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A Note of Thanks
Clinical Therapeutics/Volume 38, Number 12, 2016
A NOTE OF THANKS Peer review is the lifeblood of scientific publishing. To maintain the highest standards for the content of manuscripts published in Clinical Therapeutics, we seek independent reviewers from the faculties of medical schools and schools of pharmacy worldwide. Not only are our reviewers asked to provide in-depth reviews, but they are asked to do so within a short period of time. Clinical Therapeutics wishes to thank the following individuals for sharing their time and expertise this year in our ongoing effort to strengthen the peer-review process:
Mahran S. Abdel-Rahman, PhD Ivan Adamec Mayank Ajmera Emmanuel O. Akala, RPh, PhD Muhammad Akhktar, PhD John C. Alexander, MD Badraddin M. Al-Hadiya, PhD Lamia AlHajri, PharmD Carlos Javier Almeciga-Diaz, BPharm, PhD Amy Aloysi Ragaa Hosny Mohamad Al-Tahtawy, PhD Russ B. Altman Guohua An Tracy Anderson-Haag, PharmD, BCPS Rob Arbuckle Wilbert S. Aronow, MD Rehab H. Ashour, PhD Vozikis Athanassios Adel Bachour Rajesh Balkrishnan, PhD Sid Barritt Joshua I. Barzilay, MD Biswanath Basu Marisa Battistella Tom Belhorn Roxanna M. Bendixen, PhD Bryan Bennett James Richard Berenson, MD Gaetano Bertino, MD Palash Bhattacharya, PhD John A. Bosso David W. Boulton, PhD Ghada Bourjeily Carla Boutin-Foster Eric Boyce, PharmD John Bradley Geri Brown, MD Stephen Brunton Marilyn N. Bulloch, PharmD Christopher A. Burgess Kirsten Butterfoss Franceso Cacciatore, MD, PhD Terence Campbell, MD Xiting Cao, PhD Domenico Capone Michael Carrithers, MD, PhD John A. Carter Anthony M. Casapao, PharmD Edoardo Casiglia Marco Centanni, MD Chao Chen
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Yu-Huei Cheng, PhD David Cherney Lindsey Childs-Kean, PharmD, MPH Edward John Ciaccio, PhD Alexander Thomas Cohen, MBBS, MSc, MD Stanley B. Cohen, MD Pierre Colin Ignacio Conde, MD Pio Conti Stephen Joel Coons, PhD Paolo A. Cortesi, PhD Andrew L. Coveler, MD Stephanie Crawford, PhD, MPH Andrea Cruz Natalie Cusano Joao Data-Franco Lisa E. Davis, PharmD Stacie Deiner Oscar Della Pasqua, PhD, MD Rishi J. Desai Sarah Dewilde, MA, MSc Richa Dhawan, MD Seetal Dodd, PhD Viviana Dominguez Trobo, MD, MSc Sahar El Aidy Samer El-Kamary, MD, MS, MPH Lorie Ellis, PhD Ramez Eskander, MD Ahmet Emre Eskazan, MD Gohar Eslami, PharmD, CDE Michel Farnier Gergely Feher, MD, PhD Diana Felton, MD Liang Feng, PhD Guido Filler, MD, PhD Douglas Fish, PharmD Farzaneh Foroughinia Katharine French, MD Moshe Fridman, PhD Michael Frumovitz Alex Z. Fu, PhD Paul S. Garcia, MD, PhD Christy Garcia Marc Garnick, MD Melissa Garrido, PhD Danielle Gatti, PharmD Heather Gelhorn M. Eric Gershwin, MD Gian Marco Ghiggeri Giorgios Giannopoulos, MD, PhD Chris Gibbons
