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A clinicopathological study on keratocystic odontogenic tumours related to Gorlin-Goltz syndrome
150 Distraction osteogenesis for the correction of severe mandibular deficiency M.E. Ul Haq King Edward Medical University, Lahore, Pakistan Background: Distraction osteogenesis (DO) is a biologic process of new bone formation between the surfaces of bone segments that are gradually separated by incremental traction. In this research, we intended to present the treatment of patients who have severe mandibular deficiency. An intraoral monoplanar distractor was used to achieve independent horizontal distraction of the body of mandible. Amount of lengthening was determined with cephalograms and clinical observation. Moreover, alterations at the posterior airway space due to elongation of mandible was also researched. As lots of patients in Pakistan get reported for mandibular hypoplasia due to both congenital reasons and temporomandibular joint (TMJ) ankylosis, patients with such problems were included. Objective: To assess the effectiveness of monoplanar mandibular distractor by evaluating the treatment effect and one-year stability, measuring changes on the affected and non-affected sides, and evaluating correction of the occlusal plane and oral commissural cant. Methods: Study design — longitudinal interventional study. Setting — Oral and Maxillofacial Surgery Department, King Edward Medical University/Mayo Hospital Lahore. Sample size — was 15 patients meeting the inclusion criteria. Sampling technique — non-probability purposive sampling. Results: The patient’s mandible was elongated successfully. Cephalometric analysis revealed that ANB angle decreased from 13–6◦ , overjet of 15 mm decreased to 4 mm, corpus length increased from 49–67 mm. Posterior airway space also increased due to advancement of the mandible. Conclusion: Satisfactory results from both aesthetic and functional standpoints were obtained by distraction osteogenesis of the body of mandible.
there were three lesions in three patients (43%). There were four male and three female patients thus a slight male predilection. Recurrence was observed in two KCOTs which corresponded to 12%. KCOT does appear to respond successfully to marsupialisation and can resolve totally following marsupialisation often to a period of 6–12 months. Conclusion: Recurrences usually manifest within the first 5–7 years, but in our present study it was after 10 years. Persistence and recurrences occur possibly from daughter cysts around the lining. So long follow-up periods are important. http://dx.doi.org/10.1016/j.ijom.2017.02.518 The role of microorganisms in medication-related osteonecrosis of the jaw, using methods to identify relevant microorganisms and treatment — a systematic literature review S¸. Urhan ∗ , S. Adilo˘glu, O.T. Köseo˘glu Hacettepe University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Turkey
M.I. Ul Khaliq
Medication-related osteonecrosis of the jaw (MRONJ) is a serious oral complication associated with antiresorptive and antiangiogenic therapies; it results in progressive bone and soft tissue destruction in the maxillofacial region. MRONJ etiopathogenesis has not been completely understood, although there are many theories trying to clarify it. Theories pointing to bone turnover and angiogenesis inhibition, and the role of microorganisms have been reported. According to previous studies Actinomyces species is the most frequent microorganism found in MRONJ lesions. There are many other bacterial and fungal species that are also found in the affected bone and can cause bone destruction through various direct and indirect mechanisms. These conditionally pathogenic oral microorganisms were identified in these patients using real-time polymerase chain reaction in saliva, wound and bone samples, direct visualisation methods with advanced microscopy or DNA- and RNA-based techniques and traditional culturing and antibiotic sensitivity testing studies. The objective of the study is to present a literature review focusing on the role of microorganisms in MRONJ developments, methods to identify relevant microorganisms and the treatment of the infections that are caused by these microorganisms.
