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Characterization of Carrier Individuals of Syndrome of Amelogenesis Imperfecta and Nephrocalcinosis
ORAL AND MAXILLOFACIAL PATHOLOGY e136 Abstracts thyroglossal duct cyst in a 75 year-old patient is presented. Although thyroglossal duct cyst is a benign cyst, we should consider that the risk of malign degeneration may increase with age. Keywords: A Giant thyroglossal duct cyst, old man
THE PROGNOSTIC EFFECTS OF P16 AND HPV EXPRESSIONS IN OROPHARENGEAL SQUAMOUS CELL CARCINOMAS Aysun Uguz1, Arbil Açıkalın1, Sevil Karabag1, Ülkü Tuncer2, Özgür Sürmelioglu2, 1Patoloji Bölümü, Çukurova Üniversitesi, Adana, Türkiye; 2KBB Bölümü, Çukurova Üniversitesi, Adana, Türkiye Objective: This study aims to prognostic significance of p16 and the relationship between p16 and HPV in patients with Oropharengeal Squamous Cell Carcinoma (OPSCC). Study Design: A total of 40 of OPSCC’s diagnosed during 5 years randomly selected and follow-up was obtained. Immunohistochemically(IHC) p16 and HPV was performed. Futures of tumor and HPV and p16 status was analyzed as statistically. Results: 77,5% of cases were localized in tongue. 9 patients were died due to tumor. HPV staining was weakly positive in 11 cases, p16 is positive in 22 cases. The median survival was 55.5 in patients. Statistically meaningful relation was detected between p16 positivity and median survival (p<0,02). Conclusions: p16 expession showed a better overall survival in OPSCC patients similar to the previous literature. However, we couldn’t find any relation between HPV and p16 expression. We suggest that IHC is a limited method for detect to HPV positivity and more sensitive procedure can be perform. Keywords: HPV, p16, Squamous Cell Carcinom
CHARACTERIZATION OF CARRIER INDIVIDUALS OF SYNDROME OF AMELOGENESIS IMPERFECTA AND NEPHROCALCINOSIS Anna Catharina Vieira Armond1, Maurício Da Rocha Dourado1, Cássio Roberto Rocha Dos Santos1, Ricardo Della Colleta2, Ana Terezinha Marques Mesquita1, 1Federal University of Jequitinhonha and Mucuri Valleys - UFVJM - Oral Pathology Laboratory/Dentistry Department- Diamantina, Brazil; 2State University of Campinas - UNICAMP - Molecular Biology Laboratory/ Oral Diagnosis Department- Piracicaba, Brazil Objective: Syndrome of amelogenesis imperfecta and nephrocalcinosis, is a rare autosomal recessive disorder caused by mutations in FAM20A gene. Is characterized by malformation of enamel, tooth eruption failure and renal calcifications. The study search to identify the main characteristics of the syndrome and establish diagnostic protocol. Study Design: Eleven patients from five family groups in Minas Gerais, Brazil, were evaluated. They were submitted to clinical and radiographic exam and renal ultrasonography. Results: The heredograms of families revealed consanguinity in most of cases. The clinical characteristics were amelogenesis imperfecta, microdontia, anodontia, prolonged retention of deciduous, malocclusion and gingival hyperplasia. Radiographs showed impacted permanent teeth with dental follicle hyperplasia, pulpal calcifications and absence of definition between radiopacity of enamel and dentin. Renal ultrasonography showed hyperechoic areas in the corticomedullary region. Conclusions: Patients diagnosed with amelogenesis imperfecta should be referred for nephrology research and the opposite is necessary for the possibility of coexistence of these changes.
