- Email: [email protected]
Barbituric acid dermatitis with photosensitization
420
TIIk:
JOURNAL
OF
ALLERGY
As determinetl by t,he serum dilution method, an wrre also less aPter trcatruont. increase in skin-wnsitizing antilwdy was flwnd in t,welro sera after treatment, am1 in all thirteen sera when the nwtralizatiou method was used. Thr presence of thr blocking or reaction-inhibiting antibody was observed in all thirlecu post-trratnrent The specificdit> scra by the USC of the method that has been described by T20rrlws. of this antibody was also confirmed. Another way of testing for the blocking antibody is dewribed. It is a serum dilution method, in which a fixed amount, of ragweed extract is addetl to heatetl before- and after-treatment serum, and serial dilutions are macle. The mixtures are used to test sites previowly mndc wit11 unlleatrd serum from an untrentrtl ww of ragweed hay fever. Homr~rcr, tlw results ohtainetl with this method were uot Thrw always in accordance with those obtainetl with the neutralization methwl. discrepancies were explained when it wits found that, although xl1 the wra gave positive passive transfer rcactiow to Fraction I of a ragwe extract (albuminprecipitated hy half saturation with ammonium sulfate from a wat-er extract of lo\\ Tagweed pollen), only six rrac?ed also to Fraction 2 (preApitatet1 by completc~ saturation after thr removal of Fraction 1)) and, following treat,ment, blocking Consequently, in tenting antibody for Fraction 2 was formed in one serum only. for blocking antibody by this serial dilution method, the results obtained drpn~tl~l upon the way in whic~h thp serum used to sensitize cutaneous sites reacted to the two nnt,igrnic fractions of the ragweed pollen. Clinicval rrsults were equally satisfact,ory in patients sensitive to Fraction 1 as wrnpared to patients sensitive to both fractions, but those who were sensitive to Fraction 2 and did not form blocking antibody for that fraction did not develop tolcmnce to large doses of ragweed pollen extract and had more constitutional i-C’actions than did those who were sensitive to only one fraction and developed an nntibody inactivating that fraction.
Dermatology
Barbituric Acid Dermatitis ?N. A. 36: 484, 1939.
With Photosensitization.
Stryker,
G. V.:
.T. Missouri
The Cyear-old patient discussed in this report had been given barbiturates for six weeks for epilepsy. Ten days before she was seen an wuption developed on of the the face and soon spread to the rest of the body. Rftcr the administration drug was stopped, the eruption subsided rapidly. houw Three months later the eruption suddenly recurred, within twenty-four The dermatitis was sharply lirnitetl after exposure t,o the sun in the early spring. to the exposed arcas. Small quantities of barbital and porphyrin, which were found Thew in the urine at the time of the recurrence, gradually decreased in quantity. was no recurrence in the next four months.
Skip, Conjunctival, and Scleral Reactions in the Course of Therapy With Sulfathiazole. Haviland, J. W., and I,ong, P. H.: Bull. Johns Hopkins Hosp. 66: 313, 1940. The authors describe a new type of waction to sulfathia~ole, n reaction which has not been reported after administration of other members of the sulfonamide Of seventy-eight patients treated with sulfathiazole, six presented congroup. junctival and scleral injection, restricted mainly to lhe exposed portion of the bulbnr
TIIk:
JOURNAL
OF
ALLERGY
As determinetl by t,he serum dilution method, an wrre also less aPter trcatruont. increase in skin-wnsitizing antilwdy was flwnd in t,welro sera after treatment, am1 in all thirteen sera when the nwtralizatiou method was used. Thr presence of thr blocking or reaction-inhibiting antibody was observed in all thirlecu post-trratnrent The specificdit> scra by the USC of the method that has been described by T20rrlws. of this antibody was also confirmed. Another way of testing for the blocking antibody is dewribed. It is a serum dilution method, in which a fixed amount, of ragweed extract is addetl to heatetl before- and after-treatment serum, and serial dilutions are macle. The mixtures are used to test sites previowly mndc wit11 unlleatrd serum from an untrentrtl ww of ragweed hay fever. Homr~rcr, tlw results ohtainetl with this method were uot Thrw always in accordance with those obtainetl with the neutralization methwl. discrepancies were explained when it wits found that, although xl1 the wra gave positive passive transfer rcactiow to Fraction I of a ragwe extract (albuminprecipitated hy half saturation with ammonium sulfate from a wat-er extract of lo\\ Tagweed pollen), only six rrac?ed also to Fraction 2 (preApitatet1 by completc~ saturation after thr removal of Fraction 1)) and, following treat,ment, blocking Consequently, in tenting antibody for Fraction 2 was formed in one serum only. for blocking antibody by this serial dilution method, the results obtained drpn~tl~l upon the way in whic~h thp serum used to sensitize cutaneous sites reacted to the two nnt,igrnic fractions of the ragweed pollen. Clinicval rrsults were equally satisfact,ory in patients sensitive to Fraction 1 as wrnpared to patients sensitive to both fractions, but those who were sensitive to Fraction 2 and did not form blocking antibody for that fraction did not develop tolcmnce to large doses of ragweed pollen extract and had more constitutional i-C’actions than did those who were sensitive to only one fraction and developed an nntibody inactivating that fraction.
Dermatology
Barbituric Acid Dermatitis ?N. A. 36: 484, 1939.
With Photosensitization.
Stryker,
G. V.:
.T. Missouri
The Cyear-old patient discussed in this report had been given barbiturates for six weeks for epilepsy. Ten days before she was seen an wuption developed on of the the face and soon spread to the rest of the body. Rftcr the administration drug was stopped, the eruption subsided rapidly. houw Three months later the eruption suddenly recurred, within twenty-four The dermatitis was sharply lirnitetl after exposure t,o the sun in the early spring. to the exposed arcas. Small quantities of barbital and porphyrin, which were found Thew in the urine at the time of the recurrence, gradually decreased in quantity. was no recurrence in the next four months.
Skip, Conjunctival, and Scleral Reactions in the Course of Therapy With Sulfathiazole. Haviland, J. W., and I,ong, P. H.: Bull. Johns Hopkins Hosp. 66: 313, 1940. The authors describe a new type of waction to sulfathia~ole, n reaction which has not been reported after administration of other members of the sulfonamide Of seventy-eight patients treated with sulfathiazole, six presented congroup. junctival and scleral injection, restricted mainly to lhe exposed portion of the bulbnr