Benign and malignant tumors GnRH analogues in cancer and human reproduction, volume 3

Benign and malignant tumors GnRH analogues in cancer and human reproduction, volume 3

BOOK REVIEWS Updates on GnRH for Research and Practice GnRH Analogues in Reproduction and Gynecology: GnRH Analogues in Cancer and Human Reproduction,...

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BOOK REVIEWS Updates on GnRH for Research and Practice GnRH Analogues in Reproduction and Gynecology: GnRH Analogues in Cancer and Human Reproduction, volume 2 Edited by B.H. Vickery and B. Lunenfeld. Dordrecht, Kluwer, 1990, $65.00, Dfr. 125.00, f35.00 (xxviii+1 77 pages), ISBN O-792-38929-8.

Benign and Malignant Tumors GnRH Analogues in Cancer and Human Reproduction,volume 3 Edited by B.H.Vickery and B. Lunenfeld. Dordrecht, Kluwer, 1990, $85.00, Dfr. 165.00, f4500(xxviii+222 pages), ISBN

0-792-38930-l. These books represent two volumes in the four-volume series, GnRH Analogues in Cancer and Human Reproduction, a distillation of the presentations of the international symposium of the same name organized by one of the editors, Dr. Bruno Lunenfeld, and held in Geneva, Switzerland, in February 1988. These proceedings represent a series of research papers presented at the symposium by many of the worlds foremost investigators in this rapidly advancing field. Consequently these books provide researchers and interested clinicians with a comprehensive overview of gynecologic and oncologic topics on this important class of compounds. Basic science aspects and pediatric applications are presented in the two other volumes in

the series. These books are intended as an interdisciplinary and comprehensive summary of current work in this clinically important area. GnRH Analogues in Reproduction and Gynecology contains 18 chapters. In keeping with contemporary clinical application, seven chapters are devoted to endometriosis, one to abnormal uterine bleeding, three to ovulation induction, one to polycystic ovarian disease, five to in vitro fertilization and one to the GnRH antagonists. Benign and Malignant Tumors consists of 20 chapters, emphasizing the well-known applications to uterine fibroids and prostate cancer; however, potentially useful applications to ovarian carcinoma, malignant endometriosis, breast and pancreatic cancer, and even FSH-secreting tumors receive attention. The editors have organized each volume well. Although each chapter consists of a separate research paper, many of the authors have included comprehensive literature reviews and summaries or prior pertinent work as part of the introduction to their chapter. The graphics are unusually clear and easy to follow, and many chapters contain helpful schematics of protocols or physiologic points. Most chapters contain a succinct summary as a concluding section. The strength of these volumes lies in the high quality of the work presented. The authors not only review their investigations clearly and objectively, but also

the majority of the contributors place their studies in a proper historic and research framework. The editors include an introduction to the entire series in volume 1. However, introductory or concluding comments are sadly absent from each of the individual volumes. The thoughts of the editors with their unique perspectives and insights could have provided a unifying theme to each volume as well as to the series as a whole. Overall, the editors are to be praised for organizing and compiling a remarkable array of talented authors and important research. These books provide a well-organized, nicely balanced synthesis of recent research into the clinical applications of the G&H analogues. Since these volumes represent the compilation of a series of studies, they are most appropriate for researchers or clinicians with a special interest in this area. The GnRH analogues are rapidly becoming an important addition to the pharmacologic armamentarium of the gynecologic oncologist and endocrinologist, and these volumes provide a useful, readable summary of current and future applications TJZM of these agents.

Mark D. Hornstein Department of Obstetrics and Gynecology Brigham and Women’s Hospital Harvard Medical School Boston, MA 02115, USA

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