Government Dental College and Hospital, Srinagar, India
http://dx.doi.org/10.1016/j.ijom.2017.02.519
Background and Objectives: To assess clinicopathological features and recurrence rate after treatment of keratocystic odontogenic tumour (KCOT) related to Gorlin-Goltz syndrome in our institution from 2004 to 2014. Methods: The 17 KCOTs related to Gorlin-Goltz syndrome in 7 patients were assessed for age, gender, number of KCOT, location, size, signs, symptoms, radiographic features, treatment and recurrence rate. Findings: All patients presented multiple KCOT, 13 (77%) lesions were located in mandible and 4 (23%) in maxilla — so most involving mandible. Most of the tumours presented a unilocular pattern (71%) and had tooth association (88%). Four patients (57%) were in age group of 10–19 years and three patients (43%) were in age group of 20–29 years. The peak prevalence was in second and third decades of life. The four patients had two lesions (57%) and
Mandibular osteomyelitis in SAPHO syndrome, is surgery necessary? A four cases report and literature review
http://dx.doi.org/10.1016/j.ijom.2017.02.517 A clinicopathological study on keratocystic odontogenic tumours related to Gorlin-Goltz syndrome
M. Wang ∗ , C. Li, J.Z. Zhao, W. Zhang Peking Union Medical College Hospital, Beijing, China Background: The treatment of mandible lesions in synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) has not been concluded, and surgical interventions like partial or radical dissection are controversial. Objectives: To find clinical features and surgical prognosis of mandibular osteomyelitis in SAPHO syndrome, and introduce a combination therapy regimen of corticosteroids, Tripterygium wilfordii Hook F (TwHF) and minocycline for SAPHO treatment.
there were three lesions in three patients (43%). There were four male and three female patients thus a slight male predilection. Recurrence was observed in two KCOTs which corresponded to 12%. KCOT does appear to respond successfully to marsupialisation and can resolve totally following marsupialisation often to a period of 6–12 months. Conclusion: Recurrences usually manifest within the first 5–7 years, but in our present study it was after 10 years. Persistence and recurrences occur possibly from daughter cysts around the lining. So long follow-up periods are important. http://dx.doi.org/10.1016/j.ijom.2017.02.518 The role of microorganisms in medication-related osteonecrosis of the jaw, using methods to identify relevant microorganisms and treatment — a systematic literature review S¸. Urhan ∗ , S. Adilo˘glu, O.T. Köseo˘glu Hacettepe University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Turkey
M.I. Ul Khaliq
Medication-related osteonecrosis of the jaw (MRONJ) is a serious oral complication associated with antiresorptive and antiangiogenic therapies; it results in progressive bone and soft tissue destruction in the maxillofacial region. MRONJ etiopathogenesis has not been completely understood, although there are many theories trying to clarify it. Theories pointing to bone turnover and angiogenesis inhibition, and the role of microorganisms have been reported. According to previous studies Actinomyces species is the most frequent microorganism found in MRONJ lesions. There are many other bacterial and fungal species that are also found in the affected bone and can cause bone destruction through various direct and indirect mechanisms. These conditionally pathogenic oral microorganisms were identified in these patients using real-time polymerase chain reaction in saliva, wound and bone samples, direct visualisation methods with advanced microscopy or DNA- and RNA-based techniques and traditional culturing and antibiotic sensitivity testing studies. The objective of the study is to present a literature review focusing on the role of microorganisms in MRONJ developments, methods to identify relevant microorganisms and the treatment of the infections that are caused by these microorganisms.
Government Dental College and Hospital, Srinagar, India
http://dx.doi.org/10.1016/j.ijom.2017.02.519
Background and Objectives: To assess clinicopathological features and recurrence rate after treatment of keratocystic odontogenic tumour (KCOT) related to Gorlin-Goltz syndrome in our institution from 2004 to 2014. Methods: The 17 KCOTs related to Gorlin-Goltz syndrome in 7 patients were assessed for age, gender, number of KCOT, location, size, signs, symptoms, radiographic features, treatment and recurrence rate. Findings: All patients presented multiple KCOT, 13 (77%) lesions were located in mandible and 4 (23%) in maxilla — so most involving mandible. Most of the tumours presented a unilocular pattern (71%) and had tooth association (88%). Four patients (57%) were in age group of 10–19 years and three patients (43%) were in age group of 20–29 years. The peak prevalence was in second and third decades of life. The four patients had two lesions (57%) and
Mandibular osteomyelitis in SAPHO syndrome, is surgery necessary? A four cases report and literature review
http://dx.doi.org/10.1016/j.ijom.2017.02.517 A clinicopathological study on keratocystic odontogenic tumours related to Gorlin-Goltz syndrome
M. Wang ∗ , C. Li, J.Z. Zhao, W. Zhang Peking Union Medical College Hospital, Beijing, China Background: The treatment of mandible lesions in synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) has not been concluded, and surgical interventions like partial or radical dissection are controversial. Objectives: To find clinical features and surgical prognosis of mandibular osteomyelitis in SAPHO syndrome, and introduce a combination therapy regimen of corticosteroids, Tripterygium wilfordii Hook F (TwHF) and minocycline for SAPHO treatment.