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Bioprocess monitoring and control
J. Steroid Biochem. Molec. Biol. VoL 46, No. 5, p. 641, 1993
Pergamon Press Ltd. Printed in Great Britain
BOOK REVIEWS Plant Cell and Tissue Culture in Liquid Systems. By G. F. PAYS, V. BRISOI, C. L. PmNC~ and M. L. SHULER. Published 1991 by Hanser Publishers, Munich. ISBN: 3-446-15830-8. No. of pages: 348. Price (hardback): DM 144; US$ 95.00; £ 55.00. This book is designed to bridge the gap between scientists and engineers working in the field and to provide a cohesive text exploring the use of Plant Cell and Tissue Culture for the production of natural products. Such a text is necessary because the field has evolved from research conducted by diverse groups of scientists and engineer, each pursuing their divergent interests and developing their own terminology. The goal is to bring these divergent ideas togethe~ in a single, cohesive treatment. Therefore, after an introductory outline of the motivation for considering plant cell and tissue culture for commercial application, which also indicates the non-technical (e.g. economic) limitations to practical applications, the book provides the biological background needed to understand the interaction between the cells and their environment and the engineering background to explain the critical role of gas transfe~ in biureactor systems. The main part then describes the reasoning and technical appoaches used for culturing cells at different levels of morphological organization as well as some strategies which have recently proven useful in certain cases.
Bioprocess Monitoring n d Control Edited by M.-N. A. PONS. Published 1991 by Hanser Publishers, Munich. ISBN: 3-06-15819-7. No. of pages: 374. Price (hardback): DM 148; US$ 95.00; £ 56.00. This hook addresses bioprocess engineers and life science-trained biotechnologists who are not specialists in process control and who seek information about new devices and edvanc~l control techniques for solving problems. It also serves control engineers who are used to elassic4d problems in mechanical, electrical, or chemical engineering but may not be familiar with the ~ c s of non-linear, time-dependent bioprocesses, which are difficult to instrument. The first comprehensive volume on biopmcess automation and control starts with development and analysis of control structure, its scope starts with biosensors, the hottleneck, which are stressed with the critical descriptions of available devices. Underlying soft sensor estimation techniques are outlined in addition to techniques for use of derived information. Illustrated industrial applications treat hoth low level control loops (temperature, pH, etc.) and high level control strategies (setpoint optimization, optimal trajectories, adaptive control, etc.). In his foreword, Dr Daniel R. Omstead of the R. W. Johnson Pharmaceutical Research Institute notes that the small international team of authors detail "each of the required areas in a thorough and complete manner, and provide an important source of information for hoth the recently introduced user of computer controlled fermentation systems as well as the accompfished practitioner".
Progress in Membrane Bioteelmology. By J. GOMEZ-I~P.NANDe2,D. C3tAPMANand L. PAC~a. Published 1991 by Birkhiiuser Verlag, Switzerland. ISBN: 3-7643-2666-2. No. of pages: 352. Price (hardback): SFr 98; DM 118. Some of the latest developments in the growing field of membrane biotechnology are brought togethe~ in this hook• which includes contributions from leading experts on basic and appfied topics related to biomembrenes and the developing technologies springing from rids subject. The basic topics include ix~fien-lipid intaractinns, platelet aggregating factor and viral fusion. The technological chapte~ contain discussions on liposomes for drug delivery, blood surrogates and immunofiposomes, and liposomes fur cm'tTing antigens and adjuvants. Chapters are also included on the use of lipophific and hydrophilic antioxidants in the protection of membrane lipids and lipoproteins. The study of lipi& and hydrophobic proteins of pulmonary surfactant for the treatment of Respiratory Distress Syndrome in premature babies is also discussed. The development of new biomaterials based on biomembrane mimicaT, the kinetics of antibody binding to model membranes with haematocompatibility characteristics and hollow fiber biomactors are among the exciting developments in this field which are described. This hook gives a broad and excellent overview and is of interest to biocbernists, biophysicists, pharmaceutical chemists, biomaterials scientists and medical doctors interested in keeping abreast of progress in this field and the manner in which it links with their own specialities.
