynne breath test (ABT) ts the only “0” m”~si”e. I” Yi”” method exploring her mlCr”l”ml*l “lass ABT meas”reS hepatocellular iimct~onal reserve and has bee” wdely used for the t”m”g ofonhotopx lbver transplant Untd now, no data are available on the rehablbty of ABT I” chrontc liver disease patients wthout chnc~t, laboratory, endascop~c and ultrasound markers of advanced dnsease Am To evaluate the reliability of ABT I” the d~scmmnattng chronx hepatitis (CH) and early crrhor~r (LC) Patients and methods The study population was consmuted of69 suhjeas (M/F 36133, mean age 52 years) referred to our department for characterization of poa-vsal liver dnease In each patient laborataly tests, endascopy, ultrasound, lwer bxopsy and ABT analyses were pelformed Alcoholic abuse was excluded m all cases Lwer disease was ixrtologdty scowi according to lshak crxteria ABT was performed admnntstrat~ng I X-aminopyrine 2 @kg m 200 ml ofwater *er an overnight fasting Breath samples were collected baseline and every 30 mi” for 2 h after oral load The samples were examlnated by an mtope mass spectrometer (Europe ABCA 2000) Results \yere expressed as %1X dose/h al the peak and %13C cumulatwe dose 120 ““n Results CH was detected I” 55 patents (80 %), and LC I” the rematntng 14 (20%) The two groups did “ot dnffer for laboratory tests nor for endoscoprc and ultrasound tindtngs ABT was xnpaired in 5 out of 55 (9%) of CH, and I” 9 out of 14 (64%) ofL.C (p
,.. ‘.~..
BETWEEN MODEL FOR END-STAGE BREATH TEST IN PATIENTS WITH
di Gastroentrrologm.
D!partlme”to
E Testa.
di Medwna
LIVER DISEASE LIVER CIRXHOSlS B Chiarbonello.
Intern”.
AND
F. M”lfattl,
13C S
&nova
Background. The Model for End-stage Liver Disease (MELD) has recently bee” (“trodwed as a promising tool Lo evaluate tic prognoses of crrhotlc pallems and overcome the rhartcomings oftbe Child-Pugh ‘s score (CPS). Lover foncttonal eval”afio” by means of ‘C Ammopyrine Breath Test (ABT) has prewously bee” ndentlfied as parameter predictive of sunwd m cirhotlc patients. Ams. To assess the relatlonshqx among the MELD, CPS, and ABT in a scrics of mrrhotlc m,ents. batients and Methods. We wdicd 73 cirrhooc patients (malelfemale=56ll7, age=60 +12 yews) Pony-four patients were CP class A, 2 I B, and 8 C. MELD was calculated according to the formula proposed by the Mayo Chnx, not considering aetiology of dtsease. ABT was performed m each patient (ABT, 2 mgiKg body wetght of ’ ‘C Armnopyrine per OS, substrates I ‘C labelled, supphed by Cortex, Milan, Italy) and / ‘CO2 concenfratio” 1” breath samples was detected every 30 minutes from t0 to tl20 by means of mass spectrometer. ABT Results are expressed as cumulative percentage of administered dose of ’ ‘C recovered over Ume (% I ‘C cum) and percentage of administered dose of 1 ‘C recovered per hour (9~ C D/hr). Correlations between varmbles were analysed by means of Pearson ‘s correlation coefficient or Spearman ‘s rank correlation test: differences among parameters were evaluated by Analysns of the “anance (ANOVA). Results MELD was s,gnlficantly ,“versely corn&ted to both ABT % ’ ‘C cum (, from 0.33Oto -0.219 and p ftom O.OMto&OOS) and% I 1C Di?lr (I from -d415to -0 238, p from 0.0003100.042) at each samphng ume. Moreover, MELD was significantly different among the various Child-Pugh ‘s classes (p