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4P-1193 Effect of garlic on lipid profile and psychopathological parameters in people with mild-to-moderate hypercholesterolemia
Thursday October 2, 2003: Poster Session Alternative medicine 4P-1191
4P-1193
Patients and Method: 44 diabetic hemodialysed patients (18F and 26M; 17 type1 and 27 type 2; mean age 55y) were followed for a mean period of 13 months from the initiation of dialysis therapy. This cohort was divided into two groups, considering the discriminating value of CRP being 10mg/dl. The investigation protocol includes monthly determinations of Hb (Ht), serum creatinine, BUN and plasma albumin and three-month determinations of the other parameters. The p values ≤0.01 were considered statistically significant. Results: The factors associated with elevated CRP in our group were: the low serum creatinin during follow-up period (5.9 vs 7.5mg/dl, p=0.005); lower mean Ht (26.5 vs 30.3, p=0.0031); lower plasma albumin (3.53 vs 3.83g/dl, p=0.0089); lower HDL-cholesterol (31.6 vs 37.4mg/dl, p=0.003). The patients with high levels of CRP are more frequently insulin dependent, although the difference is not significant for the predicted power. Discussion: The associations found in our group between elevated plasma CRP and lower creatinine, albumin and hematocrite plasma levels are strengthening the relationship between chronic inflammation and denutrition in end stage chronic failure patients on hemodialysis. In our opinion, the presented data are supporting the hypothesis of intrinsic links between inflamation, malnutrition and atherosclerosis in these patients. 4P-1192
ALTERNATIVE MEDICINE
The relevance of elevated levels of C-reactive protein for the evolution and prognostic of diabetic patients on hemodialysis
S. Mateiciuc, C. Stanciu. Institute of Diabetes Nutrition and Metabolic Diseases, Bucharest, Romania
Impaired creatinine clearance is a risk factor for cardiovascular outcomes in patients with coronary heart disease and pravastatin reduces events similarly in patients with high and low creatinine clearance levels: results from the LIPID study
M. West 1 , C. Hargreaves 2 , A. Kirby 2 , J. Simes 2 , A. Tonkin 3 , D. Colquhoun 4 . 1 University of Queensland, Prince Charles Hospital, Brisbane; 2 NHMRC Clinical Trials Centre, University of Sydney, Sydney; 3 National Heart Foundation, Melbourne; 4 Wesley Hospital, Brisbane, Australia A post-hoc analysis of data from the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study was undertaken to determine the effects of the cholesterol-lowering drug, pravastatin, on cardiovascular outcomes in patients with chronic renal dysfunction. The LIPID study, a randomized, double-blind, placebo-controlled study of the clinical outcomes of treatment with pravastatin followed up 9014 patients with coronary heart disease and total cholesterol of 4.0–7.0 mmol/L for a mean period of 6 years. The effects of pravastatin on major cardiovascular outcomes were determined according to the level of creatinine clearance at randomization into the study (lower, <75 mL/min (n=4449) or higher, >75 mL/min (n=4565)) by using a Cox proportional hazards model. The event rates in each treatment group are shown in the Table. Outcome and Creatinine Group CHD death lower higher Coronary event lower higher Non-haemorrhagic stroke lower higher
n
Placebo Pravastatin Hazard (%) (%) Ratio
P
P for Interaction
399 261
4.9 3.4
4.1 2.3
0.83 0.66
0.067 <0.001
0.15
720 552
9.1 6.8
7.1 5.3
0.76 0.76
<0.001 0.001
1.00
223 127
2.7 1.6
2.3 1.2
0.70 0.70
0.130 0.050
0.50
Effect of garlic on lipid profile and psychopathological parameters in people with mild-to-moderate hypercholesterolemia
Y. Beigel 1 , T. Hershcovici 2 , R. Lipa 3 , R. Anbar 3 , M. Redler 3 , A. Peleg 4 . Center; 2 Hadassha Medical Center; 3 Rabin Medical University, Israel
1 Wolfson Medical Center; 4 Bar-Ilan
