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5407795 CMV probes for use in solution phase sandwich
PATENT ABSTRACTS
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5407578 WASTE WATER TREATMENT PROCESS Nathwani Surendra Hemel Hempstead, UNITED KINGDOM Assigned to Klargester Environmental Engineering Limited PCT No. PCT/GB91/02172 Sec. 371 Date Jun. 7, 1993 Sec. 102(e) Date Jun. 7, 1993 PCT Filed Dec. 6, 1991 PCT Pub. No. WO92/10431 PCT Pub. Date Jun. 25, 1992. Waste water containing biodegradable matter is fed to a rotating biological contactor (RBC) (15) from an inlet tank (10) and is discharged from the RBC-containing chamber into a humus tank (21). The RBC is divided into separated upstream (15A) and downstream (15B) sections, the chamber (17) containing the downstream section being fed with water to be processed at a controlled rate from the chamber (16) containing the upstream section. A balancing chamber, for isolating the downstream section of the RBC from variations in flow of waste water to the inlet tank (10), includes the upstream section (15A, 16) of the RBC which can act sacrificially in respect of toxic incursions in the waste water.
5407795 CMV PROBES FOR USE IN SOLUTION PHASE SANDWICH Kolberg Janice A; Shen Lu-Ping; Urdea Michael S Hercules, CA, UNITED STATES Assigned to Chiron Corporation Novel DNA probe sequences for detection of CMV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified. 5407796 CYSTIC FIBROSIS MUTATION CLUSTER Cutting Garry R; Antonarakis Stylianos E; Kazazian Haig H Towson, MD, UNITED STATES Assigned to The Johns Hopkins University
Four mutations have been found clustered in exon 11 of the CFTR (cystic fibrosis transmembrane conductance regulator) gene. These mutations occur within a set of amino acids highly conserved among ATP-dependent transport proteins. Humans can be tested to determine whether they carry one of these mutations using a number of methods and/or probes taught herein. Specifically the mutations include: Asn549, Asp551, Stop553, and Thr559. 5407797 OLIGONUCLEOTIDE PROBES AND METHODS FOR DETECTING BY HYBRIDIZATION THE NUCLEIC ACIDS OF BACTERIA AND OTHER LIVING ORGANISMS Marliere Philipp; Grimont Patrick Paris, FRANCE Assigned to Institut Pasteur; Institut National de la Sante et de la Recherche Medica The invention relates to a hybridization probe for detecting the existence of bacteria in a sample. It consists of one of the two pentadecadeoxyribonucleotides of sequence (5')d AAG GAG GTG ATC CAG (3'), (5')d - CTG GAT CAC CTC CTT (3').
5407798 AMPLIFICATION OF MIDIVARIANT DNA TEMPLATES Martinelli Richard A; Donahue Jeffrey J; Unger John T Brighton, MA, UNITED STATES Assigned to Ciba Coming Diagnostics Corp New methods are provided for the amplification of a midivariant DNA containing an inserted target specific nucleic acid sequence(s) to enable detection of the presence of a target nucleic acid sequence in a test sample. One method employs midivariant DNA as a template for the synthesis of RNA catalyzed by QB replicase. Two midivariant DNA/probe conjugates including a nonreplicable portion of midivariant DNA and a target specific nucleic acid sequence (probe) are described. An amplification method including the steps of hybridization and ligation of the midivariant DNAJprobe conjugates followed by replication of the DNA template has enabled detection of less than 200 template molecules. In a
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5407578 WASTE WATER TREATMENT PROCESS Nathwani Surendra Hemel Hempstead, UNITED KINGDOM Assigned to Klargester Environmental Engineering Limited PCT No. PCT/GB91/02172 Sec. 371 Date Jun. 7, 1993 Sec. 102(e) Date Jun. 7, 1993 PCT Filed Dec. 6, 1991 PCT Pub. No. WO92/10431 PCT Pub. Date Jun. 25, 1992. Waste water containing biodegradable matter is fed to a rotating biological contactor (RBC) (15) from an inlet tank (10) and is discharged from the RBC-containing chamber into a humus tank (21). The RBC is divided into separated upstream (15A) and downstream (15B) sections, the chamber (17) containing the downstream section being fed with water to be processed at a controlled rate from the chamber (16) containing the upstream section. A balancing chamber, for isolating the downstream section of the RBC from variations in flow of waste water to the inlet tank (10), includes the upstream section (15A, 16) of the RBC which can act sacrificially in respect of toxic incursions in the waste water.
5407795 CMV PROBES FOR USE IN SOLUTION PHASE SANDWICH Kolberg Janice A; Shen Lu-Ping; Urdea Michael S Hercules, CA, UNITED STATES Assigned to Chiron Corporation Novel DNA probe sequences for detection of CMV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified. 5407796 CYSTIC FIBROSIS MUTATION CLUSTER Cutting Garry R; Antonarakis Stylianos E; Kazazian Haig H Towson, MD, UNITED STATES Assigned to The Johns Hopkins University
Four mutations have been found clustered in exon 11 of the CFTR (cystic fibrosis transmembrane conductance regulator) gene. These mutations occur within a set of amino acids highly conserved among ATP-dependent transport proteins. Humans can be tested to determine whether they carry one of these mutations using a number of methods and/or probes taught herein. Specifically the mutations include: Asn549, Asp551, Stop553, and Thr559. 5407797 OLIGONUCLEOTIDE PROBES AND METHODS FOR DETECTING BY HYBRIDIZATION THE NUCLEIC ACIDS OF BACTERIA AND OTHER LIVING ORGANISMS Marliere Philipp; Grimont Patrick Paris, FRANCE Assigned to Institut Pasteur; Institut National de la Sante et de la Recherche Medica The invention relates to a hybridization probe for detecting the existence of bacteria in a sample. It consists of one of the two pentadecadeoxyribonucleotides of sequence (5')d AAG GAG GTG ATC CAG (3'), (5')d - CTG GAT CAC CTC CTT (3').
5407798 AMPLIFICATION OF MIDIVARIANT DNA TEMPLATES Martinelli Richard A; Donahue Jeffrey J; Unger John T Brighton, MA, UNITED STATES Assigned to Ciba Coming Diagnostics Corp New methods are provided for the amplification of a midivariant DNA containing an inserted target specific nucleic acid sequence(s) to enable detection of the presence of a target nucleic acid sequence in a test sample. One method employs midivariant DNA as a template for the synthesis of RNA catalyzed by QB replicase. Two midivariant DNA/probe conjugates including a nonreplicable portion of midivariant DNA and a target specific nucleic acid sequence (probe) are described. An amplification method including the steps of hybridization and ligation of the midivariant DNAJprobe conjugates followed by replication of the DNA template has enabled detection of less than 200 template molecules. In a