REGULA TED GENE EXPRESSION EGULATED 431. Keratinocyte Progenitor Cells T ransduced with a Transduced Selectable Marker Gene Can Be Enriched by T opical Topical Selection Wolfgang Pfutzner,1 Christine Tock,2 Atsushi Terunuma,2 Ellie Snead,2 Ted Kolodka,2 Jonathan Vogel.2 1 Department of Dermatology, Ludwig-Maximilians-Universität, Munich, Germany; 2Dermatology Branch, NCI, National Institutes of Health, Bethesda, United States. 3
! "
3 -A/ 3
-#$@/ ! A
#$@ C#$@8%' - &8H /
1
' & "
#$@
3 - / #$@ - 1 -!@// 0
#$@" 3 A -#$@JA 8=J%"&H ;J%"6H 5 8&
/
#$@JA -&9J%",BH 66J%"8&H / 0
-8,
;H#$@JA / #$@JA
-=;H#$@JA/ 8,
?
#$@" #$@JA
1 " !@
#$@
-886J%"968 9=6J%"98B M999:/ #$@JA
3
432. Strategies for the Regulation of Multiple Genes with Zinc Finger T ranscription Factors Transcription Karin Effertz, Pilar Blancafort, Laurent Magnenat, Carlos Barbas III. *
3 3
3 ?
G $
G $*' 0
-8/
G
-,=/ ?
C ) 3
G 4 1
0
8/( $<Y2 ? ) 26=6"=5-,999/ ,/2
@@( $<$ 2Y2 ?! *' (4('5&86B,:"86B==-855:/ =/2
@@$ 2Y2 ?! *' (4(' 5;865&"8&99-,999/
Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy
433. An Auto-Regulated, Doxycycline-Inducible FIVBased Lentiviral V ector Vector Dyana T. Saenz,1 Nils Loewen,1 Eric M. Poeschla.1 1 Molecular Medicine, Mayo Clinic, Rochester, MN, United States. " 3
3 1
3
"
- "/ -?./"
" 3 "
- '/
3 3
"
'
3 " ? &X =X "
- @>/ -@>(/ ' ' " 3
@>(
#.
?.
"
G
3 ?! '
""
3
?!
3 "
=5
@>( ' 3
( @>(" ' B
3
434. Regulation by Oxygen T ension and Tension Pharmacological Switch of T ransgene Expression for Transgene Gene Therapy E. Payen,1 Michael Bettan,2 A. Henri,1 E. Tomkiewitcz,1 A. Houque,1 I. Kuzniak,1 J. Zuber,1 Yves Beuzard,1 Daniel Scherman.2 1 Hopital Saint Louis, Paris, France; 2CNRS ENSCP Gencell, Vitry, France.
E
3 E 0
"
7 / 3 -C@>/
- '/ I / 3
-)$$/ ' 3 I / - " /
3
- /
3 3 3 3
3 3 E
3 3
"
435. Designed Zinc Finger Proteins Activate the GMCSF Gene and Function in Cells Infected by Adenovirus Andreas Reik,1 Bing Liu,1 Yi Gao,2 Sylvie Laquerre,2 Casey C. Case.1 1 Sangamo BioSciences, Richmond, Ca., United States; 2Onyx Pharmaceuticals, Richmond, Ca., United States. ( 2(
G -N?!/ 0 N?! 3
" " -#"(?/ " 2
N?!
#"(?
N?!
S141