Volume 38 Number 12
Clinical Therapeutics Jon Giles Maria Giner-Soriano Paul Glue Jennifer Goldman Kim Gomert-Handoko, PharmD, PhD Christopher Neal Graham David J. Greenblatt, MD Andreas H. Groll Sandeep Kumar Gupta, MD Bill J. Gurley, PhD Rachel Halpern, PhD Issam Hamadeh Guy Henri Hans, MD, PhD Kimberly Hanson, MD, MHS Emma Hawe Alison Haywood Andrew Hendifer, MD, MPH Robert Hendrickson, MD Adam Hersh, MD, PhD Elliot V. Hersh, DMD, MS, PhD Jason C. Hsu, PhD Catherine J. Hunter, MD Charles Huskins Silvio Inzucchi Benjamin Izar, MD, PhD Joseph D. Jackson, PhD Mihajlo B. Jakovljevic, MD, PhD Marjorie Jenkins, MD Xiling Jiang, PhD Xiling Jiang, PhD Cameron L. Jordan, PharmD Sunanda V. Kane Jia Kang, PhD Yea-Huei Kao Yang Jason H. Karnes, PharmD, PhD Sudeep Karve, PhD Bonnie Katalenich, MPH David M. Kern, MS Leslie Kerr Terence A. Ketter, MD Cheol Kim Kenneth Klinker, PharmD Linda Klumpers Brian Koo David W. Kubiak, PharmD Samantha Kiyomi Kurosky, MSPH Jennifer LaFemina, MD Sara Landes Lucia Larson, MD Matthew M. Laughon, MD Xiuning Le, MD, PhD Vivan W.Y. Lee, PharmD Janet Lewis, MD Guo-Fu Li Nanxin Li, PhD Wai Hon Lim, MD, PhD Alice Lim, PharmD Jeffrey Lipman, MD, MBBCh Randie R. Little, PhD
December 2016
Xinyue Liu, PhD Huang LiYing Marcello Locatelli, PhD Alan Lyles, ScD, MPH, RPh Carol Mancuso, MD Jay Margolis, PharmD Ana Paula Martins, PhD Lisa Masucci, MSc Faith Matham Cristiano Matos, MSc Josephine Mauskopf, PhD Marta Mazzetti Brendan McQuillen, MBBS, PhD Daniel McQuillen Alexander Mensch Colleen Jane Metge, PhD Juliana Meyers, MA James W. Mier, MD Eugene Millar Christopher-Paul Milne, DVM, MPH, JD Michael A. Moore, MD Anna Morin, PharmD Sarah S. Mougalian, MD Axel C. Mühlbacher, PhD Rudolph M. Navari Karl Emil Nelveg-Kristensen, MD Jason G. Newland, MD Bao-Anh Nguyen-Khoa Lucien Noens, MD, PhD Zaven Norigian Patrick J. O’Connor, MD, MPH J. Nicholas O’Donnell, PharmD Stefano Omboni, MD Mine Orlu Gul Katherine Ornstein, PhD Egon Anderson Ozer, MD, PhD Emma Palmer, PharmD Jeong Bae Park Keyur Patel Kennerly S. Patrick, PhD Robert B. Penfold Jose Perez-Urizar, PhD Hemant Phatak Kevin Pile Antonio Portolés, MD, PhD Emmanuel Pothos Jigar Rajpura, BPharm, MS Alan M. Rathbun, PhD, MPH Joseph Rella, MD Linda Amundstuen Reppe, MPharm Carmen Rodriguez Cerdeira Leonardo Roever, MHS Margaret Rothman, PhD J. Mark Ruscin, PharmD, BCPS Naomi Sacks, PhD Erin Saks Saad Salman, PharmD, Mphil Michael J. Satlin, MD, MS Robyn Sayner
