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Assessment of Framingham risk score and systemic coronary risk evaluation in rosacea patients
Abstracts / Atherosclerosis 263 (2017) e111ee282 2 Department of Community Medicine, Kurume University School of Medicine, Kurume, Japan
Aim: We investigated the relationship between augmentation index (AI) and smoking habits in community-dwelling Japanese. Methods: This cross-sectional study enrolled 1,926 subjects (769 males and 1,157 females) aged 40 to 95 years who underwent a health check-up in a Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town in Kyushu Island in 2009. The subjects’ medical history, alcohol intake, smoking habit and current medications for hypertension, dyslipidemia and diabetes were ascertained by questionnaire. Radial arterial pressure wave analysis was used to obtain AI. We analyzed the data stratified by gender. Results: Age-adjusted means of AI in males showed a clear dose-response relationship in four categories of smoking habits (p¼0.010). There was no significant relationship between AI and smoking habits in females (p¼0.127). The significant dose-response relationship (p¼0.036) in males between AI and four categories of smoking habits still remained even after adjustment for age, body mass index, systolic blood pressure, estimated glomerular filtration rate, glucose, hypertensive medication and alcohol intake. Conclusions: The present study demonstrated that AI values were significantly associated with smoking habits in a dose-dependent manner in Japanese males.
PO266. ASSESSMENT OF FRAMINGHAM RISK SCORE AND SYSTEMIC CORONARY RISK EVALUATION IN ROSACEA PATIENTS Asli Akin Belli1, Ibrahim Altun2. 1 Mugla Sitki Kocman Education and Training Hospital, Department of Dermatology, Mugla, Turkey; 2 Mugla Sitki Kocman University, Faculty of Medicine, Department of Cardiology, Mugla, Turkey Aim: Even though some studies with contrary results have been reported, rosacea has been associated with cardiovascular diseases recently. We aimed to determine the frequency of cardiovascular risk by means of the Framingham risk score (FRS) and systemic coronary risk evaluation (SCORE) in rosacea patients compared with controls.
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Results: Eighty five rosacea patients and 90 controls (67 female, 23 male; mean 50.79 years) were included in the study. Of 85 rosacea patients, 44 (51.8%) had erythematotelengiectatic type and 41 (48.2%) had papulopustular type. The mean SCORE and FRS levels were not significantly different between rosacea and control groups (P < 0.05). The SCORE levels were correlated with the rosacea duration (P ¼ 0.034). The patients with papulopustular type rosacea had significantly higher cardiovascular risk than the patients with erythematotelengiectatic type (P > 0.05). Conclusions: Rosacea patients did not have an increased cardiovascular risk estimated by two validated models. However, the correlation between the SCORE levels and rosacea duration supports the role of inflammation in the rosacea pathogenesis. Further studies are needed including the patients with the four subtypes of rosacea to evaluate cardiovascular risk factors separately for each other.
PO267. GENDER DIFFERENCES IN ACUTE CORONARY SYNDROMES: DO THEY COUNT? Sofia Abbolito, Cristiano Miotti, Erica Mencarelli, Simone Burocchi, Vivanne Presta, Giovanna Gallo, Gerardo Salerno, Francesca Simonelli, Massimo Volpe, Luciano De Biase. Chair of Cardiology, Dept. Clinical and Molecular Medicine, Sapienza University of Rome, Italy Aim: INTRODUCTION: We investigated the different control of cardiovascular risk factors such as total cholesterol, LDL, HDL, apolipoprotein A, apolipoprotein B, apolipoprotein B/A1 ratio and Lp (a) at the onset of atherosclerotic disease in male and females. Methods: We consecutively enrolled 539 patients admitted to our Coronary Care Unit (CCU) with diagnosis of Acute Coronary Syndrome (ACS) (STEMI, NSTEMI, Unstable Angina) confirmed by a coronary angiography showing obstructive lesions (> 75%). We then divided this population into two groups: 1 (men) and 2 (women). Results: In the sample analyzed, 77% of patients are men and 23% women. Women are older than men at the onset of