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5423817 Intervertebral fusing device
IV
PatentsALERT
PCT No. PCT/AU90/00001 Sec. 371 Date Aug. 29, 1991 Sec. 102(e) Date Aug. 29, 1991 PCT Filed Jan. 9, 1990 PCT Pub. No. WO90/08188 PCT Pub. Date Jul. 26, 1990. The present invention relates generally to the isolation of leukaemia inhibitory factor (LIF) genes from livestock species, the expression of said genes in recombinant vectors and the isolation of the recombinant LIF molecules and the use of livestock species LIF to enhance the in vitro development of an embryo to the implantation stage.
5421816 ULTRASONIC TRANSDERMAL DRUG DELIVERY SYSTEM Bellevue, WA, Lipkovker Lev M STATES Assigned to Endodermic Technologies Company
UNITED Medical
Ultrasonic energy is used to release a stored drug and forcibly move the drug through the skin of an organism into the blood stream. A housing (81) includes a cavity (67) defined by an assembly of ultrasonic transducers (65) and separated from the skin by a polymeric membrane (69) that stores the drug to be delivered. The ultrasonic transducer assembly includes a flat, circular ultrasonic transducer (85) that defines the top of a truncated cone and a plurality of transducer segments (87a, 87b, 87c, 87d . . . ) that define the walls of the cone. The resonant frequency of the planar transducer is lower than the resonant frequency of the transducer segments. The planar, flat, circular transducer generates fixed frequency (5 KHz-l MHz for a impulses ultrasonic stimuli range) predetermined period of time (lo-20 seconds). Between the stimuli pulse periods, the transducer segments receive variable frequency ultrasonic pumping pulses. Preferably, the variable frequency ultrasonic oumoine oulses lie in the 50 MHz-300 MHz range. -?-he’bariable frequency ultrasonic pumping pulses are applied to opposed transducer segments. The transducer segments create beams that impinge on the skin at an oblique angle and create a pulsating wave. Further, the variable frequency ultrasonic pumping pulses are applied to opposing transducer segments in a rotating manner to create pulsating waves in the skin in a variety of directions. The stimuli pulses cause the planar transducer to produce an ultrasonic wave that excites the local nerves in the way that trauma (heat, force) excites the local nerves. The nerve excitation opens the epidermabderrnal junction membrane and the capillary endothelial cell joints. The variable frequency ultrasonic pumping pulses cause the transducer segments to produce ultrasonic waves in both the polymeric membrane and the skin. The ultrasonic waves pump the drug first through the polymeric membrane and then through, skin openings into the underlying blood vessels.
5423778 SYSTEM AND METHOD FOR TRANSPLANTATION OF CELLS Eriksson Elof; Vogt Peter M Wellesley Hills, MA, UNITED STATES Assigned to Eriksson Elof Gene transfer of genetic material with viral vectors or plasmid, in combination with a wound treatment especially those chamber, into keratinocytes, including a high percentage of epidermal stem cells, has been demonstrated to be particularly effective as a means of implanting genetically engineered cells and obtaining long term survival. By employing the wound chamber system, direct in vivo gene transfer can also be done to exposed cells in an open wound. Skin stem cells which are located in the hair follicles are used to greatly enhance long term survival. The use of the wound chamber system for gene transfer also allows non-invasive assessment of the success of transfer by assaying for the presence of the expressed protein in wound fluid, in contrast to the prior art use of invasive techniques, such as biopsies, in order to achieve the same assessment of early expression. A wide variety of proteins and materials can be expressed, either for secretion into the general blood and lymphatic system, or to alter the properties of the protein, for example, to not express proteins eliciting an irnmune response against the transplanted cell.
5423817 INTERVERTEBRAL
FUSING DEVICE
Diamond Bar, CA, 10765, UNITED Lin ChihSTATES Assigned to An intervertebral fusing device having a spring body portion interconnecting a first spiral ring mount and a second spiral ring mount. Each spiral ring mount having a spiralling projection on the outer surface. The spring body portion is defined by a plurality of spiral loops. The plurality of spiral loops and spiralling projection of the spiral ring mounts have a constant pitch. A mount cover and a head member are threaded into an internally threaded portion of a respective spiral ring mount thereby forming a chamber in which bone grafts affinitive to the cells and tissues of a vertebra may be housed. The spring body portion is similar in elasticity to the vertebra.
