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Are you asking what time did your patients take sleeping pills?: Sleeping pill taking time and patient satisfaction
Abstracts/Sleep Medicine 16 (2015) S2–S199
Mode 2 to Rest C shows significant increase (from 335.5 to 576.4 ms2, p-value = 0.018). Such an increase could be attributed from the effect of Mode 2 as it turns out to have the highest LF/HF ratio (28.6 ms2, p < 0.05). Our interpretation is that among the four breathing patterns Mode 2 is the best approach to activate ANS regulation leading to the subjects’ relaxation. It is worth to note that HFnu is low for the periods of Rest B, C, D, and E (0.24, 0.32, 0.30 and 0.32%, respectively) compared with that of Rest A (0.43%). Furthermore, the LF/HF ratios (5.23, 4.14, 5.28 and 4.63) of those resting periods are all higher than that of the Rest-A period (1.69). The explanation of these results is likely due to the physical conditions of subjects, whose health is so good that the ANS effect was quickly balanced back right after each respiratory regulation period. Conclusion: We have demonstrated that PNS can be activated by respiratory regulation. Particularly, the breathing cycle noted as Mode 2 here for 3 minutes can make human body relax. Comprehensive studies of using Mode 2 to investigate the effect on patients who have sleeping disorders and stress issues are in progress. http://dx.doi.org/10.1016/j.sleep.2015.02.1511
Sleep disorders increase the risk of venous thromboembolism in individuals without sleep apnea: A nationwide populationbased cohort study W. Chung 1, Y. Chen 2, C. Lin 3, C. Kao 4 1 Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan 2 Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan 3 Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan 4 Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
Introduction: Studies investigating the relationship between sleep disorders (SDs) and the risk of venous thromboembolism (VTE) are scarce. This study evaluated whether the risk of VTE was associated with SDs other than sleep apnea in Taiwan. Materials and methods: This study included 46,371 patients with SDs and a total of 92,742 controls without SDs between 1998 and 2001 by using National Health Insurance Research Database in Taiwan. The date of first diagnosis of SD was defined as the index date. For each corresponding SD patient, four controls without SD as a comparison cohort were selected using a systematic randomsampling method, and frequency matched by age, sex, and index year. The follow-up period began from the date of entering the study cohort to the date of a VTE event, censoring, or December 31, 2011. We conducted Cox proportional hazard regression analysis to estimate the effects of SDs on VTE risk. Results: The SD cohort had a 1.79-fold adjusted hazard ratio (HR) of subsequent VTE, compared with the cohort without SD (95% confidence interval (CI) = 1.49–2.16). The incidence of VTE increased as age increased for both cohorts and was higher for the patients in the SD cohort. However, the adjusted HRs of VTE were significantly higher for SD patients aged ≦49 years (HR = 3.29, 95% CI = 2.12–5.12) and 50–64 years (HR = 2.43, 95% CI = 1.76–3.35), but nonsignificant for the oldest group (HR = 1.11, 95% CI = 0.84–1.47), compared with the controls. The multiplicative increased risk of VTE was significant for the SD patients with any comorbidity. Conclusion: The current study determined that patients with nonapnea SD were at a higher risk of developing VTE. Because
S153
patients with non-apnea SD are progressively increasing, to enhance sleep problem management may be important for decreasing VTE events. Acknowledgements: The study acknowledges Taiwan Ministry Health and Welfare Clinical Trial and Research Center for Excellence, and the Taiwan Ministry Health and Welfare Cancer Research Center for Excellence. http://dx.doi.org/10.1016/j.sleep.2015.02.1512
Are you asking what time did your patients take sleeping pills?: Sleeping pill taking time and patient satisfaction S. Chung, S. Youn, K. Yi, B. Park, S. Lee Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Korea
