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ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS AND METABOLIC SYNDROME IN ASYMPTOMATIC SUBJECTS: ASSESSMENT WITH CORONARY CT ANGIOGRAPHY
E1469 JACC April 5, 2011 Volume 57, Issue 15
VASCULAR DISEASE ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS AND METABOLIC SYNDROME IN ASYMPTOMATIC SUBJECTS: ASSESSMENT WITH CORONARY CT ANGIOGRAPHY ACC Poster Contributions Ernest N. Morial Convention Center, Hall F Sunday, April 03, 2011, 3:30 p.m.-4:45 p.m.
Session Title: Cardiovascular Risk Factors Abstract Category: 8. Vascular Biology/Atherosclerosis/Thrombosis/Endothelium Session-Poster Board Number: 1041-116 Authors: Hwan-Seok Yong, Yoon Kyung Kim, Eun-young Kang, Ok Hee Woo, Korea University Guro Hospital, Seoul, South Korea Background: Although the relationship between metabolic syndrome (MetS) and increased risk of cardiovascular disease has been documented, the association between coronary atherosclerosis on coronary CT angiography (CCTA) and MetS has not been well documented. We analyzed the relationship between MetS and coronary atherosclerosis on CCTA with other cardiovascular risk factors in asymptomatic subjects. Methods: The study group consisted of 645 self referred asymptomatic subjects who had at least one cardiovascular risk factor and underwent CCTA. Presence of coronary plaque and number of involved coronary segments (segment involvement score, SIS) were calculated to assess the plaque burden. Cardiovascular risk factors were also measured. Results: Among 645 subjects, 39% of subjects had plaques in their coronary arteries on CCTA and 26% of subjects had MetS. Prevalence of coronary plaque and SIS were significantly higher in subjects with MetS than without (52.1% vs 34.5%, P<0.0001; 1.22±1.98 vs 0.76±1.49, P=0.006). In the 3 groups classified according to the number of metabolic factors (0, 1~2, 3 or more), presence of plaque and subjects with SIS ≥2 were significantly increased (32.4% vs 36.7% vs 52.1%; 17% vs 19.7% vs 23.7%). Multivariate linear and multiple logistic regression analysis showed that MetS was significantly associated with presence and burden of coronary plaque depicted on CCTA after adjustment of CV risk factors. Conclusions: Metabolic syndrome was associated with the presence and degree of coronary atherosclerosis depicted on CCTA in asymptomatic subjects.
VASCULAR DISEASE ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS AND METABOLIC SYNDROME IN ASYMPTOMATIC SUBJECTS: ASSESSMENT WITH CORONARY CT ANGIOGRAPHY ACC Poster Contributions Ernest N. Morial Convention Center, Hall F Sunday, April 03, 2011, 3:30 p.m.-4:45 p.m.
Session Title: Cardiovascular Risk Factors Abstract Category: 8. Vascular Biology/Atherosclerosis/Thrombosis/Endothelium Session-Poster Board Number: 1041-116 Authors: Hwan-Seok Yong, Yoon Kyung Kim, Eun-young Kang, Ok Hee Woo, Korea University Guro Hospital, Seoul, South Korea Background: Although the relationship between metabolic syndrome (MetS) and increased risk of cardiovascular disease has been documented, the association between coronary atherosclerosis on coronary CT angiography (CCTA) and MetS has not been well documented. We analyzed the relationship between MetS and coronary atherosclerosis on CCTA with other cardiovascular risk factors in asymptomatic subjects. Methods: The study group consisted of 645 self referred asymptomatic subjects who had at least one cardiovascular risk factor and underwent CCTA. Presence of coronary plaque and number of involved coronary segments (segment involvement score, SIS) were calculated to assess the plaque burden. Cardiovascular risk factors were also measured. Results: Among 645 subjects, 39% of subjects had plaques in their coronary arteries on CCTA and 26% of subjects had MetS. Prevalence of coronary plaque and SIS were significantly higher in subjects with MetS than without (52.1% vs 34.5%, P<0.0001; 1.22±1.98 vs 0.76±1.49, P=0.006). In the 3 groups classified according to the number of metabolic factors (0, 1~2, 3 or more), presence of plaque and subjects with SIS ≥2 were significantly increased (32.4% vs 36.7% vs 52.1%; 17% vs 19.7% vs 23.7%). Multivariate linear and multiple logistic regression analysis showed that MetS was significantly associated with presence and burden of coronary plaque depicted on CCTA after adjustment of CV risk factors. Conclusions: Metabolic syndrome was associated with the presence and degree of coronary atherosclerosis depicted on CCTA in asymptomatic subjects.