ischemic heart disease or during relapse. Probably because older, women are more often hypertensive (83% vs 63%), diabetics and with an impaired renal function. There were no significant differences in the values of total cholesterol, LDL and apolipoprotein B. In women, triglyceride values are lower than men (133 mg / dl vs. 151 mg / dl), while those of HDL are generally higher (46 mg / dl vs. 39 mg / dl). In women, the levels of apoA1 are higher (125 mg / dl vs. 111 mg / dl) and consequently the ratio apolipoprotein B / apolipoprotein A1 (0.81 vs 0.97) appears to be lower. The plasma levels of Lp (a) were elevated in 37% of the total population and especially in women, in which the average concentration is about 40 mg / dl: the difference between the genders was not statistically significant. Conclusion: From our data it appears that the distribution of risk factors for ACS is dependent on sex and that, in light of the different post ACS prognosis, in certain subpopulations of patients, can be taken in consideration different treatment strategies. Poster session: novel risk markers PO268. EFFECTS OF HEART RATE CONTROL WITH IVABRADINE AND B-BLOCKER VERSUS B-BLOCKER UPTITRATION ON ARTERIAL STIFFNESS IN CAD PATIENTS WITH MID-RANGE EF I. Katsytadze, Kateryna Amosova, Andrey Bezrodniy, Igor Gorda, Nataliya Shishkina, Olha Vasylenko. Bogomolets National Medical University, Kyiv, Ukraine
Ă
Methods: We conducted a case-control study between January 2015 and November 2016. Demographic information, rosacea duration and subtype, smoking history, lipid parameters, blood pressure levels, use of antihypertensive drug, fasting blood glucose (FBG), BMI, family history of coronary artery disease, presence of metabolic syndrome (MS), and presence of insulin resistance (IR), and points of the FRS and SCORE were systematically recorded.
Aim: To compare the effect of Ivabradine (Iv) plus bisoprolol (Bs) and Bs uptitration on arterial elastance (Ea), pulse wave velocity (PWV), augmentation index (AI) and NTproBNP in CAD patients with mid-range EF. Methods: In single-blind, parallel-group study 85 pts < 60 years (55±2,5) in sinus rhythm >70 bpm with CAD (stable angina CCS class I-II), documented MI>3 months, EF 35-45%, treated with Bs 5 mg od, were randomized into 2 groups. In Group 1 (n¼40) Iv was added (5mg bid
Aim: We investigated the relationship between augmentation index (AI) and smoking habits in community-dwelling Japanese. Methods: This cross-sectional study enrolled 1,926 subjects (769 males and 1,157 females) aged 40 to 95 years who underwent a health check-up in a Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town in Kyushu Island in 2009. The subjects’ medical history, alcohol intake, smoking habit and current medications for hypertension, dyslipidemia and diabetes were ascertained by questionnaire. Radial arterial pressure wave analysis was used to obtain AI. We analyzed the data stratified by gender. Results: Age-adjusted means of AI in males showed a clear dose-response relationship in four categories of smoking habits (p¼0.010). There was no significant relationship between AI and smoking habits in females (p¼0.127). The significant dose-response relationship (p¼0.036) in males between AI and four categories of smoking habits still remained even after adjustment for age, body mass index, systolic blood pressure, estimated glomerular filtration rate, glucose, hypertensive medication and alcohol intake. Conclusions: The present study demonstrated that AI values were significantly associated with smoking habits in a dose-dependent manner in Japanese males.
PO266. ASSESSMENT OF FRAMINGHAM RISK SCORE AND SYSTEMIC CORONARY RISK EVALUATION IN ROSACEA PATIENTS Asli Akin Belli1, Ibrahim Altun2. 1 Mugla Sitki Kocman Education and Training Hospital, Department of Dermatology, Mugla, Turkey; 2 Mugla Sitki Kocman University, Faculty of Medicine, Department of Cardiology, Mugla, Turkey Aim: Even though some studies with contrary results have been reported, rosacea has been associated with cardiovascular diseases recently. We aimed to determine the frequency of cardiovascular risk by means of the Framingham risk score (FRS) and systemic coronary risk evaluation (SCORE) in rosacea patients compared with controls.