Introduction: Taking hypnotics 30 minutes before bedtime is the usual guidance, but some patients report dissatisfaction with their sleeping pills. We investigated whether the timing of when sleeping pills are taken influences patient satisfaction with these drugs. Materials and methods: Eighty-eight primary insomnia patients currently taking hypnotics were selected. The time to take their sleeping pills, bedtime, sleep onset time, and wake up time were obtained from their medical records. Subjects were also categorized into satisfied or dissatisfied groups. Results: The time at which hypnotics were taken (p < 0.001) and bedtime (p < 0.001), but not the sleep onset time or wake up time, occurred later in the night in the satisfied group. The duration from taking pills to sleep onset (31.8 ± 21.3 minutes) and to wake up time (7.1 ± 1.2 hours) were significantly shorter in the satisfied group (142.9 ± 72.2 minutes vs. 9.4 ± 1.3 hours). Patients in both groups took hypnotics within 30 minutes before bedtime, despite a significant difference in duration from pills to bedtime (p < 0.001). Logistic regression analysis revealed that patient satisfaction with hypnotics could be predicted by a short duration from taking pills to sleep onset (odds ration = 0.01; 95% confidence interval [0.001– 0.19]) and a short duration from taking pills to wake up time (0.36; [0.15–0.88], F = 33.80, p < 0.001). Conclusion: Taking sleeping pills at a later time and a shorter interval between taking pills and wake up time may increase a patient’s satisfaction with hypnotics. We propose that physicians advise patients to take sleeping pills roughly 7 hours before their usual wake up time rather than 30 minutes before bedtime. http://dx.doi.org/10.1016/j.sleep.2015.02.1513
The prevalence of depression and insomnia among patients; results from Health Insurance and Review and Assessment Service – National Patient Sample B. Park, K. Yi, J. Lee, S. Chung Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Korea
Introduction: The aim of this study is to explore the prevalence of depression and insomnia among patients with the top 10th most common cancers in South Korea. Materials and methods: We analyzed data from the 2011 Health Insurance and Review and Assessment Service – National Patient Sample (HIRA-NPS) of South Korea. It consisted of records for medical care and medications of 1,375,842 (3% of total records)
Mode 2 to Rest C shows significant increase (from 335.5 to 576.4 ms2, p-value = 0.018). Such an increase could be attributed from the effect of Mode 2 as it turns out to have the highest LF/HF ratio (28.6 ms2, p < 0.05). Our interpretation is that among the four breathing patterns Mode 2 is the best approach to activate ANS regulation leading to the subjects’ relaxation. It is worth to note that HFnu is low for the periods of Rest B, C, D, and E (0.24, 0.32, 0.30 and 0.32%, respectively) compared with that of Rest A (0.43%). Furthermore, the LF/HF ratios (5.23, 4.14, 5.28 and 4.63) of those resting periods are all higher than that of the Rest-A period (1.69). The explanation of these results is likely due to the physical conditions of subjects, whose health is so good that the ANS effect was quickly balanced back right after each respiratory regulation period. Conclusion: We have demonstrated that PNS can be activated by respiratory regulation. Particularly, the breathing cycle noted as Mode 2 here for 3 minutes can make human body relax. Comprehensive studies of using Mode 2 to investigate the effect on patients who have sleeping disorders and stress issues are in progress. http://dx.doi.org/10.1016/j.sleep.2015.02.1511
Sleep disorders increase the risk of venous thromboembolism in individuals without sleep apnea: A nationwide populationbased cohort study W. Chung 1, Y. Chen 2, C. Lin 3, C. Kao 4 1 Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan 2 Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan 3 Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan 4 Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
