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N e w Patents
5110797 PEPTIDE COMPOUND AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Kazuharu Ienaga, Kunihiko Higashiura, Katoh, Japan assigned to Nippon Zoki Pharmaceutical Co Ltd Peptide compounds of formula (I): See Patent for Chemical Structure (I) wherein A is hydrogen or an amino-protecting group; X is a member selected from the group consisting of Gly, Glu, Tyr, Asp, Pbe, Ile, Ala, Pro, Leu, Hyp, Val, His, Arg, Ser, Thr, Pyr, Trp, 5-HTP, Cys, Met, tauGlu, beta-Asp; Y is a (CH2)3-6 or (CH2)3-6 having an hydroxy group; R is an hydroxy group or an oxygen atom with a carboxy-protecting group; are useful as neurotropic agents.
5110811 TRICYCLO COMPOUNDS, A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Masakun Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hirosh Hatanaka, Sakuramura, Japan assigned to Fujisawa Pharmaceutical Company Ltd This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: See Patent for Chemical Structure (I) to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
5110815 5-AMINO-5,6,7,8 TETRAHYDROQUINOLINES AND RELATED COMPOUNDS AND PHARMACEUTICAL USE Richard C Effland, David Fink assigned to Hoechst-Roussel Pharmaceuticals Inc
Novel 5-amino-5,6,7,8 tetrahydroquinolines and related compounds, intermediates and processes for the preparation thereof, and methods for relieving memory dysfunction utilizing compounds or compositions thereof are disclosed.
5169627 ORAL PHARMACEUTICAL COMPOSITION CONTAINING A POLYETHYLENE GLYCOLIMMUNOGLOBULIN G CONJUGATE FOR RECONSTITUTION OF SECRETORY IMMUNITY AND METHOD OF RECONSTITUTING SECRETORY IMMUNITY Charlotte Cunningham-Rundles assigned to Mount Sinai School of Medicine of the City University of New York Polyethylene glycol serum immunoglobulin conjugates exhibit substantial resistance to degradation by intestinal enzyme while retaining their immuno-activity. Thus, PEG-IgG or PEG-IgA conjugates can be used as orally administered therapeutics to treat patients with gastrointestinal immunodeficiency to reconstitute secretory immunity. Preferred conjugates are made by reacting activated PEG and IgG in ratios of from 1:5 to 1:1000 such that less than about 27% of the IgG lysine residues are bonded to the PEG. The conjugates are advantageously formulated into a pharmaceutical composition comprising the conjugate and a pharmaceutically acceptable oral carrier. Particularly for administration to infants, a preferred oral carder is milk.
5169634 PHARMACEUTICAL DOSAGE FORM FOR THE MEDICATION OF FISH Odd Ellingsen, Kjell Nordby, Knut Rasmussen, Trollasen, Norway assigned to Apothe Kernes Laboratorium A S A pharmaceutical dosage form for administration of medicament to fish has an outer layer of animal or vegetable material surrounding at least one inner chamber containing one or more biologically active agents. The outer layer, which is composed of animal and/or vegetable material