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A clinicoradiologic study of hypertrophic olivary degeneration
Abstracts / Parkinsonism and Related Disorders 22 (2016) e87ee141
neurological copper disorders. Lancet Neurol 2015;14:103-113. 3. Gerber PE, Lynd LD. Selective serotonin-reuptake inhibitor-induced movement disorders. Ann Pharmacother 1998;32:692-698. 4. Leo RJ. Movement disorders associated with the serotonin selective reuptake inhibitors. J Clin Psychiatry 1996;57:449-454. 5. Fonseca L, Rodrigues M, Machado A. Psychogenic movement disorder after a venlafaxine-induced dystonia. Mov Disord 2010;25:506-507. P 3.086. A CLINICORADIOLOGIC DEGENERATION
STUDY
OF
HYPERTROPHIC
OLIVARY
Takuya Konno 1, Audrey Strongosky 1, Daniel Broderick 2, Zbigniew Wszolek 1. 1 Department of Neurology, Mayo Clinic Florida, Jacksonville, United States; 2 Department of Radiology, Mayo Clinic Florida, Jacksonville, United States Objectives: To study the frequency and causation of hypertrophic olivary degeneration (HOD) reported in a radiologic database of the Mayo Clinic Florida and Arizona. HOD usually occurs following lesions involving the dento-rubro-olivary pathway. There are two types of HOD, unilateral and bilateral. Current literature suggests bilateral HOD is less frequent. The epidemiology and etiology of HOD are unknown, particularly bilateral HOD. Methods: We performed a search of the Mayo Clinic radiologic report database, using the terms “hypertrophic olivary degeneration”, “HOD” and “olivary”. Pertinent medical records and MR brain exams for the matches generated were reviewed. Results: We identified 142 MRI studies on 95 cases with radiologically proven HOD, 39 cases with unilateral HOD and 56 with bilateral. Cerebrovascular diseases are the most frequent etiology in both type of HOD: 57% (n¼22) in unilateral and 31% (n¼18) in bilateral. Unknown etiology was present more frequently in cases with bilateral HOD than unilateral HOD: 52% (n¼29) vs. 15% (n¼6) (c2 test, p<0.001). In unilateral cases, there was a correlation between the side of the HOD and causative lesion. While the lesions of unilateral HOD had a tendency to improve radiologically with time, that of bilateral HOD were likely to worse (c2 test, p<0.05). Conclusions: Our study showed bilateral HOD is more common than expected. A half of bilateral HOD cases had no obvious causes and some of them worsen over time; this may implicate a possible primary neurodegenerative process.
e141
P 3.087. INTEROCEPTIVE AWARENESS IN PATIENTS WITH FUNCTIONAL MOTOR DISORDERS Benedetta Demartini 1, Lucia Ricciardi 2, Laura Crucianelli 3, Charlotte 4, Mark J. Edwards 2, AIkaterini Photopoulou 5. 1 Cattedra di Krahe degli Studi di Psichiatria, Dipartimento di Scienze della Salute, Universita Milano, Italy, Milano, Italy; 2 Sobell Department, UCL Institute of Neurology, Queen Square, London, United Kingdom; 3 Department of Psychology, University of Hertfordshire, London, United Kingdom; 4 Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; 5 Division of Psychology and Language Sciences, CEHP Research Department, University College London, London, United Kingdom Objectives: historically, emotional factors, such as trauma or psychological conflict, have been suggested as causal factors of functional motor disorders (FMD). More recent approaches have instead stressed potential neural and cognitive abnormalities in the allocation and maintenance of attention. Given the proposed important role of interoception for emotion, aim of our study was to explore whether patients with FMD have altered interoceptive awareness in relation to controls, as measured ‘objectively’ with the heartbeat detection task. Methods: in the current study, we compared the interoceptive awareness of a group of individuals with FMD (N ¼ 16) with a group of healthy controls (N ¼17). We employed a commonly used heartbeat detection task which tracks the level of concordance between one’s heart rate and its subjective perception, as a proxy for interoceptive awareness more generally. Results: we found that FMD patients have lower interoceptive accuracy than healthy subjects, and such reduced interoceptive accuracy was predictive of their depressive symptoms, as well as their tendency to focus on the external features of their body (self-objectification). Contrary to our predictions, interoceptive accuracy was not predictive of alexithymia. Conclusions: these results suggest a potential trade-off between the allocation of attention to internal versus external aspects of the body in FMD. References: 1. Edwards MJ, Fotopoulou A. Parees I. Neurobiology of functional (psychogenic) movement disorders. Curr Opin Neurol 2013;26:442e447. 2. Schandry R. Heart beat perception and emotional experience. Psychophysiology 1981;18:483-488.