5424208 METHOD FOR ISOLATING CELLS FROM TISSUE WITH A COMPOSITION CONTAINING COLLAGENASE AND CHYMOPAPIN Lee Catherine T; Homacek Cynthia; Dinh Tan T Laguna Hills, CA, UNITED STATES Assigned to Baxter International Inc
PatentsALERT
PCT No. PCT/AU90/00001 Sec. 371 Date Aug. 29, 1991 Sec. 102(e) Date Aug. 29, 1991 PCT Filed Jan. 9, 1990 PCT Pub. No. WO90/08188 PCT Pub. Date Jul. 26, 1990. The present invention relates generally to the isolation of leukaemia inhibitory factor (LIF) genes from livestock species, the expression of said genes in recombinant vectors and the isolation of the recombinant LIF molecules and the use of livestock species LIF to enhance the in vitro development of an embryo to the implantation stage.
5421816 ULTRASONIC TRANSDERMAL DRUG DELIVERY SYSTEM Bellevue, WA, Lipkovker Lev M STATES Assigned to Endodermic Technologies Company
UNITED Medical
Ultrasonic energy is used to release a stored drug and forcibly move the drug through the skin of an organism into the blood stream. A housing (81) includes a cavity (67) defined by an assembly of ultrasonic transducers (65) and separated from the skin by a polymeric membrane (69) that stores the drug to be delivered. The ultrasonic transducer assembly includes a flat, circular ultrasonic transducer (85) that defines the top of a truncated cone and a plurality of transducer segments (87a, 87b, 87c, 87d . . . ) that define the walls of the cone. The resonant frequency of the planar transducer is lower than the resonant frequency of the transducer segments. The planar, flat, circular transducer generates fixed frequency (5 KHz-l MHz for a impulses ultrasonic stimuli range) predetermined period of time (lo-20 seconds). Between the stimuli pulse periods, the transducer segments receive variable frequency ultrasonic pumping pulses. Preferably, the variable frequency ultrasonic oumoine oulses lie in the 50 MHz-300 MHz range. -?-he’bariable frequency ultrasonic pumping pulses are applied to opposed transducer segments. The transducer segments create beams that impinge on the skin at an oblique angle and create a pulsating wave. Further, the variable frequency ultrasonic pumping pulses are applied to opposing transducer segments in a rotating manner to create pulsating waves in the skin in a variety of directions. The stimuli pulses cause the planar transducer to produce an ultrasonic wave that excites the local nerves in the way that trauma (heat, force) excites the local nerves. The nerve excitation opens the epidermabderrnal junction membrane and the capillary endothelial cell joints. The variable frequency ultrasonic pumping pulses cause the transducer segments to produce ultrasonic waves in both the polymeric membrane and the skin. The ultrasonic waves pump the drug first through the polymeric membrane and then through, skin openings into the underlying blood vessels.
5423778 SYSTEM AND METHOD FOR TRANSPLANTATION OF CELLS Eriksson Elof; Vogt Peter M Wellesley Hills, MA, UNITED STATES Assigned to Eriksson Elof Gene transfer of genetic material with viral vectors or plasmid, in combination with a wound treatment especially those chamber, into keratinocytes, including a high percentage of epidermal stem cells, has been demonstrated to be particularly effective as a means of implanting genetically engineered cells and obtaining long term survival. By employing the wound chamber system, direct in vivo gene transfer can also be done to exposed cells in an open wound. Skin stem cells which are located in the hair follicles are used to greatly enhance long term survival. The use of the wound chamber system for gene transfer also allows non-invasive assessment of the success of transfer by assaying for the presence of the expressed protein in wound fluid, in contrast to the prior art use of invasive techniques, such as biopsies, in order to achieve the same assessment of early expression. A wide variety of proteins and materials can be expressed, either for secretion into the general blood and lymphatic system, or to alter the properties of the protein, for example, to not express proteins eliciting an irnmune response against the transplanted cell.
5423817 INTERVERTEBRAL
FUSING DEVICE
Diamond Bar, CA, 10765, UNITED Lin ChihSTATES Assigned to An intervertebral fusing device having a spring body portion interconnecting a first spiral ring mount and a second spiral ring mount. Each spiral ring mount having a spiralling projection on the outer surface. The spring body portion is defined by a plurality of spiral loops. The plurality of spiral loops and spiralling projection of the spiral ring mounts have a constant pitch. A mount cover and a head member are threaded into an internally threaded portion of a respective spiral ring mount thereby forming a chamber in which bone grafts affinitive to the cells and tissues of a vertebra may be housed. The spring body portion is similar in elasticity to the vertebra.
5424208 METHOD FOR ISOLATING CELLS FROM TISSUE WITH A COMPOSITION CONTAINING COLLAGENASE AND CHYMOPAPIN Lee Catherine T; Homacek Cynthia; Dinh Tan T Laguna Hills, CA, UNITED STATES Assigned to Baxter International Inc