CORRESPO~DENCE
441
References 1. Shute, E. V.: Canad . .M. A. J. 37: 350, 1937. 2. Idem: Vitamin "E" Symposium, London, England, April, 1930. 3. Rain, A.: Brit. M ..J. 2: 8, 1943. 4. Shute, E. V.: Ibid., Letter, November, 1943 . .5. Idem: J. Endoerinol. 2: 173, 1940. 6. Castrodal~,, D., Bierbaum, 0., Helwig, E. D., and Mac:Cryde, C'. M.: 363, 1941. 7. Tyslowitz, R., and Dingemanse, E.: Ibid. 29: 817, 1941.
Comment by Dr. Christy
Endocrinology 29:
To the Editor: I read with interest Dr. Shute's letter. The additional bibliography referring to my article is very informative but was not known to m, and the omission in my references was not intentional. My reasons and purpo:·e in undertaking this experimental study were stated in my artiele, and 1 had no previous knowledge or suggestions as to the physiologic role Vitamin E might play in menopause. As this study progresses I am more and more convinced tbat while its role in human metabolism remains somewhat obscure, Vitamin E has demonstrated its effectiveness in meno· pausal therapy, and its chief advantage over estrogens is in the fact that it is well tolerated and is fr.ee of any stimulative effect on the genital system, even after excessive doses are given. CHRIST J. CHRISTY, M.D. 663 N. OAK STREET, BUFFALO, N. Y. JANUARY 24, 1946.