A new synthesis of pyrimidine 1-oxides1,2

~~~~~~~~~~~ Letters ~0. 37, pp 3337 - 3338, 1976. Pergamon Press. Printed in Greet Britain.

3337

No. 37

3338

In

the

of

cases

the

obtained in

the

E

and

direct

2

this new method

possibility of synthesizing

pyrimidine

which

gives yields,

of pyrimidines,

oxidation

moreover

l-oxides

this

with

are

higher

than

non-oxidative

substituents

the

method

which

ones opens

up

sensitive

are

for oxidation. Acknowledgement

1.

2.

3.

Pyrimidines

paper

Ring

Transformation

in Reactions

XIII

see

E.A.Oostveen,

in the

press.

H.C.van

der

93,

(1974).

225

5.

R.R.Schmidt,

6.

See

London

for

Tetrahedron

(IWLI); The

and

and

H.C.van

der

Letters

1972,

‘1133;

and

H.C.van

-

spectra

der

Plas,

and

H.Jongejan

“Chemistry

of

the

with

Nucleophiles XIV,

95 (1976),

Rec.TraV.Chim.Pays-Bas

B.Zuurdeeg,

Heterocyclic

for part

=

Kec.Trav.Chim.Pays-Bas

N-oxides",

Academic

Press,

333.

1972,

F.Roeterdink

Compounds

and H.Jongejan,

Plas

J.Minamikawa, Y.Miki, S.Matsugashita and

preparation: Y.Tamura,

their

and H.C.van

p.m.

1971,

Synthesis

C.A.H.Rasmussen

series

of Heterocyclic

J.M.Lagowski,

New York,

lH-NMR, IR

compounds.

these

Miss M.C.Vollering,

Plas,

A.R.Katritzky

in

submitted.

1976,

4.

7.

Previous

LVI.

Rec.Trav.Chim.Pays-Bas

and

K.Kas”ga, der

melting

Plas,

points

M.Hirobe

and T.Okamoto,

Rec.Trav.Chim.Pays-Bas, were

identical

with those

M.Ikeda,

Chem.Pharm.Bull.

2,

submitted.

of

the

authentic

1814