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Bioconversions: Nouveau procédé de bioconversion microbienne (JM Nicaud et al, FR) CNRS N° 2734843, FR.
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W 748867, EP.
Marek's Disease Virus adapted to growth on an avian continuous cell line, in particular to the quail cell line QT-35, to the growing of thus adapted viruses on avian continuous cell cultures, and to vaccines containing such viruses.
Diagnostic > Methode de diagnostic de la schizophrenie (C Laurent et ai, FR) Rh6ne-Poulenc Rorer et les inventeurs W WO 96/34980, PCT. La presente invention concerne une methode de diagnostic de la schizophrenie basee sur la detection in vitro de la presence de l'allele Ep du microsatellite HUMTHOl dans Ie gene TH. L'invention concerne egalernent les amorces utilisees pour la mise en ceuvre de cette methode.
Vi rus > Non-pathogenic strains of HIV-1 and methods for detecting same (OA McPhee et ai, AU) Actract Pty Ltd, Macfarlane Burnet Syndicate NO.1 Pty Ltd and the inventors W WO 96/36699, PCT. The methods of the present inventionare particularlyuseful in determining the likelihood of an individual who is seropositive for HIV-l developing AIDSor AIDS-related symptoms. The present invention further contemplates therapeutic compositions for the treatment and prophylaxis of AIDS and AIDS-related disorders.
Systeme immunitaire > Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function (A Edge, JR Gunsalus, US) Diacrin Inc W WO 96/37602, PCT. The porcine hepatocytes can be either hepatocytes isolated from adult, immature, or embryonic swine. The porcine hepatocytes can be modified to be suitable for transplantation into a xenogenic subject, for example, by altering an antigen on the 44 BIOFUTUR 164 • Fevrier 1997
cell surface which is capable of stimulating an immune response against the cell in the subject. > Compositions and methods for inhibiting xenograft refection (DV Cramer etal, US) Cedars-Sinai Medical Center and the inventors N° WO 96136358. PCT. ... compositions and methods useful to inhibit antibody-mediated xenograft rejection by xenogeneic transplant recipients, ... compositions which induce antibody-mediated xenograft rejection. Methods for isolating antigen expressed by endothelial cells ofaxenograft and which induces antibody-mediated rejection of xenografts are also provided.
Apoptose > Human inhibitor of apoptosis gene 1 (WW He et ai, US) Human Genome Sciences Inc and the inventors N° WO 96/35703, PCT. A human inhibitor of apoptosis polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide, ... methods for utilizing such polypeptide for the treatment of degenerative diseases, rheumatoid arthritis, septic shock, as an antiviral defense mechanism and to prevent the death of cells during trauma and strokes.
Maladies i nfe cti euses > Hybrid molecules bet-
ween heat-labile enterotoxin and cholera toxin B subunits (J Holmgren, MR Lebens, SE) The inventors W WO 96/34893, PCT. ... also a vaccine, eg against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.
> Methods of use of phthalocyanines to inactivate blood borne parasites (P Gottlieb et ai, US) New York Blood Center Inc and the inventors N° WO 96/36704, PCT.
... a method for inactivating parasites in blood cell-containing compositions by incubating a mixture of the blood cell-containing composition, a phthalocyanine dye and a quencher and optionally irradiating this mixture with red light. This invention relates to a method of sterilizing blood cell-containing compositions which contain lipid enveloped viruses and blood borne parasites.
> Method of treating cartilaginous diseases with genetically modified chondrocytes (VM Baragi, BJ Roessler, US) Warner-Lambert CO N° WO 96/34955, PCT. A method of treating an arthritic condition comprising: subjecting a patient in need thereof to an effective amount of recombinant chondrocytes comprising articular chondrocytes recornbinantly modified with a gene which has a therapeutic or prophylactic activity for an arthritic condition.
