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A2 POLYMORPHISM OF GLYCOPROTEIN IIIA AS AN AGE-DEPENDENT RISK FACTOR FOR MYOCARDIAL INFARCTION: A META-ANALYSIS
A261 JACC April 1, 2014 Volume 63, Issue 12
Acute Coronary Syndromes The PlA1/A2 Polymorphism of Glycoprotein IIIa as an Age-Dependent Risk Factor for Myocardial Infarction: A Meta-Analysis Poster Contributions Hall C Monday, March 31, 2014, 9:45 a.m.-10:30 a.m.
Session Title: Acute Coronary Syndromes: Biologic Considerations Abstract Category: 1. Acute Coronary Syndromes: Clinical Presentation Number: 1265-255 Authors: Christopher Nicholas Floyd, Agnesa Mustafa, Albert Ferro, King’s College London, London, United Kingdom Background: The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been associated with myocardial infarction (MI), especially in younger subjects. The true nature of this association is unclear due to poor agreement between studies. We have therefore performed this meta-analysis to examine the strength of association between carriage of the PlA2 allele and MI. Methods: Electronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated. The primary outcome measure was MI, with sub-group analyses performed based on subject age at time of event. Results: 57 studies were eligible for statistical analysis and included 16,863 cases and 23,829 controls. Carriage of the PlA2 allele was significantly associated with MI (n=40,692; OR 1.077, 95% CI 1.024-1.132; p=0.004) but with significant publication bias (p=0.040). The degree of association with MI increased with decreasing age of subjects (Figure 1). Sub-group analyses had a low probability of publication bias (all p<0.05). Conclusions: It is unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.
Acute Coronary Syndromes The PlA1/A2 Polymorphism of Glycoprotein IIIa as an Age-Dependent Risk Factor for Myocardial Infarction: A Meta-Analysis Poster Contributions Hall C Monday, March 31, 2014, 9:45 a.m.-10:30 a.m.
Session Title: Acute Coronary Syndromes: Biologic Considerations Abstract Category: 1. Acute Coronary Syndromes: Clinical Presentation Number: 1265-255 Authors: Christopher Nicholas Floyd, Agnesa Mustafa, Albert Ferro, King’s College London, London, United Kingdom Background: The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been associated with myocardial infarction (MI), especially in younger subjects. The true nature of this association is unclear due to poor agreement between studies. We have therefore performed this meta-analysis to examine the strength of association between carriage of the PlA2 allele and MI. Methods: Electronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated. The primary outcome measure was MI, with sub-group analyses performed based on subject age at time of event. Results: 57 studies were eligible for statistical analysis and included 16,863 cases and 23,829 controls. Carriage of the PlA2 allele was significantly associated with MI (n=40,692; OR 1.077, 95% CI 1.024-1.132; p=0.004) but with significant publication bias (p=0.040). The degree of association with MI increased with decreasing age of subjects (Figure 1). Sub-group analyses had a low probability of publication bias (all p<0.05). Conclusions: It is unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.