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Aggressive Adenomatoid Odontogenic Tumor Misdiagnosed as Dentigerous Cyst Showing Adjacent Tooth Mobility and Root Resorption
OOOO Volume 119, Number 3 ab39266) and MdM2 (Monoclonal Anti-MDM2 antibody [2A10] ab16895). Results: Moderate and strong expressions for PTCH in ameloblast and stellate reticulum were 78.6% and 60.7% respectively. Only 3 (10.7%) cases expressed MdM2. Conclusions: The importance of our study is that it supports, in theory, anti-PTCH/SHH chemotherapeutics for Nigerian ameloblastoma cases and also infers the possible additional use of anti-p53 agents. Keywords: PTCH-1, MdM2, Ameloblastoma, Chemotherapeutics
AGGRESSIVE ADENOMATOID ODONTOGENIC TUMOR MISDIAGNOSED AS DENTIGEROUS CYST SHOWING ADJACENT TOOTH MOBILITY AND ROOT RESORPTION Suna Erkilic1, Bilal Ege2, Mutan Hamdi Aras2, 1Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic tumor which is painless, noninvasive and grows slowly. It generally appears to be unilocular radiolucency surrounding the crown of unerupted teeth in the maxillary anterior region at the age of second decade in females. However, we introduce a rare case of AOT growing with significant aggressive behavior such as displacement and root resorption of teeth, expansion and partial perforation of bone around the unerupted mandibular canine. A 13-year-old girl was referred to our clinic with painless swelling and tooth mobility in the left mandibular anterior region. Histopathological examination diagnosed as AOT composed solid nodule of cuboidal epithelial cells with small amount of eosinophilic material after biopsy. Followed by, total excision of the lesion was excised and the healing of postoperative 6th month was uneventfully. Keywords: Adenomatoid Odontogenic Tumour, odontogenic tumor, mandibula
METASTATIC RENAL COLLECTING DUCT CARCINOMA OF THE ORAL CAVITY AFTER TOOTH EXTRACTION: A RARE CASE REPORT Suna Erkilic1, Aydin Keskinruzgar2, Zehra Bozdag1, Omer Gunhan3, 1 Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep,Turkey; 2Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep; 3Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey Metastatic cancers of the oral cavity are uncommon. They may occur in the oral soft tissues or in the jawbones. The primary sites of the oral metastatic tumors are lung, kidney, liver, and prostate, breast, female genital organs and colo-rectum. A 54years old man presented with erythema and swelling of the left mandible after tooth extraction. The lesion was similar to pyogenic granuloma by inspection. A biopsy taken from the gingival tissue and extraction socket showed adenocarcinoma, indicating metastasis of undiscovered primary cancer. As hematuria was learned from his medical history, patient’s urinary system was investigated and renal mass was detected. Biopsy from the mass showed the same histopathologic features with gingiva diagnosed as collecting duct carcinoma. The patient has been treated with chemotherapy. According to our knowledge our case is the first
ABSRACTS Abstracts e125 one in the literature as metastatic renal collecting duct carcinoma of the oral cavity after tooth extraction. Keywords: Collecting duct carcinoma, renal cell carcinoma, metastasis, oral cavity, tooth extraction
PLEXIFORM NEUROFIBROMA OF THE TONGUE Suna Erkilic1, Zehra Bozdag1, Fatih Celenk2, 1Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Otorhinolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Although benign peripheral nerve sheath tumors of head and neck are common, these tumors are rarely seen in oral cavity. 47% of patients affected by neurofibromatosis display oral manifestations. A three year old boy with a history of congenital tongue mass was presented to our hospital. His parents realised growing of the mass for last 5 months. Oral cavity examination showed a soft mass, was 2 cm in size. There was a history of congenital heart disease including pulmonary valve stenosis and atrial septal defect. There was cafe-au-lait spots without cutanous neurofibromas on physical examination. On pathologic examination, the lesion consisted of numerous nerve cells and ganglion cells mixed with spindle cells within a fibromyxoid stroma was positive with S100. The lesion reported as plexiform neurofibroma. We reported this case according to the rarity. Neurofibromas of the tongue should be kept in mind in the differential diagnosis of tongue masses. Keywords: Tongue, Plexiform Neurofibroma, Neurofibromatosis
GHOST CELL ODONTOGENIC CARCINOMA. A CASE REPORT AND REVIEW OF THE LITERATURE Margarita Alberola1, Sherley Diaz1, Berta Ferrer1, Myram Martos2, Juan Antonio Hueto2, Sahyly Siurana3, Socorro Bescos2, Santiago Ramón Y. Cajal1, 1Pathology Department Vall d’ Hebron University Hospital, Barcelona, Spain; 2Oral and Maxillofacial Surgery Department Vall d’ Hebron University Hospital, Barcelona, Spain; 3MR Unit (IDI) Radiology Department Vall d’ Hebron University Hospital, Barcelona, Spain Introduction: Ghost cell odontogenic carcinoma (GCOC) is a rare, malignant tumor, less than 30 cases reported. The main differential diagnosis is ameloblastic carcinoma. The biological behavior is variable, indolent or aggressive, however distant metastases are uncommon. Case Report: A 70-year-old female presented with maxillary pain. MRI revealed an extensive mass on the right side of the palate with invasion of pterygoid apophysis and second portion of trigeminal nerve. The patient underwent right maxillectomy. Adjuvant radiotherapy was given. Results: Tumor measured 3.93.5cm. Histology showed proliferation of odontogenic type, ameloblastic-like, arranged in islands and trabeculae with atypia and mitosis. Anucleated eosinophilic aggregates (ghost cells) were trapped in the epithelium. Surgical margins were focally affected. Conclusion: In the differential diagnosis with ameloblastic carcinoma, the ghost cells are the clue. The recommended treatment is wide surgical excision; utility of adjuvant radio/chemotherapy is controversial. The patient is alive, disease free, after 6 months. Keywords: Ghost Cell, Odontogenic Carcinoma, Odontogenic Tumor
