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91288318 Influence of the antioestrogen tamoxifen on normal breast tissue
249 91288099 Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women Notelovitz M.; Martin D.; Tesar R.; Khan F.Y.; Probart C.; Fields C.; McKenzie L. Center for Climacteric Studies, 222 SW 36th Terrace. Gainesville. FL 32607 J. BONE MINER.
RES.
1991 616 (583-590)
This study was undertaken to examine the effect of estrogen replacement therapy alone and estrogen replacement therapy plus variable-resistance weight training on the bone mineral content of surgically menopausal women. A total of 20 surgically menopausal women were randomized and treated with either 0.625 mg conjugated estrogen daily or the same dose of estrogen plus a closely monitored exercise program involving the use of Nautilus muscle strengtheningiendurance equipment. After I year’s observation, the bone mineral density (BMD) of the spine determined by dual-photon absorptiometry increased m the exercising subjects by 8.3 f 5.3% (p = 0.004). 95% confidence limits (CL) 3.9-12.8%; with estrogen replacement therapy alone maintained their BMD: 1.5 f 12.4% (p = CL = -6.9-9.8s). The total body BMD of the exercising group increased by 2.1 f 1.5% (p = CL = 0.8-3.3X): the nonexercising women had a nonsignificant 0.6 f 2.9% change (p =
the group 0.36; 95’!4) 0.003: 95’%~ 0.30; 95’“;)
CL = -1.4-2.5%). A significant increase of 4.1 f 4.3%~ (p = 0.01; 95% CL = 0.8-7.4%) in the radial midshaft BMD of the exercising group was found; the estrogen alone group recorded a nonsignificant change of -0.3 f 3. I% (p = 0.33; 95% CL = -1.7-2.4%). The results of this study suggest that variable-resistance training in estrogen-replete women adds bone to both the axial and appendicular skeleton. 91288318 Influence of the antioestrogen tamoxifen on normal breast tissue Walker K.J.; Price-Thomas J.M.; Candlish W.: Nicholson R.I. Tenovus Institute for Cancer Research, University of Wales College of Medicine. Heath Park, Card(fl CF4 4xx BR. J. CANCER
1991 6414 (764-768)
Immunohistochemical assays have been employed to study the expression of ER, PgR, EGFR and Ki67 immunostaining in normal breast tissue (n = 76). The expression of ER and PgR was highly variable in both pre and postmenopausal women and was characlerised by large numbers of apparently negative cells. This was most evident for ER-ICA staining in tissues removed from premenopausal women. PgR levels were highest in the ducts of premenopausal women, while EGFR expression was elevated in both ducts and lobules. Ki,, expression was observed in < 10% of all normal cells and was suppressed by the menopause in lobular tissue. Tamoxifen therapy (40 mg d-‘) did not influence the expression of PgR, EGFR or Ki,, immunostaining in cancer associated normal tissue (n = 17). A significant increase, however, was observed in the mean percentage ER positivity in ductal tissue. No effect of duration of tamoxifen therapy
was observed
on the expression
of the antigens
studied.
91288901 The prevention of corticosteroid-induced osteoporosis with nandrolone decanoate Adami S.; Fossaluzza V.: Rossini M.; Bertoldo F.; Gatti D.: Zamberlan N.: Lo Cascio Istituto di Semeiotica c Nefrologia Medica, Policlinico. 37134 Verona BONE MINER. 1991 1511 (72-81)
V
The effects of nandrolone decanoate (ND; 50 mg IM every three weeks) on calcium metabolism and forearm bone density were studied in a randomized trial in 35 women receiving long-term therapy with corticosteroids (CST) for rheumatic disease. The 17 patients who served as controls were on CST therapy for less years and their bone density was higher. Thus a second control group, pair-matched with the active treatment group for age, duration of CST therapy and bone density, was selected retrospectively. At the end of the 18 months’ treatment course with ND, forearm bone density was increased by 5.1% (P < 0.01) but fell by I I .3% (P < 0.01) and 6.7% respectively in the first and second control group. The patients on ND differed significantly from both control groups in the changes at 6, 12 and 18 months (P < 0.01).
