Cerebriform intradermal nevus

Posters - Phomacologg

tavirus, although gastroenteritis or intestinal symptoms had not occurred before or concurrently with the skin eruption. Thus, it is questionable if our finding was a coexistent or causative event in the pathogenesis of GCS. In 1988 Patrizi et al reported Rotavirus infection in two cases of papulovesicular acrolocated eruption. On the basis of this additional case, a fecal culture is advisable in all cases of GCS to confirm if Rotavirus can be added to the list of viruses which can cause GCS, particularly in the first two years of life.

IP350

Cerebriform

intradermal

M.D. Valari’. K. Aroni’. A. lordanidou’, ‘Departmerrt of Dermatology~ Hospital, Athens; ‘Delxtrtrnent Athetrs. Athens. Greece

nevus

Vesiculo-pustular colitis in a child

eruption

bation of UC and parallels the course of the bowel disease. One case was associated with Crohn’s disease. The differential diagnosis include drug-associated eruptions, viral and bacterial cutaneous infections, Ig A pemphigus, pyoderma gangrenosum and Sweet’s syndrome, subcornea pusmlar dermatosis, pustular vasculitis. and papulo-pustular lesions associated with intestinal bypass surgery. Pustular eruption of UC and pyoderma gangrenosum lie within the spectrum of neutrophilic dermatoses and may overlap. It is important to know that a generalized vesiculo-pustular eruption in childhood may be a reactive process rather than an infectious one and may be a presenting sign of an underlying inflammatory bowel1 disease.

E. Tsgaroni”.

“A. Sopbia ” Cbildrert ‘s of Pathology. University

of

The intradermal nevocytic nevus of the scalp which is referred as cerebriform intradermal nevus (GIN) is a very rare skin lesion. It is usually characterized by folds and furrows in a gyrate appearance to the scalp, resembling cutis verticis gyrata. A 5 year old boy presented with a large mass located on the scalp. At birth a plaque of alopecia was noticed which during childhood became gradually more extensive and raised. On examination he had a large hairless, flesh-colored lesion formed folds and furrows, extending mainly over the parieto-occipital scalp. The rest of the clinical examination was normal. Magnetic resonance imaging of the brain demonstrated the cutaneous folds of the GIN; otherwise wsa unremarkable. Skin biopsies showed clusters of nevus cells in the upper dermis and the lower dermis dominated by neuroid tissue. Immunohistochemical staining with S-100 protein and HMB-45 were positive. P53 protein showed no staining. Following the diagnosis of CIN, excision and plastic reconstruction of the involved area were performed. An early age diagnosis and treatment of the CIN, minimize the emotional trauma and the potential risk of development of malignant melanoma. P351 El

S261

and drug therapSv

of ulcerative

J. Castanet, J.-Ph. Lacour, C. Perrin, C. Tordjman, R. Mariani, J.P. Ortonne. H6pital I’Axhet, Nice. France We report the case of a child who presented a generalized eruption of sterile neutrophilic pustules in association with the onset of ulcerative colitis (UC). A 12-year-old girl had a one month history of diarrhea and hypogastric cramping. She had fever and generalized vesiculopustular lesions and complained of pain in both ankles. Bacterial and viral cultures were sterile. Colonoscopic examination and microscopic examination of the colon were consistent with the diagnosis of UC. Histologic examination of a skin lesion showed a unilocular pustule with neutrophils and a mild inflammatory infiltrate. Direct immunofluorescence microscopy studies were negative. 20 mg/day of oral prednisolone, four times daily of 250 mg of oral mesalazine and daily enemas resulted in complete resolution of the symptoms over a ‘I-day period. The pustular eruption of UC is characterized by a widespread sterile neutrophilic pustular eruption triggered by an exacer-

Pharmacology and drug therapy I P352

Ranking of betamethasone, clobetasol clobetasone by skin blanching and calorimetry

and

C.W. van Haselen’. P.G.H. Mulder?, W.A. van Vloten’. ‘University Hospital, The Netberlarrds

Utrecht;

‘Erasmus

University

Rottenlam.

Objective: To prove equivalence of betamethasone in a nonalcoholic form (emulsion) as compared to the cream and lo rank them among clobetasol and clobetasone. Methods: On the forearms of I2 healthy volunteers, betamethasone cream (bmc) and emulsion (bme), clobetasone cream (cnc), clobetasol cream (clc). placebo emulsion (bpe) were applied in a non-occluded test. Five measurements were performed using visual grading and calorimetry. Results: With visual grading blanching was equivalent for bmc and bme (90% symmetric confidence interval -14.4 to 14.4). Significant less blanching was found for bme as compared to clc (p < O.OOS), and bmc and clc (p < 0.05), and significant more blanching was found for bme as compared to cnc (p < 0.005) and bmc as compared to cnc (p -z 0.001). With calorimetry the value for color (spectrum red-green) corresponded best with the visual score and was least dependent of the localisation as compared to the value for relative brightness. Conclusion: Equivalence in blanching was proved for bmc and bme. Visual blanching score was superior in ranking the corticosteroids as compared to calorimetry. I P353

Oral isotretinoin therapy in two cases with lupus milliaris disseminatus faciei

S. Bahadtr’. R. Apaydm?, G. Cimgitt, K. Alpayt, 0. Cobanoglu ’ . ’ Facalty of h4edicke, Karadeniz i??cbrrica/ University, Trabzoa; Kocaeli, Twkey

‘Faculty

of Medicine,

Kocaeli

University,

We report two patients presenting many dome-shaped papules scattered on their cheeks, nose and eyelids. In both cases, Iaboratory investigations involving total blood count, biochemical profile, chest X-ray, and PPD test were found normal. In case 1, histopathological examination of skin biopsy revealed tuberculoid granulomas in dermis. In case 2, the skin biopsy showed the sarcoidal granulomas. We could not detect Mycobacterium