Objectve: To evaluate the effect of garlic on lipid parameters and on depression,impulsivity,hostility and temperament in patients with primary type 2 hyperlipidemia. Methods: In a 16-week prospective double-blind palcebo-controlled study, 33 patients with primary type 2 hyperlipidemia were assigned to receive either garlic or placebo.Thirteen patients received garlic in the form of alliin 22.4 mg/day and 20 received placebo.The change in lipid profile and various psychopathological parameters were determined at the beginning and end of the trial. Results: No significant changes were observed in the level of total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides or in depression,impulsivity,hostility and temperament. Conclusions: Short-term garlic therapy in adults with mild-to-moderate hypercholesterolemia does not affect eiher lipid levels or various psychopathological parameters. 4P-1194
Use of Chinese herbal medicine in hypertensive and dyslipidemic patients: A questionnaire survey
Q. Chen 1 , H. Zhao 1 , G.N. Thomas 2 , A.H.L. Critchley 1 , B. Tomlinson 1 . University of Hong Kong, Dept. of Medicine & Therapeutics, Prince of Wales Hospital; 2 University of Hong Kong, Hong Kong SAR
1 Chinese
Objectives: Atherosclerosis is the major cause of mortality and morbidity among hypertensive and dyslipidemic patients. Chinese herbal medicine is widely used in the management of hypertension and dyslipidemia in Chinese populations, but the extent of its use has not been documented clearly. We conducted a questionnaire survey to determine the proportion of patients who use Chinese herbal medicine and to identify the commonly used medicinal herbs. Information was also recorded about any suspected adverse effects. Methods: Patients with hypertension dyslipidemia were interviewed in clinics and asked to complete a two-page questionnaire on their use of Chinese herbal medicine. Results: Two hundred Chinese patients responded to the survey. About 80% of the patients took at least one herb for promoting health. Half of the patients had seen herbalists during the last one year, and herbal medicines were prescribed. Among those patients, at least 18% used the Chinese medicines to treat their hypertension and hyperlipidaemia. The other indications for herbal medicine prescriptions included common cold, cough, headache and insomnia. The commonly used herbal medicines were Huai Shan, Longan Pulp, Ginger, Wolfberry Fruit, Chrysanthemum, American Ginseng, Coix seed and Fragrant Solomonseal Rhizome. Over 76% of the patients claimed that their conditions were improved after taking the herbal medicines. Only 15% of the patients who took herbal medicines knew the ingredients of their prescriptions. Suspected adverse reactions including headache, stomach discomfort, comedo and nose bleeding were reported in a total of 2.8% of the patients. Conclusions: Chinese herbal medicine is widely used for health promotion, minor illnesses and cardiovascular disorders such as hypertension and dyslipidemia in Hong Kong Chinese. The herbal medicine is perceived by patients as a safe medication with possible minor adverse effects. 4P-1195
Prescription frequency of herbal medicines in Chinese patients with type 2 diabetes mellitus
H. Zhao 1 , Q. Chen 1 , A.-Z. Hao 2 , X.-M. Zou 2 , P. Tong 1 , J. Chan 1 , B. Tomlinson 1 . 1 Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR; 2 Chinese PLA General Hospital, China Type 2 diabetes is a major risk factor for atherosclerosis. Chinese herbal medicine has been used in correcting the multiple metabolic disorders and preventing chronic vascular complications of type 2 diabetes for thousands of years. We conducted a retrospective analysis of the prescriptions of the herbal medicines in out-patient clinics for Chinese patients with type 2 diabetes. Prescription records over the period of 1 December 1997 to 31 March 2002 at all out-patient clinics of a major medical center in Beijing were reviewed.
XIIIth International Symposium on Atherosclerosis, September 28–October 2, 2003, Kyoto, Japan
THURSDAY
Impaired creatinine clearance was associated with an increase in all cardiovascular events, except unstable angina pectoris, both before and after adjustment for other baseline risk factors (P<0.014 for all outcomes after adjustment for other risk factors). Impaired creatinine clearance was associated with a 3.3% increase in major CHD, a 4.1% increase in coronary events and a 2.2% increase in nonhaemorrhagic stroke (P<0.001 for all these events). There was no evidence of a difference in the effect of treatment with pravastatin on major cardiovascular outcomes between patients with a low creatinine clearance and patients with high creatinine clearance at baseline.
