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4490385 Treatment of auto-immune and inflammatory diseases
121
PATENT ABSTRACTS
taking blood provides improved disease fighting characteristics in the derived product. Steps are provided for purification of the products such as removal of residual inducers or the treatment for presence of suspected hepatitis virus, etc.
is therefore effective for prevention or treatment of infectious diseases by such microorganisms.
4490363 4490358
METORPHAMIDE-A NOVEL MORPHINE-LIKE PEPTIDE
SCREENING VACCINES AND IMMUNIZATION PROCESS Mark I Greene, Bernard N Fields assigned to President and Fellows of Harvard College Mammals are vaccinated against infectious organisms and polypeptides are screened for utility as vaccines by a complementing set of monoclonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds specifically to a receptor on a host cell of the mammal, and the second of which binds specifically to the first. Vaccination is done with the second antibody alone, and screening is done by determining whether the polypeptide binds to the first antibody.
Jack D Barchas, Eckard Weber, Christopher Evans assigned to Board of Trustees of The Leland Stanford Junior University Stanford Univ A morphine-like amidated opioid octapeptide metorphamide having the structure Try-GlyGly-Phe-Met-Arg-Arg-Val-NH2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high mu-binding activity.
4490385 4490361
TREATMENT OF AUTO-IMMUNE AND INFLAMMATORY DISEASES
VIRUS INACTIVATING HEAT TREATMENT OF PLASMA FRACTIONS Charles Heldebrant assigned Therapeutic Corporation
to
Alpha
A process is provided for heat treating a protein powder that includes mixing the powder into an organic liquid to form a suspension and heating the suspension for a selected time at a selected temperature. Such heat treatment inactiviates any virus associated with the protein while not substantially impairing the biological activity of the protein.
4490362 IMMUNOPOTENTIATOR COMPRISING THE B CHAIN OF R I C I N AS AN ACTIVE INGREDIENT Hiroshi Shionoya, Hitoshi Takeuchi, Gunki Funatsu, Saitama, Japan assigned to Eisai Co Ltd An immunopotentiator comprising the B chain of ricin as an active ingredient. The immunopotentiator serves to increase immune response to fungi, viruses and other microorganisms and
Julia Lieb A method for the treatment of inflammatory disorders and disorders of immunity, which disorders are characterized by excessive prostaglandin E2 biosynthesis, which method comprises administering an effective amount of a monoamine oxidase inhibitor.
4491578 METHOD OF STIMULATING SATIETY IN MAMMALS Steven Peikin This disclosure relates to a method of eliciting satiety (psycho phenomenetic sense of being filled) in mammals through the administration of an effective amount of a trypsin inhibitor and is based on the postulate that the enzyme trypsin, normally secreted by the pancreas, constitutes a negative feedback signal for cholecystokinin secretion which in turn comprises a putative satiety signal; thus, the effect of the trypsin inhibitor is to increase the concentration of cholecystokinin secretion advancing the sensation of satiety resulting in a consequent decrease in food intake and, over time, body weight.
PATENT ABSTRACTS
taking blood provides improved disease fighting characteristics in the derived product. Steps are provided for purification of the products such as removal of residual inducers or the treatment for presence of suspected hepatitis virus, etc.
is therefore effective for prevention or treatment of infectious diseases by such microorganisms.
4490363 4490358
METORPHAMIDE-A NOVEL MORPHINE-LIKE PEPTIDE
SCREENING VACCINES AND IMMUNIZATION PROCESS Mark I Greene, Bernard N Fields assigned to President and Fellows of Harvard College Mammals are vaccinated against infectious organisms and polypeptides are screened for utility as vaccines by a complementing set of monoclonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds specifically to a receptor on a host cell of the mammal, and the second of which binds specifically to the first. Vaccination is done with the second antibody alone, and screening is done by determining whether the polypeptide binds to the first antibody.
Jack D Barchas, Eckard Weber, Christopher Evans assigned to Board of Trustees of The Leland Stanford Junior University Stanford Univ A morphine-like amidated opioid octapeptide metorphamide having the structure Try-GlyGly-Phe-Met-Arg-Arg-Val-NH2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high mu-binding activity.
4490385 4490361
TREATMENT OF AUTO-IMMUNE AND INFLAMMATORY DISEASES
VIRUS INACTIVATING HEAT TREATMENT OF PLASMA FRACTIONS Charles Heldebrant assigned Therapeutic Corporation
to
Alpha
A process is provided for heat treating a protein powder that includes mixing the powder into an organic liquid to form a suspension and heating the suspension for a selected time at a selected temperature. Such heat treatment inactiviates any virus associated with the protein while not substantially impairing the biological activity of the protein.
4490362 IMMUNOPOTENTIATOR COMPRISING THE B CHAIN OF R I C I N AS AN ACTIVE INGREDIENT Hiroshi Shionoya, Hitoshi Takeuchi, Gunki Funatsu, Saitama, Japan assigned to Eisai Co Ltd An immunopotentiator comprising the B chain of ricin as an active ingredient. The immunopotentiator serves to increase immune response to fungi, viruses and other microorganisms and
Julia Lieb A method for the treatment of inflammatory disorders and disorders of immunity, which disorders are characterized by excessive prostaglandin E2 biosynthesis, which method comprises administering an effective amount of a monoamine oxidase inhibitor.
4491578 METHOD OF STIMULATING SATIETY IN MAMMALS Steven Peikin This disclosure relates to a method of eliciting satiety (psycho phenomenetic sense of being filled) in mammals through the administration of an effective amount of a trypsin inhibitor and is based on the postulate that the enzyme trypsin, normally secreted by the pancreas, constitutes a negative feedback signal for cholecystokinin secretion which in turn comprises a putative satiety signal; thus, the effect of the trypsin inhibitor is to increase the concentration of cholecystokinin secretion advancing the sensation of satiety resulting in a consequent decrease in food intake and, over time, body weight.