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Acknowledgment Andre J. Scheen, MD, PhD Stephan Schmidt, PhD Jennifer Schroeck BS Pharm, PharmD Raghunadha Reddy Seelam, PhD Tara Seery, MD Ali Seifi, MD Rashmikant Shah, MD Mohamed Shahin, BPharm, MS, PhD Devada Singh-Franco, RPh, PharmD Stewart Siskin, PharmD Michael Smith Lee Smolen, BSEE Il-Suk Sohn, MD, PhD Yan Song, PhD Tacara Soones, MD, MPH Rosina Stamati, RPh Irving Steinberg, PharmD Dina Stolman, MD, MSPH Christophe P. Stove, PharmD, PhD Arthur B. Straughn, PharmD Donald E. Stull, Jr, PhD Hae Sun Suh, PhD, MPharm Hiromichi Suzuki, MD, PhD Marina Suzuki, PharmD Tara Symonds Shelagh Szabo, MSc Derek Tang, PhD, BSPharm Pranoot Tanpaiboon Jorg Taubel, MD Krishnansu Sujata Tewari, MD Angus Thompson Vennela Thumula, PhD Keith Tolley Mirjam Trame, PharmD, PhD Laurel Clayton Trantham Gianluca Trifirò Kavita Trivedi
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Saad Zafar Usmani Varun Vaidya, PhD Louise Vaz, MD, MPH Antonio Vaz Carneiro, MD, PhD Paolo Ventura Eva M. Vivian, PharmD, MS Steven C. Vlad, MD, PhD Harissios Vliagoftis Matthias von Herrath, MD Kelly Wade Kai Wang, MD, PhD Meng-Ting Wang Caroline Ward, PhD Dustin Waters Gerald F. Watts, DSc, PhD, MD Albert Wertheimer Zachary Willis, MD, MPH Robert J. Wirth, PhD Eric Wong Christopher Woodrell Jing Wu Suayib Yalcin Shibing Yang, PhD Eddy S. Yang, MD, PhD Xiaoqin Yang Jennifer Young, MD Guo Yu, PhD Huifeng Yun Philip Zachariah Edith T. Zemanick, MD Wei Zhao Lei Zheng, MD, PhD Songmao Zheng, PhD Yijie Zheng, PhD, MD Jie Zhou, PhD Xiaohui Zhou, MD, PhD
Volume 38 Number 12
A NOTE OF THANKS Peer review is the lifeblood of scientific publishing. To maintain the highest standards for the content of manuscripts published in Clinical Therapeutics, we seek independent reviewers from the faculties of medical schools and schools of pharmacy worldwide. Not only are our reviewers asked to provide in-depth reviews, but they are asked to do so within a short period of time. Clinical Therapeutics wishes to thank the following individuals for sharing their time and expertise this year in our ongoing effort to strengthen the peer-review process:
Mahran S. Abdel-Rahman, PhD Ivan Adamec Mayank Ajmera Emmanuel O. Akala, RPh, PhD Muhammad Akhktar, PhD John C. Alexander, MD Badraddin M. Al-Hadiya, PhD Lamia AlHajri, PharmD Carlos Javier Almeciga-Diaz, BPharm, PhD Amy Aloysi Ragaa Hosny Mohamad Al-Tahtawy, PhD Russ B. Altman Guohua An Tracy Anderson-Haag, PharmD, BCPS Rob Arbuckle Wilbert S. Aronow, MD Rehab H. Ashour, PhD Vozikis Athanassios Adel Bachour Rajesh Balkrishnan, PhD Sid Barritt Joshua I. Barzilay, MD Biswanath Basu Marisa Battistella Tom Belhorn Roxanna M. Bendixen, PhD Bryan Bennett James Richard Berenson, MD Gaetano Bertino, MD Palash Bhattacharya, PhD John A. Bosso David W. Boulton, PhD Ghada Bourjeily Carla Boutin-Foster Eric Boyce, PharmD John Bradley Geri Brown, MD Stephen Brunton Marilyn N. Bulloch, PharmD Christopher A. Burgess Kirsten Butterfoss Franceso Cacciatore, MD, PhD Terence Campbell, MD Xiting Cao, PhD Domenico Capone Michael Carrithers, MD, PhD John A. Carter Anthony M. Casapao, PharmD Edoardo Casiglia Marco Centanni, MD Chao Chen
