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4460561 Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
PATENT ABSTRACTS
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446O561
4460576
TUMOR LOCALIZATION AND THERAPY WITH LABELED ANTIBODIES SPECIFIC TO INTRACELLULAR TUMORASSOCIATED MARKERS
PEPTIDE AND HORMONE AGENT CONTAINING THE SAME AS EFFECTIVE INGREDIENT Hiroshi Kawauchi, Iwate. Japan assigned to Kaken Pharmaceutical Co Ltd: Suntory Limit
M David Goldenberg Methods are provided for using radiolabeled antibodies specific to intracellular tumorassociated markers for detection, localization and therapy of tumors. Injectable compositions for use in the methods of the invention are also provided.
4460574 PROPHYLAXIS OR TREATMENT OF INTERFERON-SENSITIVE DISEASES Alexander A Yabrov Prophylaxis or treatment of interferon-sensitive diseases in a human is effected by the rectal or urogenital administration to a human of a liquid pharmaceutical composition of native human interferon (Types I and 11). said liquid pharmaceutical composition not being clinically appropriate for intravenous or intramuscular injection,
4460575 VACCINAL COMPLEX CONTAINING A SPECIFIC ANTIGEN AND VACCINE CONTAINING IT Lucien D d'Hinterland, Gacu/e/rard Normier. Anne-Marie Pinel, Jacques Durand, Castres, France assigned to Pierre Fabre S A The present invention relates to a vaccinal complex containing a specific antigen. This is a vaccinal complex characterized in that it is composed of bacterial ribosomal RNA or fragments of bacterial ribosomal RNA on which are coupled from 1 to 5°.gby weight of a specific antigen of bacterial serotype. This complex may be used as a vaccine.
A peptide having the structural formula (1): See Patent for Chemical Structure (I) wherein GIx is Glu or Gin, and the following physical properties: (1) Ultraviolet Absorption Spectrum: Max 280 rim.. (2) Ehrlich reaction, Sakaguchi reaction and Pauly's reaction: positive, (3) Basic, (4) Soluble in water, methanol and acetic acid. slightly soluble in ethyl acetate, butyl acetate. ethyl ether, hexane, petroleum ether, benzene and chloroform, and (5) white powder has a specifically GH-releasing effect and no speciesspecificity. The peptide is useful not only for human dwarfism and wound repair but also for stimulating a growth of domestic animal.
4460577 PHARMACEUTICAL COMPOSITIONS CONSISTING OR CONSISTING ESSENTIALLY OF LIPOSOMES, AND PROCESSES FOR MAKING SAME Luigi Moro, Guido Neri, Alessandro Rigamonti, Cairate, Italy assigned to Farmitalia Carlo Erba S p A A method is disclosed for purifying nonhomogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ionexchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic, or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium. primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde. styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensationresins. Treatment may also be carried out with polymers, copolymers, or mixtures thereof, not having any specific chemical function and which
40~
446O561
4460576
TUMOR LOCALIZATION AND THERAPY WITH LABELED ANTIBODIES SPECIFIC TO INTRACELLULAR TUMORASSOCIATED MARKERS
PEPTIDE AND HORMONE AGENT CONTAINING THE SAME AS EFFECTIVE INGREDIENT Hiroshi Kawauchi, Iwate. Japan assigned to Kaken Pharmaceutical Co Ltd: Suntory Limit
M David Goldenberg Methods are provided for using radiolabeled antibodies specific to intracellular tumorassociated markers for detection, localization and therapy of tumors. Injectable compositions for use in the methods of the invention are also provided.
4460574 PROPHYLAXIS OR TREATMENT OF INTERFERON-SENSITIVE DISEASES Alexander A Yabrov Prophylaxis or treatment of interferon-sensitive diseases in a human is effected by the rectal or urogenital administration to a human of a liquid pharmaceutical composition of native human interferon (Types I and 11). said liquid pharmaceutical composition not being clinically appropriate for intravenous or intramuscular injection,
4460575 VACCINAL COMPLEX CONTAINING A SPECIFIC ANTIGEN AND VACCINE CONTAINING IT Lucien D d'Hinterland, Gacu/e/rard Normier. Anne-Marie Pinel, Jacques Durand, Castres, France assigned to Pierre Fabre S A The present invention relates to a vaccinal complex containing a specific antigen. This is a vaccinal complex characterized in that it is composed of bacterial ribosomal RNA or fragments of bacterial ribosomal RNA on which are coupled from 1 to 5°.gby weight of a specific antigen of bacterial serotype. This complex may be used as a vaccine.
A peptide having the structural formula (1): See Patent for Chemical Structure (I) wherein GIx is Glu or Gin, and the following physical properties: (1) Ultraviolet Absorption Spectrum: Max 280 rim.. (2) Ehrlich reaction, Sakaguchi reaction and Pauly's reaction: positive, (3) Basic, (4) Soluble in water, methanol and acetic acid. slightly soluble in ethyl acetate, butyl acetate. ethyl ether, hexane, petroleum ether, benzene and chloroform, and (5) white powder has a specifically GH-releasing effect and no speciesspecificity. The peptide is useful not only for human dwarfism and wound repair but also for stimulating a growth of domestic animal.
4460577 PHARMACEUTICAL COMPOSITIONS CONSISTING OR CONSISTING ESSENTIALLY OF LIPOSOMES, AND PROCESSES FOR MAKING SAME Luigi Moro, Guido Neri, Alessandro Rigamonti, Cairate, Italy assigned to Farmitalia Carlo Erba S p A A method is disclosed for purifying nonhomogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ionexchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic, or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium. primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde. styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensationresins. Treatment may also be carried out with polymers, copolymers, or mixtures thereof, not having any specific chemical function and which