ROOK REVIEWS
Tune 1986
Chapter 1 by Webber introduces the subject of esophageal carcinoma and presents a superficial epidemiologic analysis. Curiously, one must read almost through the first page to infer (it is never specified!) that the author is referring to the squamous cell carcinoma, as opposed to adenocarcinoma, of the esophagus. Chapter 2 by BanksSchlegel and coworkers describes explant and monolayer cultures of normal human esophageal epithelium. Chapter 3 by Angorn and coauthors presents a number of cell lines derived from human esophageal carcinomas, and establishes a positive correlation between degree of in vivo malignancy and successful establishment of cell culture line in vitro. Chapter 4 by Nishihira et al. describes the properties of several cell lines derived from human esophageal carcinomas cultured in vitro and in vivo using nude mice. Chapter 5 by Stoner and coworkers deals with a culture of rat esophageal cells which, after in vitro transformation with carcinogens, result in tumors when transplanted in vivo to isogeneic animals. Chapter 6 by Rabin and colleagues describes a line derived from spontaneous esophageal carcinoma in rhesus monkeys from which type C retroviruses are isolated and characterized. Chapter 7 by Webber provides a schematic account of the epidemiology of colonic adenocarcinoma and explores some etiopathogenic possibilities that can be tested experimentally. Chapter 8 by Danes and Sutanto relates the isolation and establishment of human colonic epithelial cell cultures derived from normal mucosa and adenomatous polyps. Chapter 9 by Itzkowitz and coauthors reviews the development of human colonic cancer cell lines and analyzes their use in the eventual diagnosis and treatment of colonic cancer. Chapter 10 by Rutzky also surveys many human colonic cancer cell lines, but focuses on one such line capable of differentiating in vitro and of producing tumors in vivo when injected into nude mice. Chapter 11 by Moyer and coworkers deals with the successful culture of dog stomach, small bowel, and colon mucosal cell lines. Finally, chapter 12 by Marks et al. describes cell lines derived from mouse colon tumors, some of which metastasize while others do not. Because the editors seem to have given their contributors total freedom, it is impossible to formulate an opinion that will apply to the whole book. Heterogeneity is, perhaps, the quality that best characterizes this volume. For example, some of the articles present solid experimental work, if sometimes with fastidious focus on the minute technical aspects of their methodologies. Others, by contrast, present either weak or limited work. Yet others, like chapter 9 and to a certain extent chapter 10, present reasonably comprehensive accounts of work done in the field. Some chapters are well-referenced, sometimes lavishly, whereas others are rather scantily referenced. Finally, some works are well-illustrated whereas others are not. In summary, this volume is a collection of chapters with different authors, diverse approaches, and highly variable intrinsic quality, with a little to offer to every gastroenterologist, but precious little for any specialized researcher. jUAN LECHAGO, M.D.. Ph.D
Torrance, California
2037
Coloproctology: Diagnosis and Outpatient Management. By J. Nicholls and R. Glass. 236 pp.* $25.00. SpringerVerlag, New York, New York, 1985. Our understanding of the pathophysiology of the pelvic floor and anal sphincter mechanism has progressed rapidly over the past 5 to 10 years. This information has been presented predominantly at a research level and has largely eluded clinicians who are not directly in the field. For example, some are not aware that there are surgical options that might be offered to a patient who is incontinent. In addition, there have been fundamental changes in the management of common conditions such as hemorrhoids. CoJoproctoJogy is an opportune publication that outlines the outpatient management of patients with colorectal disease, incorporating these recent advances in a clear and concise manner. The authors initially consider examination and investigation of patients, placing the role of new techniques, such as anorectal manometry, in context. Diagnosis is then considered on the basis of the presenting symptom, utilizing excellent flow diagrams that clearly separate tedious detail from the text. Finally, each disease is described individually and new developments are highlighted. Any changes in management are debated when appropriate. Simple outpatient procedures are described in detail, such as rubber band ligation of hemorrhoids. Inpatient operative procedures have been excluded, expanding the audience for whom this book is suitable. If I have one criticism, it is that this book covers techniques utilized throughout the United Kingdom and Europe, and it does not give much space to techniques that are more popular with American colorectal surgeons. Above all, the book is concise and is easy to read. It achieves the authors’ aim of placing in context recent advances in colorectal disease. We would recommend this book to any clinician who encounters patients with disease of the large bowel. STANLEY M. GOLDBERG. M.D. IAN G. FINLAY, M.D.
Minneapolis,
Minnesota
Current Operative Surgery: General Surgery. Edited by A. Cuschieri and T. P. J. Hennessy. 148 pp., $27.50. Bailliere TindalliW. B. Saunders, Co., Philadelphia, Pennsylvania, 1985.
Innovative or controversial surgical therapies make for stimulating reading, and this volume of current operative surgery falls into this category. Eight of the nine chapters in this volume have a gastroenterological basis, covering variceal bleeding, ascites, gastric surgery, hepatic resection, morbid obesity, and spleen salvage. The single chapter on conservative and reconstructive surgery of the breast is strangely out of place in the context of the rest of the volume. The started aim of this volume is to present “newer operations” with a broad field of interest. This has been achieved and gives the reader, either surgeon or gastroenterologist, an appreciation of the trend toward more conservative, less ablative surgery.