Addition of trifluorodiazoethane to unactivated aldehydes

ADDITION

OF TRIFLUORODIAZOETHANE

TO UNACTIVATED

ALDEHYDES

Marc Tordeux and Claude Wakselman C.N.R.S.-C.E.R.C.O.A.

2, rue Henry Dunant 94320 Thiais FRANCE

The poorly reactive add to unactivated performed

aldehydes

in presence

mainly to homologated a trifluoromethyl

2,2,2 trifluorodiazoethane

is able to

provided that the reaction

of Lewis acids. This condensation

is leads

ketones and aldehydes a substituted

by

group. 1) Lewis acid

CF3CHN2 + RCHO

.-> 2) H30+

0 R-:-CH2-CF3

t R-CH-CHO