337
4P-1193
Patients and Method: 44 diabetic hemodialysed patients (18F and 26M; 17 type1 and 27 type 2; mean age 55y) were followed for a mean period of 13 months from the initiation of dialysis therapy. This cohort was divided into two groups, considering the discriminating value of CRP being 10mg/dl. The investigation protocol includes monthly determinations of Hb (Ht), serum creatinine, BUN and plasma albumin and three-month determinations of the other parameters. The p values ≤0.01 were considered statistically significant. Results: The factors associated with elevated CRP in our group were: the low serum creatinin during follow-up period (5.9 vs 7.5mg/dl, p=0.005); lower mean Ht (26.5 vs 30.3, p=0.0031); lower plasma albumin (3.53 vs 3.83g/dl, p=0.0089); lower HDL-cholesterol (31.6 vs 37.4mg/dl, p=0.003). The patients with high levels of CRP are more frequently insulin dependent, although the difference is not significant for the predicted power. Discussion: The associations found in our group between elevated plasma CRP and lower creatinine, albumin and hematocrite plasma levels are strengthening the relationship between chronic inflammation and denutrition in end stage chronic failure patients on hemodialysis. In our opinion, the presented data are supporting the hypothesis of intrinsic links between inflamation, malnutrition and atherosclerosis in these patients. 4P-1192
ALTERNATIVE MEDICINE
The relevance of elevated levels of C-reactive protein for the evolution and prognostic of diabetic patients on hemodialysis
S. Mateiciuc, C. Stanciu. Institute of Diabetes Nutrition and Metabolic Diseases, Bucharest, Romania
Impaired creatinine clearance is a risk factor for cardiovascular outcomes in patients with coronary heart disease and pravastatin reduces events similarly in patients with high and low creatinine clearance levels: results from the LIPID study
M. West 1 , C. Hargreaves 2 , A. Kirby 2 , J. Simes 2 , A. Tonkin 3 , D. Colquhoun 4 . 1 University of Queensland, Prince Charles Hospital, Brisbane; 2 NHMRC Clinical Trials Centre, University of Sydney, Sydney; 3 National Heart Foundation, Melbourne; 4 Wesley Hospital, Brisbane, Australia A post-hoc analysis of data from the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study was undertaken to determine the effects of the cholesterol-lowering drug, pravastatin, on cardiovascular outcomes in patients with chronic renal dysfunction. The LIPID study, a randomized, double-blind, placebo-controlled study of the clinical outcomes of treatment with pravastatin followed up 9014 patients with coronary heart disease and total cholesterol of 4.0–7.0 mmol/L for a mean period of 6 years. The effects of pravastatin on major cardiovascular outcomes were determined according to the level of creatinine clearance at randomization into the study (lower, <75 mL/min (n=4449) or higher, >75 mL/min (n=4565)) by using a Cox proportional hazards model. The event rates in each treatment group are shown in the Table. Outcome and Creatinine Group CHD death lower higher Coronary event lower higher Non-haemorrhagic stroke lower higher
n
Placebo Pravastatin Hazard (%) (%) Ratio
P
P for Interaction
399 261
4.9 3.4
4.1 2.3
0.83 0.66
0.067 <0.001
0.15
720 552
9.1 6.8
7.1 5.3
0.76 0.76
<0.001 0.001
1.00
223 127
2.7 1.6
2.3 1.2
0.70 0.70
0.130 0.050
0.50
Effect of garlic on lipid profile and psychopathological parameters in people with mild-to-moderate hypercholesterolemia
Y. Beigel 1 , T. Hershcovici 2 , R. Lipa 3 , R. Anbar 3 , M. Redler 3 , A. Peleg 4 . Center; 2 Hadassha Medical Center; 3 Rabin Medical University, Israel
1 Wolfson Medical Center; 4 Bar-Ilan
Objectve: To evaluate the effect of garlic on lipid parameters and on depression,impulsivity,hostility and temperament in patients with primary type 2 hyperlipidemia. Methods: In a 16-week prospective double-blind palcebo-controlled study, 33 patients with primary type 2 hyperlipidemia were assigned to receive either garlic or placebo.Thirteen patients received garlic in the form of alliin 22.4 mg/day and 20 received placebo.The change in lipid profile and various psychopathological parameters were determined at the beginning and end of the trial. Results: No significant changes were observed in the level of total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides or in depression,impulsivity,hostility and temperament. Conclusions: Short-term garlic therapy in adults with mild-to-moderate hypercholesterolemia does not affect eiher lipid levels or various psychopathological parameters. 4P-1194