641
Pergamon Press Ltd. Printed in Great Britain
BOOK REVIEWS Plant Cell and Tissue Culture in Liquid Systems. By G. F. PAYS, V. BRISOI, C. L. PmNC~ and M. L. SHULER. Published 1991 by Hanser Publishers, Munich. ISBN: 3-446-15830-8. No. of pages: 348. Price (hardback): DM 144; US$ 95.00; £ 55.00. This book is designed to bridge the gap between scientists and engineers working in the field and to provide a cohesive text exploring the use of Plant Cell and Tissue Culture for the production of natural products. Such a text is necessary because the field has evolved from research conducted by diverse groups of scientists and engineer, each pursuing their divergent interests and developing their own terminology. The goal is to bring these divergent ideas togethe~ in a single, cohesive treatment. Therefore, after an introductory outline of the motivation for considering plant cell and tissue culture for commercial application, which also indicates the non-technical (e.g. economic) limitations to practical applications, the book provides the biological background needed to understand the interaction between the cells and their environment and the engineering background to explain the critical role of gas transfe~ in biureactor systems. The main part then describes the reasoning and technical appoaches used for culturing cells at different levels of morphological organization as well as some strategies which have recently proven useful in certain cases.
Bioprocess Monitoring n d Control Edited by M.-N. A. PONS. Published 1991 by Hanser Publishers, Munich. ISBN: 3-06-15819-7. No. of pages: 374. Price (hardback): DM 148; US$ 95.00; £ 56.00. This hook addresses bioprocess engineers and life science-trained biotechnologists who are not specialists in process control and who seek information about new devices and edvanc~l control techniques for solving problems. It also serves control engineers who are used to elassic4d problems in mechanical, electrical, or chemical engineering but may not be familiar with the ~ c s of non-linear, time-dependent bioprocesses, which are difficult to instrument. The first comprehensive volume on biopmcess automation and control starts with development and analysis of control structure, its scope starts with biosensors, the hottleneck, which are stressed with the critical descriptions of available devices. Underlying soft sensor estimation techniques are outlined in addition to techniques for use of derived information. Illustrated industrial applications treat hoth low level control loops (temperature, pH, etc.) and high level control strategies (setpoint optimization, optimal trajectories, adaptive control, etc.). In his foreword, Dr Daniel R. Omstead of the R. W. Johnson Pharmaceutical Research Institute notes that the small international team of authors detail "each of the required areas in a thorough and complete manner, and provide an important source of information for hoth the recently introduced user of computer controlled fermentation systems as well as the accompfished practitioner".
Progress in Membrane Bioteelmology. By J. GOMEZ-I~P.NANDe2,D. C3tAPMANand L. PAC~a. Published 1991 by Birkhiiuser Verlag, Switzerland. ISBN: 3-7643-2666-2. No. of pages: 352. Price (hardback): SFr 98; DM 118. Some of the latest developments in the growing field of membrane biotechnology are brought togethe~ in this hook• which includes contributions from leading experts on basic and appfied topics related to biomembrenes and the developing technologies springing from rids subject. The basic topics include ix~fien-lipid intaractinns, platelet aggregating factor and viral fusion. The technological chapte~ contain discussions on liposomes for drug delivery, blood surrogates and immunofiposomes, and liposomes fur cm'tTing antigens and adjuvants. Chapters are also included on the use of lipophific and hydrophilic antioxidants in the protection of membrane lipids and lipoproteins. The study of lipi& and hydrophobic proteins of pulmonary surfactant for the treatment of Respiratory Distress Syndrome in premature babies is also discussed. The development of new biomaterials based on biomembrane mimicaT, the kinetics of antibody binding to model membranes with haematocompatibility characteristics and hollow fiber biomactors are among the exciting developments in this field which are described. This hook gives a broad and excellent overview and is of interest to biocbernists, biophysicists, pharmaceutical chemists, biomaterials scientists and medical doctors interested in keeping abreast of progress in this field and the manner in which it links with their own specialities.
641