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Autopsy case of amyloidosis in sudden unexpected death: A case report
Pathology (2014) 46(S2), pp. S45–S140
Posters
Autopsy Pathology: Poster#001 A CASE REPORT ON A 12-YEAR-OLD MALE WITH LEFT EPIDIDYMAL SWELLING SECONDARY TO SCHISTOSOMIASIS Chukwudi Onyeaghana Okani1, Terhemba Nyaga1, Benjamin Samuel Otene1, Francis Ortese Uji2 and Joseph Aondowase Ngbea1 1Department of Histopathology, Benue State University Teaching Hospital, Benue State, and 2General Hospital, Makurdi, Benue State, Nigeria Schistosomiasis, also known as bilharzia or snail fever, is a preventable communicable disease that is prevalent in the developing world. Approximately 200 million people are infested worldwide. In Nigeria, about 20 million people are affected; most of these people are children. Here is a case of schistosomiasis in a 12-year-old male child who presented with one month history of left testicular mass measuring 3.3 2.5 1.0 cm which was associated with dysuria. Surgical exploration revealed a hard mass which was adherent to the epididymis with extension to the posterior pole of the testis. Microscopic examination of the biopsy revealed multifocal areas of chronic granulomatous inflammation around calcified Schistosomiasis haematobium eggs. The patient has remained stable 6 months after surgery. Autopsy Pathology: Poster#002 AN AUTOPSY REVIEW OF SUDDEN UNEXPECTED NATURAL DEATHS IN A SUBURBAN NIGERIAN POPULATION Donatus Sabageh1, Olumuyiwa Eyitayo Pelemo2, Akinwumi Oluwole Komolafe2 and William Olufemi Odesanmi2 1Department of Morbid Anatomy and Histopathology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria, and 2Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria Introduction: The pattern of sudden unexpected natural deaths (SUND) is known to reflect the disease pattern prevalent in any particular geographic location. Cardiovascular, respiratory and central nervous systems are the most common organ systems contributing to SUND. This pattern appears to be changing in Nigeria in response to the changing demographics and lifestyle. It is, therefore, vital to review the causes of SUND in a typical Nigerian population and compare these with what obtains in other places. Materials and methods: Cases of sudden unexpected natural deaths seen at the OAUTHC, Ile-Ife, Nigeria over a 10-year period formed the basis of the study. Results: SUND accounted for 13.4% of all medico-legal autopsies. The male to female ratio was 2.1:1 while the mean age was 43.1 years 19.5 SD. About 54.1% of cases were older than 40 years while only 10.1% were younger than 20 years old. Print ISSN 0031-3025/Online ISSN 1465-3931
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Cardiovascular (28.3%), respiratory (18.2%) and central nervous system (12.6%) disorders were the leading causes of death. Hypertensive heart disease (18.2%), intracerebral haemorrhage (7.5%), chronic glomerulonephritis (6.3%), breast carcinoma (6.3%), bacterial pneumonia (6.3%), aspiration pneumonitis (5.7%) and diabetic ketoacidosis (5.0%) were the leading specific causes. About 83.1% of deaths occurred outside the hospital setting while only 16.9% of deaths occurred during hospital admission. Conclusion: Although hypertension-related disorders constitute a significant proportion of SUND where the pattern is similar to other developing countries and the majority of deaths occur outside the hospital setting. Autopsy Pathology: Poster#003 AUTOPSY CASE OF AMYLOIDOSIS IN SUDDEN UNEXPECTED DEATH: A CASE REPORT Suranarong Srisuwan and Surasit Rotchanakitamnuai Forensic Pathology Department, Central Institute of Forensic Science, Minstry of Justice, Thailand Amyloidosis is a complex disease that can involve many organs and cause end-organ dysfunction. We incidentally encountered a case of systemic amyloidosis in a 52-year-old woman following sudden unexpected death. At autopsy amyloidosis was observed in the heart, liver, spleen, lung, pancreas, adrenal glands, kidneys and pituitary. Histology revealed generalized deposition of hyaline, a Congo red-positive substance, especially in the arterial walls of various organs. The cause of death is cardiopulmonary failure.
Autopsy Pathology: Poster#004 AUTOPSY CASE OF LIPOMA OF THE TUBER CINEREUM AND LOW-LYING BIFURCATION OF THE RIGHT COMMON CAROTID ARTERY A CASE REPORT Suranarong Srisuwan Forensic Pathology Department, Central Institute of Forensic Science, Minstry of Justice, Thailand The intracranial lipomas are rare. Typically occurring in the midline, the most common locations for these tumors are the corpus callosum and cerebellopontine angle. An incidentally encountered case of lipoma of the tuber cinereum in a 21-yearold man was suicidal hanging. He was a death in custody. Postmortem examination revealed a ligature line around the anterior and lateral aspects of the neck. Autopsy revealed a 0.8-cm, well circumscribed, soft, yellow lobulated mass on the ventral surface of the tuber cinereum. Histology examination revealed that this lesion was composed of mature adipose tissue consistent with lipoma. The common carotid artery generally bifurcates into the internal and external carotid arteries at the level of C3-4. This case revealed low-lying bifurcation of the right common carotid artery. The cause of death was hanging.