OOOO March 2015 Keywords: Syndrome of amelogenesis imperfecta and nefrocalcinosis, Consanguinity, Pulpal calcification, Anodontia, Microdontia, Hyperechoic areas
PERIPHERAL DENTINOGENIC GHOST CELL TUMOUR: A CASE REPORT Firstine Kelsi Hartanto1, Lau Shin Hin2, 1 Department of Oral Maxillo-Facial Surgical and Mecical Sciences, Faculty Of Dentistry University Of Malaya, Kuala _ Lumpur, Malaysia; 2Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia Dentinogenic ghost cell tumour (DGCT) is a rare neoplasm. It accounts for about 1.9% to 2.1% of all odontogenic tumours. There are only a few cases of DGCT which have presented in extraosseous sites. A rare case of peripheral DGCT is reported in anterior maxillary gingiva of 62 year old female. The lesion presented as swelling with occasional bleeding and pain. The lesion was initially thought to be a pyogenic granuloma and was totally excised. Histopathological examination showed sheets of dentinoid material, ameloblastomatous islands with occasional ghost cell keratinization within fibrous connective tissue. It was finally diagnosed as a peripheral dentinogenic ghost cell tumour. Keywords: dentinogenic ghost cel tumour, dentinoid material, ameloblatomatous islands
SALIVARY GLAND TUMORS: A 14-YEAR RETROSPECTIVE STUDY IN A TAIWAN POPULATION Wen-Chen Wang1,2,3, Li-Min Lin1,2, Yuk-Kwan Chen1,2, Ching-Yi Chen1,2, Jer-Hao Kuo1, 1Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 2 Department of Oral Pathology and Diagnosis, Kaohsiung Medical University Hospital Kaohsiung, Taiwan; 3Department of Dentistry, Kaohsiung Municipal Ta-Tung Hospital,Kaohsiung, Taiwan Objective: The aim of this study was to evaluate the clinicopathological characteristics of salivary gland tumors (SGT) in the oral pathologic department of a medical center in Southern Taiwan. Study Design: A total of 135 cases of SGT (74 male and 61 female, mean age of 49.76) were retrospectively reviewed between 2000 and 2013. Results: There were 43 major salivary gland tumors with 5 malignancies in the series, 86 cases were benign (63.7%). The most common SGT was pleomorphic adenoma (61 cases, 45.19%), followed by mucoepidermoid carcinoma, adenoid cystic carcinomas and Warthin’s tumors. 46 cases located over palate (34.07%), 26.67% at parotid gland, and 11.11% at buccal mucosa. All the SGT over sublingual, intraosseous, mouth floor, gingival, edentulous ridge were malignant. Conclusions: The result emphasized the high malignant rate of oral SGT. All of tumor-like lesions of minor SG should be biopsied as soon as possible. Keywords: salivary gland disease, head and neck tumors, epidemiology, pathology
ROLE OF VEGF-FLT-1 SIGNALING IN ORAL CANCER PROGRESSION Ajiravudh Subarnbhesaj, Mutsumi Miyauchi, Chea Chanbora, Nurina Febriyanti Ayuningtyas, Phuong Thao Nguyen, Takashi Takata, Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University Objective: Vascular endothelial growth factor (VEGF)mediated angiogenesis plays a critical role in tumour growth and
THE PROGNOSTIC EFFECTS OF P16 AND HPV EXPRESSIONS IN OROPHARENGEAL SQUAMOUS CELL CARCINOMAS Aysun Uguz1, Arbil Açıkalın1, Sevil Karabag1, Ülkü Tuncer2, Özgür Sürmelioglu2, 1Patoloji Bölümü, Çukurova Üniversitesi, Adana, Türkiye; 2KBB Bölümü, Çukurova Üniversitesi, Adana, Türkiye Objective: This study aims to prognostic significance of p16 and the relationship between p16 and HPV in patients with Oropharengeal Squamous Cell Carcinoma (OPSCC). Study Design: A total of 40 of OPSCC’s diagnosed during 5 years randomly selected and follow-up was obtained. Immunohistochemically(IHC) p16 and HPV was performed. Futures of tumor and HPV and p16 status was analyzed as statistically. Results: 77,5% of cases were localized in tongue. 9 patients were died due to tumor. HPV staining was weakly positive in 11 cases, p16 is positive in 22 cases. The median survival was 55.5 in patients. Statistically meaningful relation was detected between p16 positivity and median survival (p<0,02). Conclusions: p16 expession showed a better overall survival in OPSCC patients similar to the previous literature. However, we couldn’t find any relation between HPV and p16 expression. We suggest that IHC is a limited method for detect to HPV positivity and more sensitive procedure can be perform. Keywords: HPV, p16, Squamous Cell Carcinom
CHARACTERIZATION OF CARRIER INDIVIDUALS OF SYNDROME OF AMELOGENESIS IMPERFECTA AND NEPHROCALCINOSIS Anna Catharina Vieira Armond1, Maurício Da Rocha Dourado1, Cássio Roberto Rocha Dos Santos1, Ricardo Della Colleta2, Ana Terezinha Marques Mesquita1, 1Federal University of Jequitinhonha and Mucuri Valleys - UFVJM - Oral Pathology Laboratory/Dentistry Department- Diamantina, Brazil; 2State University of Campinas - UNICAMP - Molecular Biology Laboratory/ Oral Diagnosis Department- Piracicaba, Brazil Objective: Syndrome of amelogenesis imperfecta and nephrocalcinosis, is a rare autosomal recessive disorder caused by mutations in FAM20A gene. Is characterized by malformation of enamel, tooth eruption failure and renal calcifications. The study search to identify the main characteristics of the syndrome and establish diagnostic protocol. Study Design: Eleven patients from five family groups in Minas Gerais, Brazil, were evaluated. They were submitted to clinical and radiographic exam and renal ultrasonography. Results: The heredograms of families revealed consanguinity in most of cases. The clinical characteristics were amelogenesis imperfecta, microdontia, anodontia, prolonged retention of deciduous, malocclusion and gingival hyperplasia. Radiographs showed impacted permanent teeth with dental follicle hyperplasia, pulpal calcifications and absence of definition between radiopacity of enamel and dentin. Renal ultrasonography showed hyperechoic areas in the corticomedullary region. Conclusions: Patients diagnosed with amelogenesis imperfecta should be referred for nephrology research and the opposite is necessary for the possibility of coexistence of these changes.