Systeme de deltvr anc e
> Oral insulin delivery (BE
Burnside et ai, US) Pharmavene Inc W WO 96/37215, PCT. A pharmaceutical preparation for oral insulin delivery comprising a stable, hudrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcoholthereof dispersed in an aqueous phase or having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof.
CHIMIE-GENIE EI\L IIVlATIOUE Bioconversions > Nouveau procede de bioconversion microbienne (JM Nicaud et ai, FR) CNRS
W 2734843, FR.
... utilisation d'une (ou plusieurs) souche(s) de microorganismes auxotrophes pour au moins un compose determine, dans Ie cadre de
la mise en ceuvre de procedes de bioconversion microbienne de substrars determines.
> Procede de production
de vanilline par bioconversion de precurseurs benzeniques (B Audras, J More, FR) Orsan et les inventeurs W WO 96/34971, PCT. ... en particulier l'acide ferulique ou Ie ferulate de sodium par culture immobilisee de microorganismes actinornycetes, notamment du genre Streptomyces.
> Recombinant baculovirus insecticides (BF McCutchen, US) EI Du Pont de Nemours and Co and the inventors W WO 96/36712, PCT. ... recombinant baculoviruses that have been engineered to affort optimal expression of genes encoding insect-selective neurotoxins. > Casein-based sprayable fonnulation for pest control (BS Shasha et ai, US) The Secretary of Agriculture of USA, Biotechnology Research and Development Corp N° WO 96/37106, PCT. A process of delivering a pest control agent in a sprayable pest control formulation. The present invention also provides a method of protecting a pest control agent from environmental conditions, such as a washoff and ultraviolet degradation.
Depollution > Purification system for groundwater or wastewater, biochemical reactor and liquid-transport stirring apparatus (M Matsumura et ai, JP) Biomaterial Co Ltd and M Matsumura W 745562, EP.
> Aluminium resistance gene (RC Gardner et ai,
NZ)
Auckland Uniservices Ltd and the inventors W WO 96/34959, PCT.
A method of isolating genes conferring resistance to aluminium is provided and two particular aluminium tolerant genes are described.
W 748867, EP.
Marek's Disease Virus adapted to growth on an avian continuous cell line, in particular to the quail cell line QT-35, to the growing of thus adapted viruses on avian continuous cell cultures, and to vaccines containing such viruses.
Diagnostic > Methode de diagnostic de la schizophrenie (C Laurent et ai, FR) Rh6ne-Poulenc Rorer et les inventeurs W WO 96/34980, PCT. La presente invention concerne une methode de diagnostic de la schizophrenie basee sur la detection in vitro de la presence de l'allele Ep du microsatellite HUMTHOl dans Ie gene TH. L'invention concerne egalernent les amorces utilisees pour la mise en ceuvre de cette methode.
Vi rus > Non-pathogenic strains of HIV-1 and methods for detecting same (OA McPhee et ai, AU) Actract Pty Ltd, Macfarlane Burnet Syndicate NO.1 Pty Ltd and the inventors W WO 96/36699, PCT. The methods of the present inventionare particularlyuseful in determining the likelihood of an individual who is seropositive for HIV-l developing AIDSor AIDS-related symptoms. The present invention further contemplates therapeutic compositions for the treatment and prophylaxis of AIDS and AIDS-related disorders.
Systeme immunitaire > Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function (A Edge, JR Gunsalus, US) Diacrin Inc W WO 96/37602, PCT. The porcine hepatocytes can be either hepatocytes isolated from adult, immature, or embryonic swine. The porcine hepatocytes can be modified to be suitable for transplantation into a xenogenic subject, for example, by altering an antigen on the 44 BIOFUTUR 164 • Fevrier 1997
cell surface which is capable of stimulating an immune response against the cell in the subject. > Compositions and methods for inhibiting xenograft refection (DV Cramer etal, US) Cedars-Sinai Medical Center and the inventors N° WO 96136358. PCT. ... compositions and methods useful to inhibit antibody-mediated xenograft rejection by xenogeneic transplant recipients, ... compositions which induce antibody-mediated xenograft rejection. Methods for isolating antigen expressed by endothelial cells ofaxenograft and which induces antibody-mediated rejection of xenografts are also provided.
