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5585351 T-cadherin adhesion molecule
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PATENT ABSTRACTS
transcript is either differentially spliced, alternatively spliced, incompletely spliced, or unspliced. Also disclosed is a recombinant attenuated HIV containing only structural proteins gag, pol, and env, wherein the expression of the structural proteins is rev-independent and facilitated by the constitutive transport enhancer.
5585345 CTP E X T E N D E D F O R M OF GLYCOPROTEIN HORMONES Boime Irving St Louis, MO, UNITED STATES Assigned to Washington University Extended forms of beta subunits of human glycoproteins wherein the amino acid sequence of a carboxy terminal peptide (CTP) representing positions from about 112-118 to 145 of the human CG-beta subunit or a variant form thereof is appended to the C-terminus are disclosed. Recombinant materials for the production of these extended human glycoprotein beta subunits and production of the modified hormones containing the extended beta subunits are also described. Pharmaceutical compositions containing the modified forms of these hormones are useful in pharmacological applications analogous to those of the unmodified forms.
5585350 THROMBIN-INHIBITORY PROTEIN F R O M TICKS Friedrich Thomas; Koerwer Wolfgang; Kroeger Burkhard; Bialojan Siegfried Darmstadt, GERMANY Assigned to BASF Aktiengesellschaft PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993. A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial ami n o acid sequences Val-Ala-Lys -Phe-Ala-X-Asn-Ser-Gly-Ser-GluThr-Gly, His-Ala-Y-Phe-Glu, Arg-Val-Ser-AspPhe-Glu, Pbe-Val-Tyr-Thr-Ile-Glu, where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.
5585351
5585346 PEPTIDE DERIVATIVES OF C Y T O C H R O M E B558 A N D THEIR USE AS M E D I C A M E N T S Malech Harry L; Lomax Karen J; Rotrosen Daniel; Nunoi Hiroyuki Bethesda, MD, UNITED STATES Assigned to The United States of America as represented by the Department of Health and Human Services Peptide derivatives with inhibitory activity on the enzyme systems involved in the oxidative burst of human phagocytic cells comprise a certain sequence of a number of carboxyl-terminal amino acids of human cytochrome b558. The derivatives may be used in medicaments for the treatment of inflammatory diseases.
T-CADHERIN A D H E S I O N MOLECULE Ranscht Barbara De1 Mar, CA, UNITED STATES Assigned to La Jolla Cancer Research Foundation The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadberin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of detecting tumor growth which consists of inhibiting the activity of T-cadherin in a tumor. A method of effecting traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.
PATENT ABSTRACTS
transcript is either differentially spliced, alternatively spliced, incompletely spliced, or unspliced. Also disclosed is a recombinant attenuated HIV containing only structural proteins gag, pol, and env, wherein the expression of the structural proteins is rev-independent and facilitated by the constitutive transport enhancer.
5585345 CTP E X T E N D E D F O R M OF GLYCOPROTEIN HORMONES Boime Irving St Louis, MO, UNITED STATES Assigned to Washington University Extended forms of beta subunits of human glycoproteins wherein the amino acid sequence of a carboxy terminal peptide (CTP) representing positions from about 112-118 to 145 of the human CG-beta subunit or a variant form thereof is appended to the C-terminus are disclosed. Recombinant materials for the production of these extended human glycoprotein beta subunits and production of the modified hormones containing the extended beta subunits are also described. Pharmaceutical compositions containing the modified forms of these hormones are useful in pharmacological applications analogous to those of the unmodified forms.
5585350 THROMBIN-INHIBITORY PROTEIN F R O M TICKS Friedrich Thomas; Koerwer Wolfgang; Kroeger Burkhard; Bialojan Siegfried Darmstadt, GERMANY Assigned to BASF Aktiengesellschaft PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993. A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial ami n o acid sequences Val-Ala-Lys -Phe-Ala-X-Asn-Ser-Gly-Ser-GluThr-Gly, His-Ala-Y-Phe-Glu, Arg-Val-Ser-AspPhe-Glu, Pbe-Val-Tyr-Thr-Ile-Glu, where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.
5585351
5585346 PEPTIDE DERIVATIVES OF C Y T O C H R O M E B558 A N D THEIR USE AS M E D I C A M E N T S Malech Harry L; Lomax Karen J; Rotrosen Daniel; Nunoi Hiroyuki Bethesda, MD, UNITED STATES Assigned to The United States of America as represented by the Department of Health and Human Services Peptide derivatives with inhibitory activity on the enzyme systems involved in the oxidative burst of human phagocytic cells comprise a certain sequence of a number of carboxyl-terminal amino acids of human cytochrome b558. The derivatives may be used in medicaments for the treatment of inflammatory diseases.
T-CADHERIN A D H E S I O N MOLECULE Ranscht Barbara De1 Mar, CA, UNITED STATES Assigned to La Jolla Cancer Research Foundation The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadberin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of detecting tumor growth which consists of inhibiting the activity of T-cadherin in a tumor. A method of effecting traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.