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Applications of dynamic NMR spectroscopy to Organic chemistry (Methods in stereochemical analysis, Vol. 4)
JOURNAL OF MAGNETIC RESONANCE
75,550-552 (1987)
Book Reviews Applications of Dynamic NMR Spectroscopy to Organic Chemistry (Methods in Stereochemical Analysis, Vol. 4), Michinori Oki. VCH Publishers, Deerlield Beach, Florida. 1985. 423 pp. $92.50. The aim of this book is to communicate to organic chemists the power of the NMR method for investigating the dynamics (internal rotation, conformational exchanges, isomerization, etc.) of organic molecules and a view of the great variety of situations where the method is applicable. The principles of dynamic NMR spectroscopy are treated in a brief introductory chapter, and applications are illustrated in eight succeeding chapters dealing with restricted rotation about partial double bonds, such as those in amides, amide vinylogs, or fulvenes, about s$-s~ bonds, s8-sp3 bonds, sp3sp’bonds, conformational interconversion in cyclic compounds, dynamics of amines and imines, electrocyclic reactions, rapid internal rearrangements,and associationdissociation processes.A very broad and comprehensivecoverageof theseapplications is given, and the book will certainly be valuable to organic chemists interested in molecular dynamics as a guide and referenceto what has been done in each of these areas. The subject matter is admirably organized for this purpose. The book is not suitable as a how to do it manual, however. The treatment of the principles and methodology in Chapter 1 is too brief, qualitative, and uncritical. It contains a few statements of dubious validity. For example, the opening sentencesread: “Organic chemists may sometimes encounter a ‘H NMR spectrum that shows a broad band in addition to normal sharp signals. The cause for this phenomenon is an exchange process of nucleus sites that is taking place under the conditions obtaining.” This ignores the possibility that the broad signal may arise from coupling with quadrupolerelaxed 14N,or selectiveparamagneticbroadening, two common sourcesof line broadening in the spectra of organic molecules. Limitations on some of the formulas, such as equal population of sites, are omitted. Lineshape analysis using density matrix methods is mentioned, but not expounded. H, dependenceof T,, and repetition-rate dependenceof T2 determined by the CPMG method are not mentioned. The book is beautifully printed, contains no typographical errors I could find, and has a useful subject index. AKSELA.BOTHNER-BY
Department of Chemistry Carnegie-Mellon University Modern Techniquesin High-Resolution FT-NMR, Narayanan Chandrakumar and Sankaran Subramanian. Springer-Verlag, New York. 1987. 388 pp. $59.00. There are at least three levels at which one could pitch a book on modem NMR. One would be to the community who uses NMR but does not necessarily need or 0022-23&I/87$3.00 copyrisht @ 1987 by Acadaic Rcss, Inc. All rlgbts of tqmdttction in any form -ed.
550
75,550-552 (1987)
Book Reviews Applications of Dynamic NMR Spectroscopy to Organic Chemistry (Methods in Stereochemical Analysis, Vol. 4), Michinori Oki. VCH Publishers, Deerlield Beach, Florida. 1985. 423 pp. $92.50. The aim of this book is to communicate to organic chemists the power of the NMR method for investigating the dynamics (internal rotation, conformational exchanges, isomerization, etc.) of organic molecules and a view of the great variety of situations where the method is applicable. The principles of dynamic NMR spectroscopy are treated in a brief introductory chapter, and applications are illustrated in eight succeeding chapters dealing with restricted rotation about partial double bonds, such as those in amides, amide vinylogs, or fulvenes, about s$-s~ bonds, s8-sp3 bonds, sp3sp’bonds, conformational interconversion in cyclic compounds, dynamics of amines and imines, electrocyclic reactions, rapid internal rearrangements,and associationdissociation processes.A very broad and comprehensivecoverageof theseapplications is given, and the book will certainly be valuable to organic chemists interested in molecular dynamics as a guide and referenceto what has been done in each of these areas. The subject matter is admirably organized for this purpose. The book is not suitable as a how to do it manual, however. The treatment of the principles and methodology in Chapter 1 is too brief, qualitative, and uncritical. It contains a few statements of dubious validity. For example, the opening sentencesread: “Organic chemists may sometimes encounter a ‘H NMR spectrum that shows a broad band in addition to normal sharp signals. The cause for this phenomenon is an exchange process of nucleus sites that is taking place under the conditions obtaining.” This ignores the possibility that the broad signal may arise from coupling with quadrupolerelaxed 14N,or selectiveparamagneticbroadening, two common sourcesof line broadening in the spectra of organic molecules. Limitations on some of the formulas, such as equal population of sites, are omitted. Lineshape analysis using density matrix methods is mentioned, but not expounded. H, dependenceof T,, and repetition-rate dependenceof T2 determined by the CPMG method are not mentioned. The book is beautifully printed, contains no typographical errors I could find, and has a useful subject index. AKSELA.BOTHNER-BY
Department of Chemistry Carnegie-Mellon University Modern Techniquesin High-Resolution FT-NMR, Narayanan Chandrakumar and Sankaran Subramanian. Springer-Verlag, New York. 1987. 388 pp. $59.00. There are at least three levels at which one could pitch a book on modem NMR. One would be to the community who uses NMR but does not necessarily need or 0022-23&I/87$3.00 copyrisht @ 1987 by Acadaic Rcss, Inc. All rlgbts of tqmdttction in any form -ed.
550