Introduction: Studies investigating the relationship between sleep disorders (SDs) and the risk of venous thromboembolism (VTE) are scarce. This study evaluated whether the risk of VTE was associated with SDs other than sleep apnea in Taiwan. Materials and methods: This study included 46,371 patients with SDs and a total of 92,742 controls without SDs between 1998 and 2001 by using National Health Insurance Research Database in Taiwan. The date of first diagnosis of SD was defined as the index date. For each corresponding SD patient, four controls without SD as a comparison cohort were selected using a systematic randomsampling method, and frequency matched by age, sex, and index year. The follow-up period began from the date of entering the study cohort to the date of a VTE event, censoring, or December 31, 2011. We conducted Cox proportional hazard regression analysis to estimate the effects of SDs on VTE risk. Results: The SD cohort had a 1.79-fold adjusted hazard ratio (HR) of subsequent VTE, compared with the cohort without SD (95% confidence interval (CI) = 1.49–2.16). The incidence of VTE increased as age increased for both cohorts and was higher for the patients in the SD cohort. However, the adjusted HRs of VTE were significantly higher for SD patients aged ≦49 years (HR = 3.29, 95% CI = 2.12–5.12) and 50–64 years (HR = 2.43, 95% CI = 1.76–3.35), but nonsignificant for the oldest group (HR = 1.11, 95% CI = 0.84–1.47), compared with the controls. The multiplicative increased risk of VTE was significant for the SD patients with any comorbidity. Conclusion: The current study determined that patients with nonapnea SD were at a higher risk of developing VTE. Because
S153
patients with non-apnea SD are progressively increasing, to enhance sleep problem management may be important for decreasing VTE events. Acknowledgements: The study acknowledges Taiwan Ministry Health and Welfare Clinical Trial and Research Center for Excellence, and the Taiwan Ministry Health and Welfare Cancer Research Center for Excellence. http://dx.doi.org/10.1016/j.sleep.2015.02.1512
Are you asking what time did your patients take sleeping pills?: Sleeping pill taking time and patient satisfaction S. Chung, S. Youn, K. Yi, B. Park, S. Lee Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Korea
Introduction: Taking hypnotics 30 minutes before bedtime is the usual guidance, but some patients report dissatisfaction with their sleeping pills. We investigated whether the timing of when sleeping pills are taken influences patient satisfaction with these drugs. Materials and methods: Eighty-eight primary insomnia patients currently taking hypnotics were selected. The time to take their sleeping pills, bedtime, sleep onset time, and wake up time were obtained from their medical records. Subjects were also categorized into satisfied or dissatisfied groups. Results: The time at which hypnotics were taken (p < 0.001) and bedtime (p < 0.001), but not the sleep onset time or wake up time, occurred later in the night in the satisfied group. The duration from taking pills to sleep onset (31.8 ± 21.3 minutes) and to wake up time (7.1 ± 1.2 hours) were significantly shorter in the satisfied group (142.9 ± 72.2 minutes vs. 9.4 ± 1.3 hours). Patients in both groups took hypnotics within 30 minutes before bedtime, despite a significant difference in duration from pills to bedtime (p < 0.001). Logistic regression analysis revealed that patient satisfaction with hypnotics could be predicted by a short duration from taking pills to sleep onset (odds ration = 0.01; 95% confidence interval [0.001– 0.19]) and a short duration from taking pills to wake up time (0.36; [0.15–0.88], F = 33.80, p < 0.001). Conclusion: Taking sleeping pills at a later time and a shorter interval between taking pills and wake up time may increase a patient’s satisfaction with hypnotics. We propose that physicians advise patients to take sleeping pills roughly 7 hours before their usual wake up time rather than 30 minutes before bedtime. http://dx.doi.org/10.1016/j.sleep.2015.02.1513
The prevalence of depression and insomnia among patients; results from Health Insurance and Review and Assessment Service – National Patient Sample B. Park, K. Yi, J. Lee, S. Chung Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Korea
Introduction: The aim of this study is to explore the prevalence of depression and insomnia among patients with the top 10th most common cancers in South Korea. Materials and methods: We analyzed data from the 2011 Health Insurance and Review and Assessment Service – National Patient Sample (HIRA-NPS) of South Korea. It consisted of records for medical care and medications of 1,375,842 (3% of total records)