741. Delivery of Human Tissue Kallikrein Gene Mediates Reductions in Blood Pressure and the Levels of Plasma Insulin and Blood Glucose in Fructose-Induced Hypertensive Rats with Diabetes

   E                (C@ 0

     ''.%CA    

            

    0    

                - /       

741. Delivery of Human Tissue Kallikrein Gene Mediates Reductions in Blood Pressure and the Levels of Plasma Insulin and Blood Glucose in Fructose-Induced Hypertensive Rats with Diabetes Tao Wang,1 Chunxia Zhao,1 Peihua Wang,1 Dao Wen Wang,1 Xiao Xiao,1,2 Lee Chao.3 1 Department of Internal Medicine and Gene Therapy Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 3Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States. )E  7                  

                       C               

                

 

               

             " 

           #   7 #  (  "$     

   "   -89H/            ! $*'=8        $*' -CA/ -8    

  /  

      " 

      -MB/   , 

               E 

     -MB/            

 

 

   & 

        

      

                        E     

    @ 7 ' 

   E   $*'"CA 

   

         =    E        

  = 

 -? 8/ '        

           -   CA"   869±=&= %D  5B6±,B= %D/    - CA" B:=±,B%D6==±8& % D O998/  



        CA" 

            

   89H      2            

 

          E   3        

       0   2            >D('    $*'" CA  

  7                      

                              " 

                          CA              

742. A New Model of Autosomal Dominant Polycystic Kidney Disease: Overexpression of a Human PKD2 Transgene in Mice Stephane J. Burtey,1 Philippe Pautre,1 Yvon Berland,2,3 Michel Fontes.1 1 U491, INSERM, Marseille, France; 2Service de Néphrologie, APHM, Marseille, France; 3Centre d′Investigation Clinique, INSERM/APHM, Marseille, France. '         -'$!A$/     

             8  :99    '$!A$     G

           

                 ->(@$/  



    '$!A$     &H  >(@$        /?.'   

:&H'$!A$ 

8B8==    6=9=        " 8 -!8/    !8    !8        -                   0/ !8             " 3   "      ,&99    3     /?.,           '$!A$  

  61,8",=      5B:               , -!,/   B    "        *C,   ))C   !,               !8   !,                 

       /?.' /?.,  '$!A$         /0'   /0, " 

              /0'           /0,  G          /0'   /0, 

 "               G 

 

        /0' "%"     /0' J%"                  ?  /0,  ′   

     /0, -/     /0, "%    

 

     -              /     '$!A$            2     3   /?.'       

        /?.'            4          !' -!8     / 

               !,                                  '$!A$   

          '$!A$          3     /?.'   !,           3   /?.,

       

 )                      0               0

          /?.,      0  E 

  2' -      /    /?.,     2'  8:&A0 

       

   

                    2'               /?.,    0  



                              3           /?.,            !        0                       0  

                     )    '$!A$    

                      

            /0, A)                 

        '$!A$

0    

                - /        Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

S243