2014 Royal College of Pathologists of Australasia
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.
Posters
Autopsy Pathology: Poster#001 A CASE REPORT ON A 12-YEAR-OLD MALE WITH LEFT EPIDIDYMAL SWELLING SECONDARY TO SCHISTOSOMIASIS Chukwudi Onyeaghana Okani1, Terhemba Nyaga1, Benjamin Samuel Otene1, Francis Ortese Uji2 and Joseph Aondowase Ngbea1 1Department of Histopathology, Benue State University Teaching Hospital, Benue State, and 2General Hospital, Makurdi, Benue State, Nigeria Schistosomiasis, also known as bilharzia or snail fever, is a preventable communicable disease that is prevalent in the developing world. Approximately 200 million people are infested worldwide. In Nigeria, about 20 million people are affected; most of these people are children. Here is a case of schistosomiasis in a 12-year-old male child who presented with one month history of left testicular mass measuring 3.3 2.5 1.0 cm which was associated with dysuria. Surgical exploration revealed a hard mass which was adherent to the epididymis with extension to the posterior pole of the testis. Microscopic examination of the biopsy revealed multifocal areas of chronic granulomatous inflammation around calcified Schistosomiasis haematobium eggs. The patient has remained stable 6 months after surgery. Autopsy Pathology: Poster#002 AN AUTOPSY REVIEW OF SUDDEN UNEXPECTED NATURAL DEATHS IN A SUBURBAN NIGERIAN POPULATION Donatus Sabageh1, Olumuyiwa Eyitayo Pelemo2, Akinwumi Oluwole Komolafe2 and William Olufemi Odesanmi2 1Department of Morbid Anatomy and Histopathology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria, and 2Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria Introduction: The pattern of sudden unexpected natural deaths (SUND) is known to reflect the disease pattern prevalent in any particular geographic location. Cardiovascular, respiratory and central nervous systems are the most common organ systems contributing to SUND. This pattern appears to be changing in Nigeria in response to the changing demographics and lifestyle. It is, therefore, vital to review the causes of SUND in a typical Nigerian population and compare these with what obtains in other places. Materials and methods: Cases of sudden unexpected natural deaths seen at the OAUTHC, Ile-Ife, Nigeria over a 10-year period formed the basis of the study. Results: SUND accounted for 13.4% of all medico-legal autopsies. The male to female ratio was 2.1:1 while the mean age was 43.1 years 19.5 SD. About 54.1% of cases were older than 40 years while only 10.1% were younger than 20 years old. Print ISSN 0031-3025/Online ISSN 1465-3931
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Cardiovascular (28.3%), respiratory (18.2%) and central nervous system (12.6%) disorders were the leading causes of death. Hypertensive heart disease (18.2%), intracerebral haemorrhage (7.5%), chronic glomerulonephritis (6.3%), breast carcinoma (6.3%), bacterial pneumonia (6.3%), aspiration pneumonitis (5.7%) and diabetic ketoacidosis (5.0%) were the leading specific causes. About 83.1% of deaths occurred outside the hospital setting while only 16.9% of deaths occurred during hospital admission. Conclusion: Although hypertension-related disorders constitute a significant proportion of SUND where the pattern is similar to other developing countries and the majority of deaths occur outside the hospital setting. Autopsy Pathology: Poster#003 AUTOPSY CASE OF AMYLOIDOSIS IN SUDDEN UNEXPECTED DEATH: A CASE REPORT Suranarong Srisuwan and Surasit Rotchanakitamnuai Forensic Pathology Department, Central Institute of Forensic Science, Minstry of Justice, Thailand Amyloidosis is a complex disease that can involve many organs and cause end-organ dysfunction. We incidentally encountered a case of systemic amyloidosis in a 52-year-old woman following sudden unexpected death. At autopsy amyloidosis was observed in the heart, liver, spleen, lung, pancreas, adrenal glands, kidneys and pituitary. Histology revealed generalized deposition of hyaline, a Congo red-positive substance, especially in the arterial walls of various organs. The cause of death is cardiopulmonary failure.
Autopsy Pathology: Poster#004 AUTOPSY CASE OF LIPOMA OF THE TUBER CINEREUM AND LOW-LYING BIFURCATION OF THE RIGHT COMMON CAROTID ARTERY A CASE REPORT Suranarong Srisuwan Forensic Pathology Department, Central Institute of Forensic Science, Minstry of Justice, Thailand The intracranial lipomas are rare. Typically occurring in the midline, the most common locations for these tumors are the corpus callosum and cerebellopontine angle. An incidentally encountered case of lipoma of the tuber cinereum in a 21-yearold man was suicidal hanging. He was a death in custody. Postmortem examination revealed a ligature line around the anterior and lateral aspects of the neck. Autopsy revealed a 0.8-cm, well circumscribed, soft, yellow lobulated mass on the ventral surface of the tuber cinereum. Histology examination revealed that this lesion was composed of mature adipose tissue consistent with lipoma. The common carotid artery generally bifurcates into the internal and external carotid arteries at the level of C3-4. This case revealed low-lying bifurcation of the right common carotid artery. The cause of death was hanging.
2014 Royal College of Pathologists of Australasia
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.