- Email: [email protected]
24 Nutrigenomics, a contribution to public health
Posters the stomach and rapid release in the small intestine special micro pellets with two coatings are used for the application of the Xylose Isomerase. In the resulting formulation the enzyme is stable at room temperature for more than two years, resistant to acids for at least 15 minutes and liberated within 15 minutes in the small intestine. Preliminary data of an observational study using this XI-formulation as food supplement verify in vitro data of fructose elimination: 66% of volunteers suffering from fructose malabsorption state “good effect”, 22% “little effect” and 11% found “no effect” of the enzyme in respect to intestinal irritations after consumption of fructose. Reference(s) [1] SH, Bhosale, MB, Rao, VV, Deshpande: Molecular and industrial aspects of glucose isomerase. Microbiol Rev 60: 280, 1996. [2] PR, Gibson, E, Newnham, JS, Barrett, SJ, Shepherd, JG, Muir: Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol Ther. 25: 349, 2007.
23 Attenuation of common cold symptoms by encapsulated juice powder concentrate S. Roll1 , M. Nocon1,2 , S.N. Willich1 . 1 Institut f¨ ur Sozialmedizin, Epidemiologie und Gesundheits¨ okonomie, atsmedizin Berlin, Germany; Charit´ e Universit¨ 2 Gemeinsamer Bundesausschuss, Berlin, Germany E-mail: [email protected] Introduction: Dietary supplements have been suggested as preventive strategies for common cold, but previous results were inconsistent [1]. This study aimed to assess the effect of a dietary supplement from fruits and vegetables on common cold symptoms in healthy healthcare professionals. Methods: This was a randomized double-blind placebocontrolled trial. Subjects were taking four capsules of dietary supplement (Juice Plus+® ) or matching placebo daily for eight months, including a two month run-in period. We report means and 95% confidence intervals (CI) for the number of days with at least moderate common cold symptoms (primary endpoint) and number of days with any common cold symptoms. Differences between groups are analyzed with ANOVA. Results: A total of 543 subjects were included, with 529 valid for primary analysis (intervention: 263, placebo: 266). The mean number of days with at least moderate common cold symptoms was 7.6 (95% CI 6.5 8.8) in the intervention and 9.5 (8.4 10.6) in the placebo group (P = 0.023). The mean number of days with any common cold symptoms was 29.4 (25.8 33.0) in the intervention and 30.7 (27.1 34.3) in the placebo group (P = 0.616). Conclusion: Intake of a dietary supplement from fruits and vegetables was associated with a reduction of moderate or severe common cold symptoms, but not with a reduction of total days with common cold symptoms. Research support: NSA (TN, USA) Reference(s) [1] Douglas R, Hemila H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007 Jul 18;(3): CD000980.
13 24 Nutrigenomics, a contribution to public health E. Schaeufele. Genolife® , Munich, Germany E-mail: [email protected] The inter-individual differences in gene sequences that result in differential responses to environmental factors, such as diet, lifestyle habits, and exposure to environmental toxins, have been one of the key discoveries of the Human Genome Project. The discipline of nutrigenomics studies how naturally occurring constituents of the diet alter the molecular expression of genetic information in individuals. Insight into the interaction between the environment and our genes and their expression is introducing a new era for nutritional counselling and medicine. Integrating this knowledge into personalised motivation programmes promotes sustained compliance with lifestyle recommendations. Substances in the diets of various cultures have been exerting profound influence on gene expression and the resulting proteome for thousands of years. Genetic differences between individuals are due to single nucleotide polymorphisms (SNPs). Motivating clients to adjust their lifestyles to their particular SNPs should prove to be an important contribution to public health. For instance, genetic studies have found that in as much as 20% of Caucasian females, dietary animal fats are more likely to prevent cardiovascular disease (CVD) than vegetable fats with polyunsaturated acids. Nutrigenetic testing therefore could reduce the increasing rate of myocardial infarction in women over 50 observed in this decade [in Germany, from 89 (2003) to 131 per 1,000 (2007)]. The three-year study presented here demonstrates how genetic testing can motivate clients to adopt health-conscious lifestyles and maintain compliance in the long term. 52 clients were observed concerning their lifestyle habits (diet and movement). Reference(s) [1] Subbiah MT. Nutrigenetics and nutraceuticals:the next wave riding on personalized medicine. Transl R., Journal of Laboratory and Clinical Medicine, Res. 2007 Feb; 149(2): 55 61. [2] Subbiah MT. Understanding the nutrigenomic definitions and concepts at the food-genome junction.OMICS. 2008 Dec; 12(4): 229 35. [3] Bazzano AT, et al. The Healthy Lifestyle Change Program: A pilot of a community-based health promotion intervention for adults. Am. Journ. of Prev. Med. 2009 Dec; 37, S201 8. [4] Schaeufele E. Motivation and Compliance, Lecture June 2008, Munich, GSAAM (Lifestyle Study on 31 Clients of Genolife, www.genolife.net).