OOOO March 2015 Keywords: Syndrome of amelogenesis imperfecta and nefrocalcinosis, Consanguinity, Pulpal calcification, Anodontia, Microdontia, Hyperechoic areas
PERIPHERAL DENTINOGENIC GHOST CELL TUMOUR: A CASE REPORT Firstine Kelsi Hartanto1, Lau Shin Hin2, 1 Department of Oral Maxillo-Facial Surgical and Mecical Sciences, Faculty Of Dentistry University Of Malaya, Kuala _ Lumpur, Malaysia; 2Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia Dentinogenic ghost cell tumour (DGCT) is a rare neoplasm. It accounts for about 1.9% to 2.1% of all odontogenic tumours. There are only a few cases of DGCT which have presented in extraosseous sites. A rare case of peripheral DGCT is reported in anterior maxillary gingiva of 62 year old female. The lesion presented as swelling with occasional bleeding and pain. The lesion was initially thought to be a pyogenic granuloma and was totally excised. Histopathological examination showed sheets of dentinoid material, ameloblastomatous islands with occasional ghost cell keratinization within fibrous connective tissue. It was finally diagnosed as a peripheral dentinogenic ghost cell tumour. Keywords: dentinogenic ghost cel tumour, dentinoid material, ameloblatomatous islands
SALIVARY GLAND TUMORS: A 14-YEAR RETROSPECTIVE STUDY IN A TAIWAN POPULATION Wen-Chen Wang1,2,3, Li-Min Lin1,2, Yuk-Kwan Chen1,2, Ching-Yi Chen1,2, Jer-Hao Kuo1, 1Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 2 Department of Oral Pathology and Diagnosis, Kaohsiung Medical University Hospital Kaohsiung, Taiwan; 3Department of Dentistry, Kaohsiung Municipal Ta-Tung Hospital,Kaohsiung, Taiwan Objective: The aim of this study was to evaluate the clinicopathological characteristics of salivary gland tumors (SGT) in the oral pathologic department of a medical center in Southern Taiwan. Study Design: A total of 135 cases of SGT (74 male and 61 female, mean age of 49.76) were retrospectively reviewed between 2000 and 2013. Results: There were 43 major salivary gland tumors with 5 malignancies in the series, 86 cases were benign (63.7%). The most common SGT was pleomorphic adenoma (61 cases, 45.19%), followed by mucoepidermoid carcinoma, adenoid cystic carcinomas and Warthin’s tumors. 46 cases located over palate (34.07%), 26.67% at parotid gland, and 11.11% at buccal mucosa. All the SGT over sublingual, intraosseous, mouth floor, gingival, edentulous ridge were malignant. Conclusions: The result emphasized the high malignant rate of oral SGT. All of tumor-like lesions of minor SG should be biopsied as soon as possible. Keywords: salivary gland disease, head and neck tumors, epidemiology, pathology
ROLE OF VEGF-FLT-1 SIGNALING IN ORAL CANCER PROGRESSION Ajiravudh Subarnbhesaj, Mutsumi Miyauchi, Chea Chanbora, Nurina Febriyanti Ayuningtyas, Phuong Thao Nguyen, Takashi Takata, Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University Objective: Vascular endothelial growth factor (VEGF)mediated angiogenesis plays a critical role in tumour growth and