neurological copper disorders. Lancet Neurol 2015;14:103-113. 3. Gerber PE, Lynd LD. Selective serotonin-reuptake inhibitor-induced movement disorders. Ann Pharmacother 1998;32:692-698. 4. Leo RJ. Movement disorders associated with the serotonin selective reuptake inhibitors. J Clin Psychiatry 1996;57:449-454. 5. Fonseca L, Rodrigues M, Machado A. Psychogenic movement disorder after a venlafaxine-induced dystonia. Mov Disord 2010;25:506-507. P 3.086. A CLINICORADIOLOGIC DEGENERATION
STUDY
OF
HYPERTROPHIC
OLIVARY
Takuya Konno 1, Audrey Strongosky 1, Daniel Broderick 2, Zbigniew Wszolek 1. 1 Department of Neurology, Mayo Clinic Florida, Jacksonville, United States; 2 Department of Radiology, Mayo Clinic Florida, Jacksonville, United States Objectives: To study the frequency and causation of hypertrophic olivary degeneration (HOD) reported in a radiologic database of the Mayo Clinic Florida and Arizona. HOD usually occurs following lesions involving the dento-rubro-olivary pathway. There are two types of HOD, unilateral and bilateral. Current literature suggests bilateral HOD is less frequent. The epidemiology and etiology of HOD are unknown, particularly bilateral HOD. Methods: We performed a search of the Mayo Clinic radiologic report database, using the terms “hypertrophic olivary degeneration”, “HOD” and “olivary”. Pertinent medical records and MR brain exams for the matches generated were reviewed. Results: We identified 142 MRI studies on 95 cases with radiologically proven HOD, 39 cases with unilateral HOD and 56 with bilateral. Cerebrovascular diseases are the most frequent etiology in both type of HOD: 57% (n¼22) in unilateral and 31% (n¼18) in bilateral. Unknown etiology was present more frequently in cases with bilateral HOD than unilateral HOD: 52% (n¼29) vs. 15% (n¼6) (c2 test, p<0.001). In unilateral cases, there was a correlation between the side of the HOD and causative lesion. While the lesions of unilateral HOD had a tendency to improve radiologically with time, that of bilateral HOD were likely to worse (c2 test, p<0.05). Conclusions: Our study showed bilateral HOD is more common than expected. A half of bilateral HOD cases had no obvious causes and some of them worsen over time; this may implicate a possible primary neurodegenerative process.
e141
P 3.087. INTEROCEPTIVE AWARENESS IN PATIENTS WITH FUNCTIONAL MOTOR DISORDERS Benedetta Demartini 1, Lucia Ricciardi 2, Laura Crucianelli 3, Charlotte 4, Mark J. Edwards 2, AIkaterini Photopoulou 5. 1 Cattedra di Krahe degli Studi di Psichiatria, Dipartimento di Scienze della Salute, Universita Milano, Italy, Milano, Italy; 2 Sobell Department, UCL Institute of Neurology, Queen Square, London, United Kingdom; 3 Department of Psychology, University of Hertfordshire, London, United Kingdom; 4 Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; 5 Division of Psychology and Language Sciences, CEHP Research Department, University College London, London, United Kingdom Objectives: historically, emotional factors, such as trauma or psychological conflict, have been suggested as causal factors of functional motor disorders (FMD). More recent approaches have instead stressed potential neural and cognitive abnormalities in the allocation and maintenance of attention. Given the proposed important role of interoception for emotion, aim of our study was to explore whether patients with FMD have altered interoceptive awareness in relation to controls, as measured ‘objectively’ with the heartbeat detection task. Methods: in the current study, we compared the interoceptive awareness of a group of individuals with FMD (N ¼ 16) with a group of healthy controls (N ¼17). We employed a commonly used heartbeat detection task which tracks the level of concordance between one’s heart rate and its subjective perception, as a proxy for interoceptive awareness more generally. Results: we found that FMD patients have lower interoceptive accuracy than healthy subjects, and such reduced interoceptive accuracy was predictive of their depressive symptoms, as well as their tendency to focus on the external features of their body (self-objectification). Contrary to our predictions, interoceptive accuracy was not predictive of alexithymia. Conclusions: these results suggest a potential trade-off between the allocation of attention to internal versus external aspects of the body in FMD. References: 1. Edwards MJ, Fotopoulou A. Parees I. Neurobiology of functional (psychogenic) movement disorders. Curr Opin Neurol 2013;26:442e447. 2. Schandry R. Heart beat perception and emotional experience. Psychophysiology 1981;18:483-488.