Wednesday, April 28 - Friday, April 30, 2010 (E-Poster Abstract Zone) Chang Gyu Park, Hong Seog Seo, Dong Joo Oh. Korea University Guro Hospital, Seoul, Republic of Korea. Background: Endovascular treatment (EVT) is considered an effective treatment in patients (pts) with critical limb ischemia (CLI) with active nonhealing wounds. There are limited data regarding the association between trace elements and wounded lower extremities. Methods: This study consisted of 128 consecutive CLI pts from June 2004 to November 2008. Among these pts, 46 (36%) presented with CLI and nonhealing wounds. We investigated whether there are differences in basal levels of trace elements and vitamins between wounded and nonwounded pts. Results: The baseline characteristics were similar between the 2 groups, except that more pts with wounds suffered from ischemic symptoms according to Rutherford Chronic Limb Ischemia Classification (p ⬍0.001), diabetes (87.0% vs. 45.0%, p ⬍0.001), and chronic renal insufficiency (CRI; 34.8% vs. 4.9%, p ⬍0.001). Basal trace element and vitamin levels showed lower ferrum and vitamin E␣ levels (p ⬍0.05), and Cu levels were higher in the wounded pts (Table). Although there was no significant difference in angiographic successful rate between the 2 groups, pts with wounds showed worse Limb Status Grade bilaterally after procedural (p ⬍0.001) and higher rates of periprocedural complications such as dissection (48.7% vs 29.8%, p ⫽ 0.004). However, the major clinical outcomes were similar between the 2 groups up to 6 months (Table).
Background:Peripheral vascular disease (PVD) is a known risk factor of significant coronary artery disease (CAD). The aim of this study was to analyze the association of PVD and CAD when a patient (pt) presents with significant PVD. Methods:This study enrolled 128 pts with significant lower extremity arterial disease who underwent percutaneous transluminal angioplasty (PTA). Pts were divided into 2 groups according to the target lesions location (iliofemoral-popliteal lesion: n ⫽ 70, infrapopliteal lesion: n ⫽ 22; both lesions: n ⫽ 36 pts) and analyzed the association with CAD and associated parameters. CAD was defined as angiographic stenosis ⱖ50% and significant CAD ⱖ70% stenosis. Results: The baseline clinical characteristics showed that the incidence of wound and diabetes mellitus were similar between the 2 groups. Regional wall motion abnormality on the echocardiography occurred in 21.1% of cases, and mean ejection fraction (EF) was 44.9 ⫾ 13.2%. Significant CAD with ⬎70% stenotic lesion was seen in 15 pts (11.6%) and similar between the 2 groups (38.6% vs 36.4%, p ⫽ 0.85). Thirty-one pts (24.2%) with significant CAD underwent PCI, which was similar between the 2 groups (35.7% vs 27.3%, p ⫽ 0.61). Iliofemoral-popliteal disease and concomitant infrapopliteal disease was seen in 33.5% of pts, and the converse in 66.1%. The incidence of other combined vascular disease was similar between the 2 groups (Table).
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Conclusion: Besides presenting with more severe ischemic symptoms and procedural complications in CLI, pts with wounds showed deficiency in some trace elements including ferrum and vitamin E␣, as well as elevated Cu level, which may play a role in the development, progression, or wound healing in pts with CLI.
AS-248 Association of Significant Peripheral Vascular Disease and Coronary Artery Disease in an Asian Population. Seung-Woon Rha, Ji Young Park, Kanhaiya L. Poddar, Sureshkumar Ramasamy, Lin Wang, Byoung Geol Choi, Ji Bak Kim, Seung Yong Shin, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh. Korea University Guro Hospital, Seoul, Republic of Korea.
Conclusion: Approximately 10% of pts with significant iliofemoral-popliteal or infrapopliteal disease undergoing PTA may have significant CAD in an Asian population. Iliofemoral-popliteal artery disease and infrapopliteal artery disease also showed a significant association.
The American Journal of Cardiology姞 APRIL 28 –30 2010 ANGIOPLASTY SUMMIT ABSTRACTS/E-Poster105B
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