RES.
1991 616 (583-590)
This study was undertaken to examine the effect of estrogen replacement therapy alone and estrogen replacement therapy plus variable-resistance weight training on the bone mineral content of surgically menopausal women. A total of 20 surgically menopausal women were randomized and treated with either 0.625 mg conjugated estrogen daily or the same dose of estrogen plus a closely monitored exercise program involving the use of Nautilus muscle strengtheningiendurance equipment. After I year’s observation, the bone mineral density (BMD) of the spine determined by dual-photon absorptiometry increased m the exercising subjects by 8.3 f 5.3% (p = 0.004). 95% confidence limits (CL) 3.9-12.8%; with estrogen replacement therapy alone maintained their BMD: 1.5 f 12.4% (p = CL = -6.9-9.8s). The total body BMD of the exercising group increased by 2.1 f 1.5% (p = CL = 0.8-3.3X): the nonexercising women had a nonsignificant 0.6 f 2.9% change (p =
the group 0.36; 95’!4) 0.003: 95’%~ 0.30; 95’“;)
CL = -1.4-2.5%). A significant increase of 4.1 f 4.3%~ (p = 0.01; 95% CL = 0.8-7.4%) in the radial midshaft BMD of the exercising group was found; the estrogen alone group recorded a nonsignificant change of -0.3 f 3. I% (p = 0.33; 95% CL = -1.7-2.4%). The results of this study suggest that variable-resistance training in estrogen-replete women adds bone to both the axial and appendicular skeleton. 91288318 Influence of the antioestrogen tamoxifen on normal breast tissue Walker K.J.; Price-Thomas J.M.; Candlish W.: Nicholson R.I. Tenovus Institute for Cancer Research, University of Wales College of Medicine. Heath Park, Card(fl CF4 4xx BR. J. CANCER
1991 6414 (764-768)
Immunohistochemical assays have been employed to study the expression of ER, PgR, EGFR and Ki67 immunostaining in normal breast tissue (n = 76). The expression of ER and PgR was highly variable in both pre and postmenopausal women and was characlerised by large numbers of apparently negative cells. This was most evident for ER-ICA staining in tissues removed from premenopausal women. PgR levels were highest in the ducts of premenopausal women, while EGFR expression was elevated in both ducts and lobules. Ki,, expression was observed in < 10% of all normal cells and was suppressed by the menopause in lobular tissue. Tamoxifen therapy (40 mg d-‘) did not influence the expression of PgR, EGFR or Ki,, immunostaining in cancer associated normal tissue (n = 17). A significant increase, however, was observed in the mean percentage ER positivity in ductal tissue. No effect of duration of tamoxifen therapy
was observed
on the expression
of the antigens
studied.
91288901 The prevention of corticosteroid-induced osteoporosis with nandrolone decanoate Adami S.; Fossaluzza V.: Rossini M.; Bertoldo F.; Gatti D.: Zamberlan N.: Lo Cascio Istituto di Semeiotica c Nefrologia Medica, Policlinico. 37134 Verona BONE MINER. 1991 1511 (72-81)
V
The effects of nandrolone decanoate (ND; 50 mg IM every three weeks) on calcium metabolism and forearm bone density were studied in a randomized trial in 35 women receiving long-term therapy with corticosteroids (CST) for rheumatic disease. The 17 patients who served as controls were on CST therapy for less years and their bone density was higher. Thus a second control group, pair-matched with the active treatment group for age, duration of CST therapy and bone density, was selected retrospectively. At the end of the 18 months’ treatment course with ND, forearm bone density was increased by 5.1% (P < 0.01) but fell by I I .3% (P < 0.01) and 6.7% respectively in the first and second control group. The patients on ND differed significantly from both control groups in the changes at 6, 12 and 18 months (P < 0.01).