AGGRESSIVE ADENOMATOID ODONTOGENIC TUMOR MISDIAGNOSED AS DENTIGEROUS CYST SHOWING ADJACENT TOOTH MOBILITY AND ROOT RESORPTION Suna Erkilic1, Bilal Ege2, Mutan Hamdi Aras2, 1Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic tumor which is painless, noninvasive and grows slowly. It generally appears to be unilocular radiolucency surrounding the crown of unerupted teeth in the maxillary anterior region at the age of second decade in females. However, we introduce a rare case of AOT growing with significant aggressive behavior such as displacement and root resorption of teeth, expansion and partial perforation of bone around the unerupted mandibular canine. A 13-year-old girl was referred to our clinic with painless swelling and tooth mobility in the left mandibular anterior region. Histopathological examination diagnosed as AOT composed solid nodule of cuboidal epithelial cells with small amount of eosinophilic material after biopsy. Followed by, total excision of the lesion was excised and the healing of postoperative 6th month was uneventfully. Keywords: Adenomatoid Odontogenic Tumour, odontogenic tumor, mandibula
METASTATIC RENAL COLLECTING DUCT CARCINOMA OF THE ORAL CAVITY AFTER TOOTH EXTRACTION: A RARE CASE REPORT Suna Erkilic1, Aydin Keskinruzgar2, Zehra Bozdag1, Omer Gunhan3, 1 Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep,Turkey; 2Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep; 3Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey Metastatic cancers of the oral cavity are uncommon. They may occur in the oral soft tissues or in the jawbones. The primary sites of the oral metastatic tumors are lung, kidney, liver, and prostate, breast, female genital organs and colo-rectum. A 54years old man presented with erythema and swelling of the left mandible after tooth extraction. The lesion was similar to pyogenic granuloma by inspection. A biopsy taken from the gingival tissue and extraction socket showed adenocarcinoma, indicating metastasis of undiscovered primary cancer. As hematuria was learned from his medical history, patient’s urinary system was investigated and renal mass was detected. Biopsy from the mass showed the same histopathologic features with gingiva diagnosed as collecting duct carcinoma. The patient has been treated with chemotherapy. According to our knowledge our case is the first
ABSRACTS Abstracts e125 one in the literature as metastatic renal collecting duct carcinoma of the oral cavity after tooth extraction. Keywords: Collecting duct carcinoma, renal cell carcinoma, metastasis, oral cavity, tooth extraction
PLEXIFORM NEUROFIBROMA OF THE TONGUE Suna Erkilic1, Zehra Bozdag1, Fatih Celenk2, 1Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Otorhinolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Although benign peripheral nerve sheath tumors of head and neck are common, these tumors are rarely seen in oral cavity. 47% of patients affected by neurofibromatosis display oral manifestations. A three year old boy with a history of congenital tongue mass was presented to our hospital. His parents realised growing of the mass for last 5 months. Oral cavity examination showed a soft mass, was 2 cm in size. There was a history of congenital heart disease including pulmonary valve stenosis and atrial septal defect. There was cafe-au-lait spots without cutanous neurofibromas on physical examination. On pathologic examination, the lesion consisted of numerous nerve cells and ganglion cells mixed with spindle cells within a fibromyxoid stroma was positive with S100. The lesion reported as plexiform neurofibroma. We reported this case according to the rarity. Neurofibromas of the tongue should be kept in mind in the differential diagnosis of tongue masses. Keywords: Tongue, Plexiform Neurofibroma, Neurofibromatosis
GHOST CELL ODONTOGENIC CARCINOMA. A CASE REPORT AND REVIEW OF THE LITERATURE Margarita Alberola1, Sherley Diaz1, Berta Ferrer1, Myram Martos2, Juan Antonio Hueto2, Sahyly Siurana3, Socorro Bescos2, Santiago Ramón Y. Cajal1, 1Pathology Department Vall d’ Hebron University Hospital, Barcelona, Spain; 2Oral and Maxillofacial Surgery Department Vall d’ Hebron University Hospital, Barcelona, Spain; 3MR Unit (IDI) Radiology Department Vall d’ Hebron University Hospital, Barcelona, Spain Introduction: Ghost cell odontogenic carcinoma (GCOC) is a rare, malignant tumor, less than 30 cases reported. The main differential diagnosis is ameloblastic carcinoma. The biological behavior is variable, indolent or aggressive, however distant metastases are uncommon. Case Report: A 70-year-old female presented with maxillary pain. MRI revealed an extensive mass on the right side of the palate with invasion of pterygoid apophysis and second portion of trigeminal nerve. The patient underwent right maxillectomy. Adjuvant radiotherapy was given. Results: Tumor measured 3.93.5cm. Histology showed proliferation of odontogenic type, ameloblastic-like, arranged in islands and trabeculae with atypia and mitosis. Anucleated eosinophilic aggregates (ghost cells) were trapped in the epithelium. Surgical margins were focally affected. Conclusion: In the differential diagnosis with ameloblastic carcinoma, the ghost cells are the clue. The recommended treatment is wide surgical excision; utility of adjuvant radio/chemotherapy is controversial. The patient is alive, disease free, after 6 months. Keywords: Ghost Cell, Odontogenic Carcinoma, Odontogenic Tumor