A6
Yu-Huei Cheng, PhD David Cherney Lindsey Childs-Kean, PharmD, MPH Edward John Ciaccio, PhD Alexander Thomas Cohen, MBBS, MSc, MD Stanley B. Cohen, MD Pierre Colin Ignacio Conde, MD Pio Conti Stephen Joel Coons, PhD Paolo A. Cortesi, PhD Andrew L. Coveler, MD Stephanie Crawford, PhD, MPH Andrea Cruz Natalie Cusano Joao Data-Franco Lisa E. Davis, PharmD Stacie Deiner Oscar Della Pasqua, PhD, MD Rishi J. Desai Sarah Dewilde, MA, MSc Richa Dhawan, MD Seetal Dodd, PhD Viviana Dominguez Trobo, MD, MSc Sahar El Aidy Samer El-Kamary, MD, MS, MPH Lorie Ellis, PhD Ramez Eskander, MD Ahmet Emre Eskazan, MD Gohar Eslami, PharmD, CDE Michel Farnier Gergely Feher, MD, PhD Diana Felton, MD Liang Feng, PhD Guido Filler, MD, PhD Douglas Fish, PharmD Farzaneh Foroughinia Katharine French, MD Moshe Fridman, PhD Michael Frumovitz Alex Z. Fu, PhD Paul S. Garcia, MD, PhD Christy Garcia Marc Garnick, MD Melissa Garrido, PhD Danielle Gatti, PharmD Heather Gelhorn M. Eric Gershwin, MD Gian Marco Ghiggeri Giorgios Giannopoulos, MD, PhD Chris Gibbons
Volume 38 Number 12
Clinical Therapeutics Jon Giles Maria Giner-Soriano Paul Glue Jennifer Goldman Kim Gomert-Handoko, PharmD, PhD Christopher Neal Graham David J. Greenblatt, MD Andreas H. Groll Sandeep Kumar Gupta, MD Bill J. Gurley, PhD Rachel Halpern, PhD Issam Hamadeh Guy Henri Hans, MD, PhD Kimberly Hanson, MD, MHS Emma Hawe Alison Haywood Andrew Hendifer, MD, MPH Robert Hendrickson, MD Adam Hersh, MD, PhD Elliot V. Hersh, DMD, MS, PhD Jason C. Hsu, PhD Catherine J. Hunter, MD Charles Huskins Silvio Inzucchi Benjamin Izar, MD, PhD Joseph D. Jackson, PhD Mihajlo B. Jakovljevic, MD, PhD Marjorie Jenkins, MD Xiling Jiang, PhD Xiling Jiang, PhD Cameron L. Jordan, PharmD Sunanda V. Kane Jia Kang, PhD Yea-Huei Kao Yang Jason H. Karnes, PharmD, PhD Sudeep Karve, PhD Bonnie Katalenich, MPH David M. Kern, MS Leslie Kerr Terence A. Ketter, MD Cheol Kim Kenneth Klinker, PharmD Linda Klumpers Brian Koo David W. Kubiak, PharmD Samantha Kiyomi Kurosky, MSPH Jennifer LaFemina, MD Sara Landes Lucia Larson, MD Matthew M. Laughon, MD Xiuning Le, MD, PhD Vivan W.Y. Lee, PharmD Janet Lewis, MD Guo-Fu Li Nanxin Li, PhD Wai Hon Lim, MD, PhD Alice Lim, PharmD Jeffrey Lipman, MD, MBBCh Randie R. Little, PhD
December 2016