Use of Chinese herbal medicine in hypertensive and dyslipidemic patients: A questionnaire survey
Q. Chen 1 , H. Zhao 1 , G.N. Thomas 2 , A.H.L. Critchley 1 , B. Tomlinson 1 . University of Hong Kong, Dept. of Medicine & Therapeutics, Prince of Wales Hospital; 2 University of Hong Kong, Hong Kong SAR
1 Chinese
Objectives: Atherosclerosis is the major cause of mortality and morbidity among hypertensive and dyslipidemic patients. Chinese herbal medicine is widely used in the management of hypertension and dyslipidemia in Chinese populations, but the extent of its use has not been documented clearly. We conducted a questionnaire survey to determine the proportion of patients who use Chinese herbal medicine and to identify the commonly used medicinal herbs. Information was also recorded about any suspected adverse effects. Methods: Patients with hypertension dyslipidemia were interviewed in clinics and asked to complete a two-page questionnaire on their use of Chinese herbal medicine. Results: Two hundred Chinese patients responded to the survey. About 80% of the patients took at least one herb for promoting health. Half of the patients had seen herbalists during the last one year, and herbal medicines were prescribed. Among those patients, at least 18% used the Chinese medicines to treat their hypertension and hyperlipidaemia. The other indications for herbal medicine prescriptions included common cold, cough, headache and insomnia. The commonly used herbal medicines were Huai Shan, Longan Pulp, Ginger, Wolfberry Fruit, Chrysanthemum, American Ginseng, Coix seed and Fragrant Solomonseal Rhizome. Over 76% of the patients claimed that their conditions were improved after taking the herbal medicines. Only 15% of the patients who took herbal medicines knew the ingredients of their prescriptions. Suspected adverse reactions including headache, stomach discomfort, comedo and nose bleeding were reported in a total of 2.8% of the patients. Conclusions: Chinese herbal medicine is widely used for health promotion, minor illnesses and cardiovascular disorders such as hypertension and dyslipidemia in Hong Kong Chinese. The herbal medicine is perceived by patients as a safe medication with possible minor adverse effects. 4P-1195
Prescription frequency of herbal medicines in Chinese patients with type 2 diabetes mellitus
H. Zhao 1 , Q. Chen 1 , A.-Z. Hao 2 , X.-M. Zou 2 , P. Tong 1 , J. Chan 1 , B. Tomlinson 1 . 1 Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR; 2 Chinese PLA General Hospital, China Type 2 diabetes is a major risk factor for atherosclerosis. Chinese herbal medicine has been used in correcting the multiple metabolic disorders and preventing chronic vascular complications of type 2 diabetes for thousands of years. We conducted a retrospective analysis of the prescriptions of the herbal medicines in out-patient clinics for Chinese patients with type 2 diabetes. Prescription records over the period of 1 December 1997 to 31 March 2002 at all out-patient clinics of a major medical center in Beijing were reviewed.
XIIIth International Symposium on Atherosclerosis, September 28–October 2, 2003, Kyoto, Japan
THURSDAY
Impaired creatinine clearance was associated with an increase in all cardiovascular events, except unstable angina pectoris, both before and after adjustment for other baseline risk factors (P<0.014 for all outcomes after adjustment for other risk factors). Impaired creatinine clearance was associated with a 3.3% increase in major CHD, a 4.1% increase in coronary events and a 2.2% increase in nonhaemorrhagic stroke (P<0.001 for all these events). There was no evidence of a difference in the effect of treatment with pravastatin on major cardiovascular outcomes between patients with a low creatinine clearance and patients with high creatinine clearance at baseline.
337