Apoptose > Human inhibitor of apoptosis gene 1 (WW He et ai, US) Human Genome Sciences Inc and the inventors N° WO 96/35703, PCT. A human inhibitor of apoptosis polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide, ... methods for utilizing such polypeptide for the treatment of degenerative diseases, rheumatoid arthritis, septic shock, as an antiviral defense mechanism and to prevent the death of cells during trauma and strokes.
Maladies i nfe cti euses > Hybrid molecules bet-
ween heat-labile enterotoxin and cholera toxin B subunits (J Holmgren, MR Lebens, SE) The inventors W WO 96/34893, PCT. ... also a vaccine, eg against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.
> Methods of use of phthalocyanines to inactivate blood borne parasites (P Gottlieb et ai, US) New York Blood Center Inc and the inventors N° WO 96/36704, PCT.
... a method for inactivating parasites in blood cell-containing compositions by incubating a mixture of the blood cell-containing composition, a phthalocyanine dye and a quencher and optionally irradiating this mixture with red light. This invention relates to a method of sterilizing blood cell-containing compositions which contain lipid enveloped viruses and blood borne parasites.
> Method of treating cartilaginous diseases with genetically modified chondrocytes (VM Baragi, BJ Roessler, US) Warner-Lambert CO N° WO 96/34955, PCT. A method of treating an arthritic condition comprising: subjecting a patient in need thereof to an effective amount of recombinant chondrocytes comprising articular chondrocytes recornbinantly modified with a gene which has a therapeutic or prophylactic activity for an arthritic condition.
Systeme de deltvr anc e
> Oral insulin delivery (BE
Burnside et ai, US) Pharmavene Inc W WO 96/37215, PCT. A pharmaceutical preparation for oral insulin delivery comprising a stable, hudrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcoholthereof dispersed in an aqueous phase or having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof.
CHIMIE-GENIE EI\L IIVlATIOUE Bioconversions > Nouveau procede de bioconversion microbienne (JM Nicaud et ai, FR) CNRS
W 2734843, FR.
... utilisation d'une (ou plusieurs) souche(s) de microorganismes auxotrophes pour au moins un compose determine, dans Ie cadre de
la mise en ceuvre de procedes de bioconversion microbienne de substrars determines.
> Procede de production
de vanilline par bioconversion de precurseurs benzeniques (B Audras, J More, FR) Orsan et les inventeurs W WO 96/34971, PCT. ... en particulier l'acide ferulique ou Ie ferulate de sodium par culture immobilisee de microorganismes actinornycetes, notamment du genre Streptomyces.
> Recombinant baculovirus insecticides (BF McCutchen, US) EI Du Pont de Nemours and Co and the inventors W WO 96/36712, PCT. ... recombinant baculoviruses that have been engineered to affort optimal expression of genes encoding insect-selective neurotoxins. > Casein-based sprayable fonnulation for pest control (BS Shasha et ai, US) The Secretary of Agriculture of USA, Biotechnology Research and Development Corp N° WO 96/37106, PCT. A process of delivering a pest control agent in a sprayable pest control formulation. The present invention also provides a method of protecting a pest control agent from environmental conditions, such as a washoff and ultraviolet degradation.
Depollution > Purification system for groundwater or wastewater, biochemical reactor and liquid-transport stirring apparatus (M Matsumura et ai, JP) Biomaterial Co Ltd and M Matsumura W 745562, EP.
> Aluminium resistance gene (RC Gardner et ai,
NZ)
Auckland Uniservices Ltd and the inventors W WO 96/34959, PCT.
A method of isolating genes conferring resistance to aluminium is provided and two particular aluminium tolerant genes are described.