Xinyue Liu, PhD Huang LiYing Marcello Locatelli, PhD Alan Lyles, ScD, MPH, RPh Carol Mancuso, MD Jay Margolis, PharmD Ana Paula Martins, PhD Lisa Masucci, MSc Faith Matham Cristiano Matos, MSc Josephine Mauskopf, PhD Marta Mazzetti Brendan McQuillen, MBBS, PhD Daniel McQuillen Alexander Mensch Colleen Jane Metge, PhD Juliana Meyers, MA James W. Mier, MD Eugene Millar Christopher-Paul Milne, DVM, MPH, JD Michael A. Moore, MD Anna Morin, PharmD Sarah S. Mougalian, MD Axel C. Mühlbacher, PhD Rudolph M. Navari Karl Emil Nelveg-Kristensen, MD Jason G. Newland, MD Bao-Anh Nguyen-Khoa Lucien Noens, MD, PhD Zaven Norigian Patrick J. O’Connor, MD, MPH J. Nicholas O’Donnell, PharmD Stefano Omboni, MD Mine Orlu Gul Katherine Ornstein, PhD Egon Anderson Ozer, MD, PhD Emma Palmer, PharmD Jeong Bae Park Keyur Patel Kennerly S. Patrick, PhD Robert B. Penfold Jose Perez-Urizar, PhD Hemant Phatak Kevin Pile Antonio Portolés, MD, PhD Emmanuel Pothos Jigar Rajpura, BPharm, MS Alan M. Rathbun, PhD, MPH Joseph Rella, MD Linda Amundstuen Reppe, MPharm Carmen Rodriguez Cerdeira Leonardo Roever, MHS Margaret Rothman, PhD J. Mark Ruscin, PharmD, BCPS Naomi Sacks, PhD Erin Saks Saad Salman, PharmD, Mphil Michael J. Satlin, MD, MS Robyn Sayner
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Acknowledgment Andre J. Scheen, MD, PhD Stephan Schmidt, PhD Jennifer Schroeck BS Pharm, PharmD Raghunadha Reddy Seelam, PhD Tara Seery, MD Ali Seifi, MD Rashmikant Shah, MD Mohamed Shahin, BPharm, MS, PhD Devada Singh-Franco, RPh, PharmD Stewart Siskin, PharmD Michael Smith Lee Smolen, BSEE Il-Suk Sohn, MD, PhD Yan Song, PhD Tacara Soones, MD, MPH Rosina Stamati, RPh Irving Steinberg, PharmD Dina Stolman, MD, MSPH Christophe P. Stove, PharmD, PhD Arthur B. Straughn, PharmD Donald E. Stull, Jr, PhD Hae Sun Suh, PhD, MPharm Hiromichi Suzuki, MD, PhD Marina Suzuki, PharmD Tara Symonds Shelagh Szabo, MSc Derek Tang, PhD, BSPharm Pranoot Tanpaiboon Jorg Taubel, MD Krishnansu Sujata Tewari, MD Angus Thompson Vennela Thumula, PhD Keith Tolley Mirjam Trame, PharmD, PhD Laurel Clayton Trantham Gianluca Trifirò Kavita Trivedi
A8
Saad Zafar Usmani Varun Vaidya, PhD Louise Vaz, MD, MPH Antonio Vaz Carneiro, MD, PhD Paolo Ventura Eva M. Vivian, PharmD, MS Steven C. Vlad, MD, PhD Harissios Vliagoftis Matthias von Herrath, MD Kelly Wade Kai Wang, MD, PhD Meng-Ting Wang Caroline Ward, PhD Dustin Waters Gerald F. Watts, DSc, PhD, MD Albert Wertheimer Zachary Willis, MD, MPH Robert J. Wirth, PhD Eric Wong Christopher Woodrell Jing Wu Suayib Yalcin Shibing Yang, PhD Eddy S. Yang, MD, PhD Xiaoqin Yang Jennifer Young, MD Guo Yu, PhD Huifeng Yun Philip Zachariah Edith T. Zemanick, MD Wei Zhao Lei Zheng, MD, PhD Songmao Zheng, PhD Yijie Zheng, PhD, MD Jie Zhou, PhD Xiaohui Zhou, MD, PhD
Volume 38 Number 12