25 Nutrigenetics and long term weight management: recent advances B. Weber. Laboratoires R´ eunis, Junglinster, Luxembourg E-mail: [email protected] Body weight is the result of genes, metabolism, behaviour, environment, culture, and socioeconomic status. More than 100 different gene variants have an impact on weight management and common obesity. These gene variants play a key role in energy expenditure,
23 Attenuation of common cold symptoms by encapsulated juice powder concentrate S. Roll1 , M. Nocon1,2 , S.N. Willich1 . 1 Institut f¨ ur Sozialmedizin, Epidemiologie und Gesundheits¨ okonomie, atsmedizin Berlin, Germany; Charit´ e Universit¨ 2 Gemeinsamer Bundesausschuss, Berlin, Germany E-mail: [email protected] Introduction: Dietary supplements have been suggested as preventive strategies for common cold, but previous results were inconsistent [1]. This study aimed to assess the effect of a dietary supplement from fruits and vegetables on common cold symptoms in healthy healthcare professionals. Methods: This was a randomized double-blind placebocontrolled trial. Subjects were taking four capsules of dietary supplement (Juice Plus+® ) or matching placebo daily for eight months, including a two month run-in period. We report means and 95% confidence intervals (CI) for the number of days with at least moderate common cold symptoms (primary endpoint) and number of days with any common cold symptoms. Differences between groups are analyzed with ANOVA. Results: A total of 543 subjects were included, with 529 valid for primary analysis (intervention: 263, placebo: 266). The mean number of days with at least moderate common cold symptoms was 7.6 (95% CI 6.5 8.8) in the intervention and 9.5 (8.4 10.6) in the placebo group (P = 0.023). The mean number of days with any common cold symptoms was 29.4 (25.8 33.0) in the intervention and 30.7 (27.1 34.3) in the placebo group (P = 0.616). Conclusion: Intake of a dietary supplement from fruits and vegetables was associated with a reduction of moderate or severe common cold symptoms, but not with a reduction of total days with common cold symptoms. Research support: NSA (TN, USA) Reference(s) [1] Douglas R, Hemila H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007 Jul 18;(3): CD000980.
13 24 Nutrigenomics, a contribution to public health E. Schaeufele. Genolife® , Munich, Germany E-mail: [email protected] The inter-individual differences in gene sequences that result in differential responses to environmental factors, such as diet, lifestyle habits, and exposure to environmental toxins, have been one of the key discoveries of the Human Genome Project. The discipline of nutrigenomics studies how naturally occurring constituents of the diet alter the molecular expression of genetic information in individuals. Insight into the interaction between the environment and our genes and their expression is introducing a new era for nutritional counselling and medicine. Integrating this knowledge into personalised motivation programmes promotes sustained compliance with lifestyle recommendations. Substances in the diets of various cultures have been exerting profound influence on gene expression and the resulting proteome for thousands of years. Genetic differences between individuals are due to single nucleotide polymorphisms (SNPs). Motivating clients to adjust their lifestyles to their particular SNPs should prove to be an important contribution to public health. For instance, genetic studies have found that in as much as 20% of Caucasian females, dietary animal fats are more likely to prevent cardiovascular disease (CVD) than vegetable fats with polyunsaturated acids. Nutrigenetic testing therefore could reduce the increasing rate of myocardial infarction in women over 50 observed in this decade [in Germany, from 89 (2003) to 131 per 1,000 (2007)]. The three-year study presented here demonstrates how genetic testing can motivate clients to adopt health-conscious lifestyles and maintain compliance in the long term. 52 clients were observed concerning their lifestyle habits (diet and movement). Reference(s) [1] Subbiah MT. Nutrigenetics and nutraceuticals:the next wave riding on personalized medicine. Transl R., Journal of Laboratory and Clinical Medicine, Res. 2007 Feb; 149(2): 55 61. [2] Subbiah MT. Understanding the nutrigenomic definitions and concepts at the food-genome junction.OMICS. 2008 Dec; 12(4): 229 35. [3] Bazzano AT, et al. The Healthy Lifestyle Change Program: A pilot of a community-based health promotion intervention for adults. Am. Journ. of Prev. Med. 2009 Dec; 37, S201 8. [4] Schaeufele E. Motivation and Compliance, Lecture June 2008, Munich, GSAAM (Lifestyle Study on 31 Clients of Genolife, www.genolife.net).
25 Nutrigenetics and long term weight management: recent advances B. Weber. Laboratoires R´ eunis, Junglinster, Luxembourg E-mail: [email protected] Body weight is the result of genes, metabolism, behaviour, environment, culture, and socioeconomic status. More than 100 different gene variants have an impact on weight management and common obesity. These gene variants play a key role in energy expenditure,