e193
Results: Eighty five rosacea patients and 90 controls (67 female, 23 male; mean 50.79 years) were included in the study. Of 85 rosacea patients, 44 (51.8%) had erythematotelengiectatic type and 41 (48.2%) had papulopustular type. The mean SCORE and FRS levels were not significantly different between rosacea and control groups (P < 0.05). The SCORE levels were correlated with the rosacea duration (P ¼ 0.034). The patients with papulopustular type rosacea had significantly higher cardiovascular risk than the patients with erythematotelengiectatic type (P > 0.05). Conclusions: Rosacea patients did not have an increased cardiovascular risk estimated by two validated models. However, the correlation between the SCORE levels and rosacea duration supports the role of inflammation in the rosacea pathogenesis. Further studies are needed including the patients with the four subtypes of rosacea to evaluate cardiovascular risk factors separately for each other.
PO267. GENDER DIFFERENCES IN ACUTE CORONARY SYNDROMES: DO THEY COUNT? Sofia Abbolito, Cristiano Miotti, Erica Mencarelli, Simone Burocchi, Vivanne Presta, Giovanna Gallo, Gerardo Salerno, Francesca Simonelli, Massimo Volpe, Luciano De Biase. Chair of Cardiology, Dept. Clinical and Molecular Medicine, Sapienza University of Rome, Italy Aim: INTRODUCTION: We investigated the different control of cardiovascular risk factors such as total cholesterol, LDL, HDL, apolipoprotein A, apolipoprotein B, apolipoprotein B/A1 ratio and Lp (a) at the onset of atherosclerotic disease in male and females. Methods: We consecutively enrolled 539 patients admitted to our Coronary Care Unit (CCU) with diagnosis of Acute Coronary Syndrome (ACS) (STEMI, NSTEMI, Unstable Angina) confirmed by a coronary angiography showing obstructive lesions (> 75%). We then divided this population into two groups: 1 (men) and 2 (women). Results: In the sample analyzed, 77% of patients are men and 23% women. Women are older than men at the onset of ischemic heart disease or during relapse. Probably because older, women are more often hypertensive (83% vs 63%), diabetics and with an impaired renal function. There were no significant differences in the values of total cholesterol, LDL and apolipoprotein B. In women, triglyceride values are lower than men (133 mg / dl vs. 151 mg / dl), while those of HDL are generally higher (46 mg / dl vs. 39 mg / dl). In women, the levels of apoA1 are higher (125 mg / dl vs. 111 mg / dl) and consequently the ratio apolipoprotein B / apolipoprotein A1 (0.81 vs 0.97) appears to be lower. The plasma levels of Lp (a) were elevated in 37% of the total population and especially in women, in which the average concentration is about 40 mg / dl: the difference between the genders was not statistically significant. Conclusion: From our data it appears that the distribution of risk factors for ACS is dependent on sex and that, in light of the different post ACS prognosis, in certain subpopulations of patients, can be taken in consideration different treatment strategies. Poster session: novel risk markers PO268. EFFECTS OF HEART RATE CONTROL WITH IVABRADINE AND B-BLOCKER VERSUS B-BLOCKER UPTITRATION ON ARTERIAL STIFFNESS IN CAD PATIENTS WITH MID-RANGE EF I. Katsytadze, Kateryna Amosova, Andrey Bezrodniy, Igor Gorda, Nataliya Shishkina, Olha Vasylenko. Bogomolets National Medical University, Kyiv, Ukraine
Ă
Methods: We conducted a case-control study between January 2015 and November 2016. Demographic information, rosacea duration and subtype, smoking history, lipid parameters, blood pressure levels, use of antihypertensive drug, fasting blood glucose (FBG), BMI, family history of coronary artery disease, presence of metabolic syndrome (MS), and presence of insulin resistance (IR), and points of the FRS and SCORE were systematically recorded.
Aim: To compare the effect of Ivabradine (Iv) plus bisoprolol (Bs) and Bs uptitration on arterial elastance (Ea), pulse wave velocity (PWV), augmentation index (AI) and NTproBNP in CAD patients with mid-range EF. Methods: In single-blind, parallel-group study 85 pts < 60 years (55±2,5) in sinus rhythm >70 bpm with CAD (stable angina CCS class I-II), documented MI>3 months, EF 35-45%, treated with Bs 5 mg od, were randomized into 2 groups. In Group 1 (n¼40) Iv was added (5mg bid